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公开(公告)号：US20240279354A1
公开(公告)日：2024-08-22
申请号：US18626607
申请日：2024-04-04
CPC分类号： C07K16/30 , A61P35/00 , C07K14/00 , C07K16/2809 , C12N5/0693 , A61K38/00 , A61K2039/505 , A61K2039/54 , A61K2039/545 , A61K2039/572 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/60 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/01 , C07K2319/035 , C07K2319/21 , C07K2319/30 , C07K2319/31 , C07K2319/50 , C12N2523/00
摘要： The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.
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公开(公告)号：US20230312729A1
公开(公告)日：2023-10-05
申请号：US17621978
申请日：2020-06-25
CPC分类号： C07K16/2863 , A61P35/00 , C07K16/2809 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2319/50
摘要： The present disclosure related to antigen-binding units that specifically bind to EGFR or epitopes thereof. Some embodiments include bispecific anti-EGFR/anti-CD3 constructs with improved expression and/or stability. Related methods are also disclosed.
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公开(公告)号：US20230265146A1
公开(公告)日：2023-08-24
申请号：US18073935
申请日：2022-12-02
发明人： Volker SCHELLENBERGER , Eric JOHANSEN , Angela HENKENSIEFKEN , Bryan IRVING , Tracy YOUNG , Vibha CHAUHAN , Valentine YEUNG
CPC分类号： C07K14/5434 , C07K14/001 , A61P35/00 , C07K2319/33
摘要： The present invention relates to compositions comprising biologically active proteins, such as cytokines, linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of related disorders and conditions.
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公开(公告)号：US12060424B2
公开(公告)日：2024-08-13
申请号：US16954145
申请日：2018-12-20
发明人： Fan Yang , Volker Schellenberger , Vladimir Podust , Bee-Cheng Sim , Desiree Thayer , John Beaber
CPC分类号： C07K16/2809 , A61P35/00 , C07K16/30 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/92
摘要： The present invention relates to activatable recombinant polypeptide compositions comprising a cleavage release segment. In some instances, the activatable recombinant polypeptide compositions include an XTEN linked to binding moieties by cleavable release segments that, when cleaved, the binding moieties are capable of binding together effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable activatable recombinant compositions.
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公开(公告)号：US20230322922A1
公开(公告)日：2023-10-12
申请号：US18064253
申请日：2022-12-10
发明人： Volker SCHELLENBERGER , Eric JOHANSEN , Angela HENKENSIEFKEN , Darragh MACCANN , James MCCLORY , Philipp KUHN , Andre FRENZEL , Milton TO , Michael FOX , Bryan IRVING , Mika DERYNCK
CPC分类号： C07K16/2809 , C07K16/32 , C07K16/2818 , C07K16/2827 , A61P35/00 , C12N15/70 , C07K2317/31 , C07K2319/30 , C12N2800/101
摘要： Disclosed herein are polypeptides, and methods of making and using such polypeptides, that comprise a bispecific antibody construct covalently linked to an extended recombinant polypeptide comprising a barcode fragment releasable from said polypeptide upon digestion by a protease, and a Release Segment that can be proteolytically cleaved wherein said cleavage releases the bispecific antibody construct from the extended recombinant polypeptide.
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公开(公告)号：US20240091315A1
公开(公告)日：2024-03-21
申请号：US18182954
申请日：2023-03-13
发明人： Volker Schellenberger , Vladimir Podust , Chia-Wei Wang , Bryant McLaughlin , Bee-Cheng Sim , Sheng Ding , Chen Gu
CPC分类号： A61K38/24 , A61K47/64 , A61K49/0032 , A61K49/0052 , A61K49/0056 , C07K5/0205
摘要： The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
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7.发明公开公开(公告)号：US20230287040A1
公开(公告)日：2023-09-14
申请号：US17776478
申请日：2020-11-13
CPC分类号： C07K1/13 , C07K14/001 , G01N33/6848 , C12N15/70 , G01N2333/95 , C12N2800/101
摘要： Disclosed herein are polypeptides comprising an extended recombinant polypeptide (XTEN) comprised of a plurality of overlapping sequence motifs and one or more barcode fragments releasable upon protease digestion and detectable from ail other proteolytic-ally releasable fragments. Certain embodiments of these polypeptides further comprise a biologically active polypeptide, wherein advantageous embodiments thereof comprise a releasable segment capable of proteolytic cleavage that cleaves the linkage between the XTEN polypeptide and the biologically active polypeptide. Methods of making and methods of using said polypeptides are also disclosed.
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公开(公告)号：US11713358B2
公开(公告)日：2023-08-01
申请号：US15753716
申请日：2016-08-26
CPC分类号： C07K16/30 , A61P35/00 , C07K14/00 , C07K16/2809 , A61K38/00 , A61K2039/505 , A61K2039/54 , A61K2039/545 , A61K2039/572 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/60 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/01 , C07K2319/035 , C07K2319/21 , C07K2319/30 , C07K2319/31 , C07K2319/50
摘要： The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.
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公开(公告)号：US20210164011A1
公开(公告)日：2021-06-03
申请号：US17036396
申请日：2020-09-29
发明人： Volker Schellenberger , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P.C. Stemmer , Nathan C. Geething
IPC分类号： C12P21/02 , C07K16/40 , C07K16/28 , C07K14/00 , C07K16/24 , C07K14/705 , C07K16/32 , C07K14/715 , C07K14/81 , C07K16/18 , C12N15/62 , A61K38/00
摘要： The present invention relates to binding fusion protein compositions comprising targeting moieties linked to extended recombinant polypeptide (XTEN), binding fusion protein-drug conjugate compositions, and XTEN-drug conjugate compositions, isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of diseases, disorders, and conditions.
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公开(公告)号：US20240067695A1
公开(公告)日：2024-02-29
申请号：US18330032
申请日：2023-06-06
发明人： Volker SCHELLENBERGER , Joshua SILVERMAN , Willem P. STEMMER , Chia-wei WANG , Nathan GEETHING , Benjamin SPINK
IPC分类号： C07K14/605
CPC分类号： C07K14/605 , A61K38/00 , C07K2319/31
摘要： The present invention relates to compositions comprising GLP-2 protein or variants thereof linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in the treatment of GLP-2 related conditions.
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