公开(公告)号：US20240197654A1

公开(公告)日：2024-06-20

申请号：US18594233

申请日：2024-03-04

Applicant: Duke University

Inventor： Suzanne E. Wardell ,  Erik R. Nelson ,  Donald P. McDonnell

IPC: A61K31/137 ,  A61K9/00 ,  A61K31/136 ,  A61K31/138 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/5685 ,  A61K45/06 ,  A61P35/00 ,  C07C217/78 ,  C07C217/84

CPC classification number: A61K31/137 ,  A61K9/0019 ,  A61K31/136 ,  A61K31/138 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/5685 ,  A61K45/06 ,  C07C217/78 ,  C07C217/84 ,  A61K2121/00 ,  A61P35/00

Abstract: Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a SERM.

公开(公告)号：US08399520B2

公开(公告)日：2013-03-19

申请号：US13048391

申请日：2011-03-15

Applicant: Shinichi Hamaoka ,  Noritaka Kitazawa ,  Kazumasa Nara ,  Atsushi Sasaki ,  Atsushi Kamada ,  Tadashi Okabe

Inventor： Shinichi Hamaoka ,  Noritaka Kitazawa ,  Kazumasa Nara ,  Atsushi Sasaki ,  Atsushi Kamada ,  Tadashi Okabe

IPC: A61K31/137 ,  C07C217/84

CPC classification number: C07C217/22 ,  C07C215/78 ,  C07C217/18 ,  C07C217/78 ,  C07C217/84 ,  C07C219/34 ,  C07C323/25 ,  C07C2602/10 ,  C07D205/04 ,  C07D207/09 ,  C07D209/08 ,  C07D209/14 ,  C07D209/30 ,  C07D209/44 ,  C07D211/14 ,  C07D211/26 ,  C07D211/46 ,  C07D211/58 ,  C07D213/38 ,  C07D213/64 ,  C07D213/73 ,  C07D223/16 ,  C07D243/08 ,  C07D277/66 ,  C07D295/088 ,  C07D295/13 ,  C07D295/135 ,  C07D307/14 ,  C07D309/04 ,  C07D309/14 ,  C07D311/58 ,  C07D317/66 ,  C07D333/20 ,  C07D333/58 ,  C07D405/12 ,  C07D451/06 ,  C07D453/02 ,  C07D487/08 ,  C07D491/10 ,  C07F5/025 ,  C07F7/1804 ,  C07F7/2208

Abstract: The present invention provides a compound represented by the following formula (I); [wherein T represents a single bond, a C1-C4 alkylene group which may have a substituent and the like; formula (I-1) represents a single bond or a double bond; A represents a single bond, a bivalent 5- to 14-membered heterocyclic group which may have a substituent and the like; Y represents a single bond and the like; Z represents a methylene group and the like; ring G represents a phenylene group and the like which may condense with a 5- to 6-membered ring and may have a heteroatom; Ra and Rb are the same as or different from each other and represent a hydrogen atom and the like; W represents a single bond and the like; R′ represents 1 to 4 independent hydrogen atoms and the like; and R″ represents 1 to 4 independent hydrogen atoms and the like] or a salt thereof, or a hydrate thereof.

Abstract translation: 本发明提供由下式（I）表示的化合物。 [其中T表示单键，可以具有取代基的C1-C4亚烷基等; 式（I-1）表示单键或双键; A表示单键，可以具有取代基的二价5〜14元杂环基等; Y表示单键等; Z表示亚甲基等; 环G表示可以用5-至6-元环缩合并可具有杂原子的亚苯基等; R a和R b彼此相同或不同，表示氢原子等; W表示单键等; R'表示1〜4个独立的氢原子等; R“表示1〜4个独立的氢原子等]或其盐或其水合物。

公开(公告)号：US20160324808A1

公开(公告)日：2016-11-10

申请号：US15214187

申请日：2016-07-19

Applicant: Duke University

Inventor： Suzanne E. Wardell ,  Erik R. Nelson ,  Donald P. McDonnell

IPC: A61K31/137 ,  A61K9/00 ,  A61K45/06

CPC classification number: A61K31/4535 ,  A61K9/0019 ,  A61K31/136 ,  A61K31/137 ,  A61K31/138 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/565 ,  A61K31/5685 ,  A61K45/06 ,  A61K2121/00 ,  C07C217/78 ,  C07C217/84 ,  A61K2300/00

Abstract: Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a SERM.

