公开(公告)号：US11713358B2

公开(公告)日：2023-08-01

申请号：US15753716

申请日：2016-08-26

Applicant: AMUNIX PHARMACEUTICALS, INC.

Inventor： Volker Schellenberger ,  Fan Yang ,  Desiree Thayer ,  Bee-Cheng Sim ,  Chia-Wei Wang

IPC: C07K16/30 ,  C07K16/28 ,  A61P35/00 ,  C07K14/00 ,  A61K39/00 ,  A61K38/00

CPC classification number: C07K16/30 ,  A61P35/00 ,  C07K14/00 ,  C07K16/2809 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/572 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/01 ,  C07K2319/035 ,  C07K2319/21 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/50

Abstract: The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.

公开(公告)号：US12060424B2

公开(公告)日：2024-08-13

申请号：US16954145

申请日：2018-12-20

Applicant: AMUNIX PHARMACEUTICALS, INC.

Inventor： Fan Yang ,  Volker Schellenberger ,  Vladimir Podust ,  Bee-Cheng Sim ,  Desiree Thayer ,  John Beaber

IPC: C07K16/00 ,  A61P35/00 ,  C07K16/28 ,  C07K16/30

CPC classification number: C07K16/2809 ,  A61P35/00 ,  C07K16/30 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92

Abstract: The present invention relates to activatable recombinant polypeptide compositions comprising a cleavage release segment. In some instances, the activatable recombinant polypeptide compositions include an XTEN linked to binding moieties by cleavable release segments that, when cleaved, the binding moieties are capable of binding together effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable activatable recombinant compositions.

公开(公告)号：US11981744B2

公开(公告)日：2024-05-14

申请号：US18067948

申请日：2022-12-19

Applicant: AMUNIX PHARMACEUTICALS, INC.

Inventor： Volker Schellenberger ,  Fan Yang ,  Desiree Thayer ,  Bee-Cheng Sim ,  Chia-Wei Wang

IPC: C07K16/30 ,  A61P35/00 ,  C07K14/00 ,  C07K16/28 ,  C12N5/09 ,  A61K38/00 ,  A61K39/00

CPC classification number: C07K16/30 ,  A61P35/00 ,  C07K14/00 ,  C07K16/2809 ,  C12N5/0693 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/572 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/01 ,  C07K2319/035 ,  C07K2319/21 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/50 ,  C12N2523/00

Abstract: The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.