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公开(公告)号:US20240277770A1
公开(公告)日:2024-08-22
申请号:US18647560
申请日:2024-04-26
申请人: GENENTECH, INC.
发明人: Hem Raj GURUNG , Benjamin Joseph HALEY , Amy Jeane HEIDERSBACH , Juan LI , Christopher Michael ROSE , Ann-Jay TONG , Craig BLANCHETTE , Pamela Pui Fung CHAN , Martine Abraham DARWISH
CPC分类号: A61K35/17 , A61K39/0011 , A61K39/4611 , A61K39/4631 , A61K39/464414 , C07K14/70539 , C12N5/0636 , C12N5/0694 , G01N33/5044 , C12N2510/00
摘要: The present disclosure relates to compositions and methods of uses of a monoallelic MHC-expressing cell line, as well as method of identifying a neoepitope-MHIC binding pair and methods of treating a subject having a cancer or tumor expressing a neoantigen and a MHC allele.
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公开(公告)号:US20230349903A1
公开(公告)日:2023-11-02
申请号:US18173002
申请日:2023-02-22
申请人: GENENTECH, INC.
发明人: Juan LI , Wilson PHUNG , Wendy Noel SANDOVAL , Whitney Lauren BINDER , Craig BLANCHETTE , Pamela Pui Fung CHAN , Martine Abraham DARWISH
IPC分类号: G01N33/569 , C07K14/74 , G01N33/68
CPC分类号: G01N33/56977 , C07K14/70539 , G01N33/6848 , G01N2333/70539 , G01N2800/24
摘要: The present disclosure relates to reagents and methods of making and for detecting MHCI/ligand peptide complexes.
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