公开(公告)号：US08361638B2

公开(公告)日：2013-01-29

申请号：US12936644

申请日：2009-03-11

Applicant: Philipp Stoessel ,  Holger Heil ,  Dominik Joosten ,  Christof Pflumm ,  Anja Gerhard

Inventor： Philipp Stoessel ,  Holger Heil ,  Dominik Joosten ,  Christof Pflumm ,  Anja Gerhard

IPC: H01L51/54

CPC classification number: C07D209/86 ,  C07C13/567 ,  C07C13/58 ,  C07C25/22 ,  C07C49/792 ,  C07C49/84 ,  C07C205/06 ,  C07C211/54 ,  C07C211/58 ,  C07C211/61 ,  C07C217/78 ,  C07C217/92 ,  C07C225/22 ,  C07C255/51 ,  C07C255/56 ,  C07C255/58 ,  C07C317/14 ,  C07C321/28 ,  C07C321/30 ,  C07C2603/18 ,  C07C2603/24 ,  C07C2603/42 ,  C07C2603/52 ,  C07D235/08 ,  C07D251/24 ,  C07D471/14 ,  C07F5/02 ,  C07F5/025 ,  C07F7/0805 ,  C07F9/5027 ,  C07F9/5329 ,  C09B1/00 ,  C09B3/02 ,  C09B3/12 ,  C09B15/00 ,  C09B17/00 ,  C09B19/00 ,  C09B57/00 ,  C09B57/007 ,  C09B57/008 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1029 ,  C09K2211/1033 ,  C09K2211/1037 ,  C09K2211/1044 ,  C09K2211/1059 ,  C09K2211/1088 ,  C09K2211/1092 ,  H01L51/0058 ,  H01L51/0059 ,  H01L51/006 ,  H01L51/0072 ,  H01L51/5048 ,  H01L51/5096 ,  H05B33/14 ,  Y02E10/549

Abstract: The present invention relates to fluorine derivatives and organic electronic devices in which said compounds are used as a matrix material in the emitting layer and/or as a hole transport material, and/or as an electron blocking or exciton blocking material, and/or as an electron transport material.

Abstract translation: 本发明涉及氟衍生物和有机电子器件，其中所述化合物用作发光层和/或空穴传输材料中的基质材料，和/或作为电子阻挡或激子阻挡材料，和/或 电子传输材料。

公开(公告)号：US20060116364A1

公开(公告)日：2006-06-01

申请号：US11158245

申请日：2005-06-22

Applicant: Shinichi Hamaoka ,  Noritaka Kitazawa ,  Kazumasa Nara ,  Atsushi Sasaki ,  Atsushi Kamada ,  Tadashi Okabe

Inventor： Shinichi Hamaoka ,  Noritaka Kitazawa ,  Kazumasa Nara ,  Atsushi Sasaki ,  Atsushi Kamada ,  Tadashi Okabe

