公开(公告)号：US12059477B2

公开(公告)日：2024-08-13

申请号：US17579115

申请日：2022-01-19

申请人： Beam Therapeutics Inc.

发明人： Cory Dane Sago ,  Gregory Lawrence Hamilton

IPC分类号： A61K47/69 ,  A61K31/7105 ,  A61K31/711 ,  A61K47/24 ,  A61K47/26 ,  A61P1/16 ,  C07C219/06 ,  C07D295/13

CPC分类号： A61K47/6929 ,  A61K31/7105 ,  A61K31/711 ,  A61K47/24 ,  A61K47/26 ,  A61P1/16 ,  C07C219/06 ,  C07D295/13

摘要： The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.

公开(公告)号：US20240190808A1

公开(公告)日：2024-06-13

申请号：US18501945

申请日：2023-11-03

申请人： Orna Therapeutics, Inc.

发明人： Allen T. HORHOTA ,  Junghoon YANG ,  Kevin J. KAUFFMAN ,  Thomas BARNES ,  Robert Alexander WESSELHOEFT ,  Amy M. BECKER ,  Gregory MOTZ

IPC分类号： C07C219/06 ,  A61K31/7105 ,  A61K47/54

CPC分类号： C07C219/06 ,  A61K31/7105 ,  A61K47/543

摘要： Disclosed herein are novel lipids that can be used in combination with other lipid components, such as helper lipids, structural lipids, and cholesterols, to form lipid nanoparticles for delivery of therapeutic agents, such as nucleic acids (e.g., circular polynucleotides), both in vitro and in vivo.

公开(公告)号：US20230348359A1

公开(公告)日：2023-11-02

申请号：US18220874

申请日：2023-07-12

申请人： Beam Therapeutics Inc.

发明人： Mina Fawzy Shehata ,  Gregory Lawrence Hamilton ,  Neeraj Narendra Patwardhan ,  Cory Dane Sago ,  Milloni Balwantkumar Chhabra

IPC分类号： A61K9/51 ,  C07J41/00 ,  C07C219/06 ,  A61K48/00

CPC分类号： C07C219/06 ,  A61K9/5123 ,  A61K48/0033 ,  C07J41/0088 ,  C07C2601/14 ,  C07C2603/74

摘要： The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.

公开(公告)号：US11739053B2

公开(公告)日：2023-08-29

申请号：US16365532

申请日：2019-03-26

申请人： ID4PHARMA, LLC

发明人： Xiang-Qun Xie ,  Garson David Roodman ,  Kyaw-Zeyar Myint ,  Noriyoshi Kurihara

IPC分类号： C07C229/36 ,  C07D309/40 ,  C07C211/50 ,  C07C317/34 ,  C07C217/58 ,  C07C217/76 ,  C07C219/06 ,  C07D241/44 ,  C07C229/14 ,  C07D487/04 ,  C07C235/48 ,  C07C251/76 ,  A61K31/137 ,  A61K31/351 ,  A61K31/495 ,  A61K31/519 ,  A61K31/15 ,  A61K31/498 ,  A61K45/06 ,  C07C249/16 ,  C07D309/32 ,  C07D475/08 ,  C12N5/09 ,  A61K31/216

CPC分类号： C07C229/36 ,  A61K31/137 ,  A61K31/15 ,  A61K31/216 ,  A61K31/351 ,  A61K31/495 ,  A61K31/498 ,  A61K31/519 ,  A61K45/06 ,  C07C211/50 ,  C07C217/58 ,  C07C217/76 ,  C07C219/06 ,  C07C229/14 ,  C07C235/48 ,  C07C249/16 ,  C07C251/76 ,  C07C317/34 ,  C07D241/44 ,  C07D309/32 ,  C07D309/40 ,  C07D475/08 ,  C07D487/04 ,  C12N5/0693

摘要： A method for treating a p62-mediated disease (e.g., multiple myeloma) in a subject, the method comprising administering to the subject a therapeutically effective amount of at least one p62-ZZ inhibitor compound.

公开(公告)号：US20230233468A1

公开(公告)日：2023-07-27

申请号：US18163117

申请日：2023-02-01

申请人： SUZHOU ABOGEN BIOSCIENCES CO., LTD.

