- 专利标题： Chimeric polypeptide assembly and methods of making and using the same
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申请号： US15753716申请日： 2016-08-26
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公开(公告)号： US11713358B2公开(公告)日： 2023-08-01
- 发明人: Volker Schellenberger , Fan Yang , Desiree Thayer , Bee-Cheng Sim , Chia-Wei Wang
- 申请人： AMUNIX PHARMACEUTICALS, INC.
- 申请人地址： US CA South San Francisco
- 专利权人： AMUNIX PHARMACEUTICALS, INC.
- 当前专利权人： AMUNIX PHARMACEUTICALS, INC.
- 当前专利权人地址： US CA South San Francisco
- 代理机构： Lathrop GPM LLP
- 代理商 James H. Velema, Esq.
- 国际申请： PCT/US2016/049137 2016.08.26
- 国际公布： WO2017/040344A 2017.03.09
- 进入国家日期： 2018-02-20
- 主分类号： C07K16/30
- IPC分类号： C07K16/30 ; C07K16/28 ; A61P35/00 ; C07K14/00 ; A61K39/00 ; A61K38/00
摘要：
The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.
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