公开(公告)号：US20240277770A1

公开(公告)日：2024-08-22

申请号：US18647560

申请日：2024-04-26

申请人： GENENTECH, INC.

发明人： Hem Raj GURUNG ,  Benjamin Joseph HALEY ,  Amy Jeane HEIDERSBACH ,  Juan LI ,  Christopher Michael ROSE ,  Ann-Jay TONG ,  Craig BLANCHETTE ,  Pamela Pui Fung CHAN ,  Martine Abraham DARWISH

IPC分类号： A61K35/17 ,  A61K39/00 ,  C07K14/74 ,  C12N5/0783 ,  C12N5/09 ,  G01N33/50

CPC分类号： A61K35/17 ,  A61K39/0011 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/464414 ,  C07K14/70539 ,  C12N5/0636 ,  C12N5/0694 ,  G01N33/5044 ,  C12N2510/00

摘要： The present disclosure relates to compositions and methods of uses of a monoallelic MHC-expressing cell line, as well as method of identifying a neoepitope-MHIC binding pair and methods of treating a subject having a cancer or tumor expressing a neoantigen and a MHC allele.

公开(公告)号：US20240042019A1

公开(公告)日：2024-02-08

申请号：US18485987

申请日：2023-10-12

申请人： Genentech, Inc.

发明人： Emily Crane FREUND ,  Anna-Maria HERZNER ,  Rebecca Ani LEYLEK ,  Ann-Jay TONG ,  Sara Marie WICHNER ,  Lélia Yvonne DELAMARRE

IPC分类号： A61K39/39 ,  C12N15/113 ,  A61P37/02

CPC分类号： A61K39/39 ,  C12N15/1138 ,  A61P37/02 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/531

摘要： The present disclosure relates to immunomodulatory compositions that selectively activate TLR7, comprising an RNA ligand and a pharmaceutically acceptable carrier, as well as to in vitro and therapeutic uses of such immunomodulatory compositions.