发明人： Bo YING ,  Xiulian WANG

IPC分类号： A61K9/16 ,  C07C217/28 ,  C07C219/06 ,  C07D295/13 ,  C07C229/22 ,  C07C229/16 ,  C07C235/06 ,  C07D207/24

CPC分类号： A61K9/1617 ,  C07C217/28 ,  C07C219/06 ,  C07D295/13 ,  C07C229/22 ,  C07C229/16 ,  C07C235/06 ,  C07D207/24 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18

摘要： Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipid compounds.

公开(公告)号：US20230202966A1

公开(公告)日：2023-06-29

申请号：US17972395

申请日：2022-10-24

申请人： Renagade Therapeutics Management Inc.

发明人： Muthusamy Jayaraman ,  Stephen Scully

IPC分类号： C07C219/06 ,  C07C219/08 ,  C07C219/10

CPC分类号： C07C219/06 ,  C07C219/08 ,  C07C219/10

摘要： The present disclosure details various lipids, compositions, and/or methods of optimized systems and delivery vehicles for the delivery of nucleic acid sequences, polypeptides or peptides for use in vaccinating against infectious agents.

公开(公告)号：US11648324B2

公开(公告)日：2023-05-16

申请号：US17317517

申请日：2021-05-11

申请人： Acuitas Therapeutics, Inc.

发明人： Steven M. Ansell ,  Xinyao Du

IPC分类号： A61K48/00 ,  A61K9/127 ,  C07C219/06 ,  C07C229/16 ,  C07C233/18 ,  C07C255/24 ,  C12N9/02 ,  A61K47/18 ,  C07C229/12

CPC分类号： A61K48/0033 ,  A61K9/127 ,  A61K47/18 ,  C07C219/06 ,  C07C229/12 ,  C07C229/16 ,  C07C233/18 ,  C07C255/24 ,  C12N9/0069 ,  C12Y113/12007

摘要： Compounds are provided having the following structure:




or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

公开(公告)号：US11639329B2

公开(公告)日：2023-05-02

申请号：US16638733

申请日：2018-08-16

申请人： ACUITAS THERAPEUTICS, INC.

发明人： Xinyao Du

IPC分类号： C07C229/16 ,  C07C219/06 ,  A61K47/54 ,  A61K47/69 ,  A61K47/60 ,  A61K9/51 ,  C12N15/113 ,  A61K31/23

摘要： Compounds are provided having the following structure: [Formula should be inserted here] or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

公开(公告)号：US20230111600A1

公开(公告)日：2023-04-13

申请号：US17786081

申请日：2020-12-15

申请人： MOMENTIVE PERFORMANCE MATERIALS GMBH

发明人： Roland WAGNER ,  Katharina STREICHER ,  Laura ROHMANN ,  Christian WENSKE ,  Shrutisagar Dattatraya HAVELI

IPC分类号： A61K8/41 ,  A61Q5/12 ,  A61Q19/00 ,  C07C219/06 ,  A61Q5/02 ,  A61Q5/06

摘要： The present invention is directed at mono-, di- or polyquaternary ammonium compounds of the formula (I) wherein x is 1 to 50, and F can be the same or different and is represented by the general formula (II) wherein at least one of the optionally substituted and optionally functional-group-containing hydrocarbon radicals R1, R2, R3, R4 or R5 contains at least one estolide moiety comprising two or more ester or amide moieties. The invention also relates to a process for the synthesis of such compounds, the use of the compounds in cosmetic formulations for skin and hair care, cosmetic compositions for the treatment of fibers, and compositions containing one or more of the compounds for the treatment of hair.

公开(公告)号：US20220072155A1

公开(公告)日：2022-03-10

申请号：US17317517

申请日：2021-05-11

申请人： Acuitas Therapeutics, Inc.

发明人： Steven M. Ansell ,  Xinyao Du

IPC分类号： A61K48/00 ,  A61K9/127 ,  C07C219/06 ,  C07C229/16 ,  C07C233/18 ,  C07C255/24 ,  C12N9/02 ,  A61K47/18 ,  C07C229/12

摘要： Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.