IPC: A61K31/55 ,  A61K31/4439 ,  A61K31/428 ,  A61K31/405 ,  A61K31/4025 ,  C07D417/02 ,  C07D43/02

CPC classification number: C07C217/22 ,  C07C215/78 ,  C07C217/18 ,  C07C217/78 ,  C07C217/84 ,  C07C219/34 ,  C07C323/25 ,  C07C2602/10 ,  C07D205/04 ,  C07D207/09 ,  C07D209/08 ,  C07D209/14 ,  C07D209/30 ,  C07D209/44 ,  C07D211/14 ,  C07D211/26 ,  C07D211/46 ,  C07D211/58 ,  C07D213/38 ,  C07D213/64 ,  C07D213/73 ,  C07D223/16 ,  C07D243/08 ,  C07D277/66 ,  C07D295/088 ,  C07D295/13 ,  C07D295/135 ,  C07D307/14 ,  C07D309/04 ,  C07D309/14 ,  C07D311/58 ,  C07D317/66 ,  C07D333/20 ,  C07D333/58 ,  C07D405/12 ,  C07D451/06 ,  C07D453/02 ,  C07D487/08 ,  C07D491/10 ,  C07F5/025 ,  C07F7/1804 ,  C07F7/2208

Abstract: The present invention provides a compound represented by the following formula [wherein T represents a single bond, a C1-C4 alkylene group which may have a substituent and the like; formula (I-1) represents a single bond or a double bond; A represents a single bond, a bivalent 5- to 14-membered heterocyclic group which may have a substituent and the like; Y represents a single bond and the like; Z represents a methylene group and the like; ring G represents a phenylene group and the like which may condense with a 5- to 6-membered ring and may have a heteroatom; Ra and Rb are the same as or different from each other and represent a hydrogen atom and the like; W represents a single bond and the like; R′ represents 1 to 4 independent hydrogen atoms and the like; and R″ represents 1 to 4 independent hydrogen atoms and the like] or a salt thereof, or a hydrate thereof

Abstract translation: 本发明提供由下式表示的化合物[其中T表示单键，可具有取代基的C 1 -C 4亚烷基等; 式（I-1）表示单键或双键; A表示单键，可以具有取代基的二价5〜14元杂环基等; Y表示单键等; Z表示亚甲基等; 环G表示可以用5-至6-元环缩合并可具有杂原子的亚苯基等; R a和R b彼此相同或不同，表示氢原子等; W代表单键等; R'表示1〜4个独立的氢原子等; R“表示1〜4个独立的氢原子等]或其盐或其水合物

公开(公告)号：US20240349587A1

公开(公告)日：2024-10-17

申请号：US18134751

申请日：2023-04-14

Applicant: Kaunas University of Technology

Inventor： Vytautas Getautis ,  Maryte Daskeviciene ,  Sarune Daskeviciute-Geguziene ,  Kasparas Rakstys ,  Atsushi Wakamiya ,  Minh Anh Truong

IPC: H10K85/10 ,  C07C217/78 ,  C07D209/88 ,  C08G61/12 ,  H01G9/00 ,  H01G9/20 ,  H10K30/86 ,  H10K50/15 ,  H10K71/12

CPC classification number: H10K85/115 ,  C07C217/78 ,  C07D209/88 ,  C08G61/12 ,  H01G9/0029 ,  H01G9/20 ,  H10K30/86 ,  H10K50/15 ,  H10K71/12 ,  C07C2603/97 ,  C08G2261/11 ,  C08G2261/1424 ,  C08G2261/1434 ,  C08G2261/148 ,  C08G2261/18 ,  C08G2261/226 ,  C08G2261/228 ,  C08G2261/312 ,  C08G2261/3142 ,  C08G2261/3162 ,  C08G2261/354 ,  C08G2261/364 ,  C08G2261/512 ,  C08G2261/91 ,  C08G2261/94 ,  H10K30/40 ,  H10K30/50

Abstract: The 9,9′-spirobifluorene-based compounds and mixtures including 9,9′-spirobifluorene compounds with crosslinkable functional groups and compounds with two or more thiol groups, can stabilize one or more underlying layers of the hole transporting layer and/or interlayer during liquid fabrication process of optoelectronic and/or photoelectrochemical devices. More particularly, the compounds are hole transport materials that include crosslinkable functional groups covalently bonded to 9,9′-spirobifluorene hole transporting structure and mixtures including hole transporting crosslinkable 9,9′-spirobifluorene and thiol derivatives, which may crosslink, such as by exposure to UV, visible light, and/or heat. Photovoltaic devices may employ these compounds and mixtures in crosslinked forms.

