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1.发明公开公开(公告)号：US20240344020A1
公开(公告)日：2024-10-17
申请号：US18577457
申请日：2021-07-28
发明人： Qingsong LIU , Jie HU , Tao HUANG , Cheng CHEN
CPC分类号： C12N5/0018 , C12N5/0693 , C12N2501/105 , C12N2501/117 , C12N2501/12 , C12N2501/2306 , C12N2501/999 , C12N2503/02
摘要： A primary cell culture medium for culturing primary lung cancer epithelial cells, containing an MST1/2 kinase inhibitor, a ROCK inhibitor, fibroblast growth factor 7, at least one additive of B27 additive and N2 additive, hepatocyte growth factor, insulin-like growth factor 1, interleukin 6, and a TGFβ type I receptor inhibitor. The invention also relates to a culture method using the primary cell culture medium and its application in the efficacy evaluating and screening of drugs. In the culture method, the primary cell culture medium is used to culture primary cells in a culture vessel coated with an extracellular matrix gel, to make the primary cells expend rapidly. A cell model obtained using the primary cell culture medium and the primary cell culture method can be used for the efficacy evaluating and screening of drugs.
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公开(公告)号：US20240344005A1
公开(公告)日：2024-10-17
申请号：US18631480
申请日：2024-04-10
申请人： EMULATE, Inc.
发明人： Geraldine A. Hamilton , Norman Wen , Catherine Karalis , Antonio Varone , Daniel Levner , Riccardo Barrile
CPC分类号： C12M23/16 , C12M25/02 , C12N5/0693 , G01N33/5011 , G01N33/5017
摘要： The invention generally relates to a microfluidic platforms or “chips” for testing and understanding cancer, and, more specifically, for understanding the factors that contribute to cancer invading tissues and causing metastases. Tumor cells are grown on microfluidic devices with other non-cancerous tissues under conditions that simulate tumor invasion. The interaction with immune cells can be tested to inhibit this activity by linking a cancer chip to a lymph chip.
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公开(公告)号：US20240319170A1
公开(公告)日：2024-09-26
申请号：US18275125
申请日：2021-02-05
发明人： Qingsong LIU , Yuying HE , Cheng CHEN , Tao HUANG , Tao REN , Wenchao WANG , Li WANG
CPC分类号： G01N33/5011 , C12N5/0693 , C12N2500/02 , C12N2501/01 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/12 , C12N2501/2322 , C12N2509/00
摘要： Disclosed are a culture medium and a culture method for in vitro expansion of primary cells of intestinal cancer. The culture medium comprises an initial culture medium, a Rho protease inhibitor, an antibiotic, gastrin, A8301, a non-essential amino acid, cholera toxin, an insulin-like growth factor-1, nicotinamide, insulin, fetal bovine serum, and an additive selected from at least one of a B27 additive and an N2 additive. By using the culture medium, effective and rapid expansion of the primary cells of intestinal cancer can be achieved. The expanded cells maintain the pathological characteristics of patients, and the culture success rate and the cell expansion rate of the primary cells of intestinal cancer are improved, which provide a research foundation for personalized treatment of the patients.
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公开(公告)号：US12083355B1
公开(公告)日：2024-09-10
申请号：US18400131
申请日：2023-12-29
发明人： Meihua Chen , Pingjin Zou , Xinyu Xue , Jinyi Lang , Lili Xing , Rui Lin
CPC分类号： A61N5/062 , A61K41/0071 , C12N5/0693 , C12N13/00 , G01N33/5091 , H05B45/30 , A61N2005/0652
摘要： A photodynamic therapy tablet and corresponding preparation method, as well as a construction method and system specifically designed for anti-tumor models, are disclosed. The tablet includes a wireless power supply unit, a circuit unit, micrometer-level LED array, and a flexible transparent biocompatible encapsulation. It can be surgically implanted in close proximity to tumor cells within the human body, enabling precise irradiation of the targeted tumor cells. By harnessing light of a specific wavelength, the tablet facilitates the generation of lipid peroxides, which, in conjunction with a ferroptosis inducer, effectively triggers ferroptotic cell death in tumor cells. The ultrasound wireless self-powering photodynamic therapy tablet is utilized for the treatment of tumor cells through photodynamic therapy (PDT). By combining the ferroptosis inducer with PDT, the present invention effectively addresses the issue of limited efficacy observed when using the ferroptosis inducer alone.
