发明公开
- 专利标题： SYSTEMS AND METHODS TO IDENTIFY MHC-ASSOCIATED ANTIGENS FOR THERAPEUTIC INTERVENTION
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申请号： US18647560申请日： 2024-04-26
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公开(公告)号： US20240277770A1公开(公告)日： 2024-08-22
- 发明人: Hem Raj GURUNG , Benjamin Joseph HALEY , Amy Jeane HEIDERSBACH , Juan LI , Christopher Michael ROSE , Ann-Jay TONG , Craig BLANCHETTE , Pamela Pui Fung CHAN , Martine Abraham DARWISH
- 申请人： GENENTECH, INC.
- 申请人地址： US CA South San Francisco
- 专利权人： GENENTECH, INC.
- 当前专利权人： GENENTECH, INC.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; A61K39/00 ; C07K14/74 ; C12N5/0783 ; C12N5/09 ; G01N33/50
摘要：
The present disclosure relates to compositions and methods of uses of a monoallelic MHC-expressing cell line, as well as method of identifying a neoepitope-MHIC binding pair and methods of treating a subject having a cancer or tumor expressing a neoantigen and a MHC allele.
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