公开(公告)号：US20230422604A1

公开(公告)日：2023-12-28

申请号：US18035554

申请日：2021-12-17

Applicant: LG Chem, Ltd.

Inventor： Minseob Seo ,  Dongwhan Lee ,  Youngju Park ,  Doowhan Choi ,  Seung Jun Yoo ,  Jaesoon Bae ,  Jaechol Lee

IPC: H10K85/60 ,  C07C217/78 ,  C09K11/06 ,  C07C211/61

CPC classification number: H10K85/633 ,  C07C217/78 ,  C09K11/06 ,  C07C211/61 ,  H10K50/17

Abstract: The present disclosure relates to a compound represented by Chemical Formula 1, a coating composition including the compound represented by Chemical Formula 1, an organic light emitting device using the same, and a method for manufacturing the same:






wherein L1 to L5, R1 to R4, Af1, Af2, Ar1, X1, X2, r1 to r4, m1 to m6, f1 and f2 are described herein.

公开(公告)号：US07960412B2

公开(公告)日：2011-06-14

申请号：US12544965

申请日：2009-08-20

Applicant: Shinichi Hamaoka ,  Noritaka Kitazawa ,  Kazumasa Nara ,  Atsushi Sasaki ,  Atsushi Kamada ,  Tadashi Okabe

Inventor： Shinichi Hamaoka ,  Noritaka Kitazawa ,  Kazumasa Nara ,  Atsushi Sasaki ,  Atsushi Kamada ,  Tadashi Okabe

IPC: A61K31/445 ,  C07D211/06

CPC classification number: C07C217/22 ,  C07C215/78 ,  C07C217/18 ,  C07C217/78 ,  C07C217/84 ,  C07C219/34 ,  C07C323/25 ,  C07C2602/10 ,  C07D205/04 ,  C07D207/09 ,  C07D209/08 ,  C07D209/14 ,  C07D209/30 ,  C07D209/44 ,  C07D211/14 ,  C07D211/26 ,  C07D211/46 ,  C07D211/58 ,  C07D213/38 ,  C07D213/64 ,  C07D213/73 ,  C07D223/16 ,  C07D243/08 ,  C07D277/66 ,  C07D295/088 ,  C07D295/13 ,  C07D295/135 ,  C07D307/14 ,  C07D309/04 ,  C07D309/14 ,  C07D311/58 ,  C07D317/66 ,  C07D333/20 ,  C07D333/58 ,  C07D405/12 ,  C07D451/06 ,  C07D453/02 ,  C07D487/08 ,  C07D491/10 ,  C07F5/025 ,  C07F7/1804 ,  C07F7/2208

Abstract: The present invention provides a compound represented by the following formula (I); [wherein T represents a single bond, a C1-C4 alkylene group which may have a substituent and the like;   (I-1) formula (I-1) represents a single bond or a double bond; A represents a single bond, a bivalent 5- to 14-membered heterocyclic group which may have a substituent and the like; Y represents a single bond and the like; Z represents a methylene group and the like; ring G represents a phenylene group and the like which may condense with a 5- to 6-membered ring and may have a heteroatom; Ra and Rb are the same as or different from each other and represent a hydrogen atom and the like; W represents a single bond and the like; R′ represents 1 to 4 independent hydrogen atoms and the like; and R″ represents 1 to 4 independent hydrogen atoms and the like] or a salt thereof, or a hydrate thereof.