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公开(公告)号：US20240290421A1
公开(公告)日：2024-08-29
申请号：US18206981
申请日：2023-06-07
CPC分类号： G16B20/00 , C12N5/0693 , C12N5/0694 , C12N9/22 , C12N15/1058 , C12N15/1089 , C12N15/1096 , C12N15/11 , C12N15/86 , G06N20/00 , G16B40/20 , C12N2310/20 , C12N2740/15043 , C12N2800/80
摘要： The present disclosure provides methods and systems for identification of genomic regions for therapeutic targeting. A method for identifying one or more genomic regions for therapeutic targeting, which may facilitate re-programming of a cell from one phenotypic state to another, may comprise: providing single-cell RNA-seq data for a plurality of diseased cells and a plurality of normal cells of a cell type; mapping the single-cell RNA-seq data for the plurality of diseased cells and the plurality of normal cells into a latent space corresponding to a plurality of phenotypic states of the cell type; identifying, based at least in part on a topology of the latent space, the one or more genomic regions for therapeutic targeting; and electronically outputting the one or more genomic regions for therapeutic targeting.
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公开(公告)号：US12070747B2
公开(公告)日：2024-08-27
申请号：US17554369
申请日：2021-12-17
申请人： NEW YORK UNIVERSITY
CPC分类号： B01L3/5027 , C12M23/16 , C12N5/0693 , B01L2200/0647
摘要： The present invention provides a discrete microenvironment chamber (DIMIC) configured to accurately mimics the microenvironment of poorly perfused tissue. In one embodiment, the DIMIC of the present invention is further designed to allow the extraction of cells and media from different local environments for any type of biochemical analysis.
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公开(公告)号：US20240279617A1
公开(公告)日：2024-08-22
申请号：US18566519
申请日：2022-06-06
发明人： Deok-Ho Kim , Chia-Yi Su , Alice Burchett , Marcus Williams
CPC分类号： C12N5/0693 , C12M27/14 , G01N33/5011 , C12N2503/02 , C12N2533/54
摘要： Assay and systems are provided that include use of cells and/or organoid for patient diagnosis, drug development, and personalized medicine, including for diagnosis and treatment of cancer and associated diseases and disorders. In one aspect, systems and methods include applying a phase-specific and force-guided polymerization of a biomaterial, wherein the polymerization comprises a nucleation phase and an elongation phase; thereby, producing a model.
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公开(公告)号：US20240279597A1
公开(公告)日：2024-08-22
申请号：US18603745
申请日：2024-03-13
发明人： Taito NISHINO , Tatsuro KANAKI , Ayako OTANI , Koichiro SARUHASHI , Misayo TOMURA , Takehisa IWAMA , Masato HORIKAWA , Norio NAKATSUJI , Tomomi OTSUJI
CPC分类号： C12N5/0043 , C12N5/005 , C12N5/067 , C12N5/0693 , G01N33/5011 , G01N33/5014 , G01N33/5044 , G01N33/5067 , C12N2500/14 , C12N2500/34 , C12N2531/00 , C12N2533/80
摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like
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公开(公告)号：US20240279354A1
公开(公告)日：2024-08-22
申请号：US18626607
申请日：2024-04-04
CPC分类号： C07K16/30 , A61P35/00 , C07K14/00 , C07K16/2809 , C12N5/0693 , A61K38/00 , A61K2039/505 , A61K2039/54 , A61K2039/545 , A61K2039/572 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/60 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/01 , C07K2319/035 , C07K2319/21 , C07K2319/30 , C07K2319/31 , C07K2319/50 , C12N2523/00
摘要： The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.
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公开(公告)号：US20240277770A1
公开(公告)日：2024-08-22
申请号：US18647560
申请日：2024-04-26
申请人： GENENTECH, INC.
发明人： Hem Raj GURUNG , Benjamin Joseph HALEY , Amy Jeane HEIDERSBACH , Juan LI , Christopher Michael ROSE , Ann-Jay TONG , Craig BLANCHETTE , Pamela Pui Fung CHAN , Martine Abraham DARWISH
CPC分类号： A61K35/17 , A61K39/0011 , A61K39/4611 , A61K39/4631 , A61K39/464414 , C07K14/70539 , C12N5/0636 , C12N5/0694 , G01N33/5044 , C12N2510/00
摘要： The present disclosure relates to compositions and methods of uses of a monoallelic MHC-expressing cell line, as well as method of identifying a neoepitope-MHIC binding pair and methods of treating a subject having a cancer or tumor expressing a neoantigen and a MHC allele.
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