Abstract translation: 本发明提供由下式（I）表示的化合物。 [其中T表示单键，可以具有取代基的C1-C4亚烷基等; （I-1）式（I-1）表示单键或双键; A表示单键，可以具有取代基的二价5〜14元杂环基等; Y表示单键等; Z表示亚甲基等; 环G表示可以用5-至6-元环缩合并可具有杂原子的亚苯基等; R a和R b彼此相同或不同，表示氢原子等; W表示单键等; R'表示1〜4个独立的氢原子等; R“表示1〜4个独立的氢原子等]或其盐或其水合物。

公开(公告)号：US20100108997A1

公开(公告)日：2010-05-06

申请号：US12587793

申请日：2009-10-13

Applicant: Young Gil Kim ,  Young Jun Cho ,  Chi Sik Kim ,  Sung Jin Eum ,  Hyuck Joo Kwon ,  Bong Ok Kim ,  Sung Min Kim ,  Seung Soo Yoon

Inventor： Young Gil Kim ,  Young Jun Cho ,  Chi Sik Kim ,  Sung Jin Eum ,  Hyuck Joo Kwon ,  Bong Ok Kim ,  Sung Min Kim ,  Seung Soo Yoon

IPC: H01L51/54 ,  C07C211/43

CPC classification number: C09K11/06 ,  C07C211/54 ,  C07C211/58 ,  C07C211/61 ,  C07C217/78 ,  C07C217/92 ,  C07C255/58 ,  C07C323/38 ,  C07C2603/16 ,  C07C2603/18 ,  C07C2603/20 ,  C07C2603/26 ,  C07C2603/40 ,  C07C2603/42 ,  C07C2603/52 ,  C07C2603/94 ,  C07D209/86 ,  C07D213/38 ,  C07D215/06 ,  C07D215/38 ,  C07D217/22 ,  C07D219/02 ,  C07D251/22 ,  C07D265/38 ,  C07D279/22 ,  C07D333/20 ,  C07D401/12 ,  C07F7/081 ,  C07F7/0816 ,  C09K2211/1011 ,  C09K2211/1014 ,  H01L51/0054 ,  H01L51/006 ,  H01L51/5012 ,  H05B33/14 ,  Y02E10/549

Abstract: Provided are novel organic electroluminescent compounds, and organic electroluminescent devices comprising the same as electroluminescent material. Specifically, the organic electroluminescent compounds according to the present invention are represented by Chemical Formula (1): wherein, at least one substituent(s) among Ar1, Ar2, R6, R7, R8, R9, R10, R11, R12, R13, R14 and R15 represent(s) The organic electroluminescent compounds according to the present invention exhibit high luminous efficiency and excellent life property of material, so that an OLED having very good operation life can be manufactured therefrom. Further, the organic electroluminescent compound according to the present invention, when it is contained in an electroluminescent layer or a hole transport layer, lowers the operation voltage to result in noticeable decrease in power consumption, with exhibiting at least comparable luminous efficiency as compared to conventional OLED's.

Abstract translation: 提供了新颖的有机电致发光化合物和包含与电致发光材料相同的有机电致发光器件。 具体地说，本发明的有机电致发光化合物由化学式（1）表示：其中Ar 1，Ar 2，R 6，R 7，R 8，R 9，R 10，R 11，R 12，R 13， R14和R15表示本发明的有机电致发光化合物具有高的发光效率和优异的材料寿命，从而可以制造具有非常好的使用寿命的OLED。 此外，根据本发明的有机电致发光化合物当其被包含在电致发光层或空穴传输层中时，降低了操作电压，导致功率消耗的显着降低，与传统的相比，具有至少相当的发光效率 OLED的。

公开(公告)号：US20230398085A1

公开(公告)日：2023-12-14

申请号：US18457567

申请日：2023-08-29

Applicant: Duke University

Inventor： Suzanne E. Wardell ,  Erik R. Nelson ,  Donald P. McDonnell

IPC: A61K31/137 ,  A61K9/00 ,  A61K31/136 ,  A61K31/138 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/5685 ,  A61K45/06 ,  C07C217/78 ,  C07C217/84

CPC classification number: A61K31/137 ,  A61K9/0019 ,  A61K31/136 ,  A61K31/138 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/5685 ,  A61K45/06 ,  C07C217/78 ,  C07C217/84 ,  A61K2121/00

Abstract: Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a SERM.