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    Twin Immune Cell Engager
    5.
    发明公开
    Twin Immune Cell Engager 审中-公开

    公开(公告)号：US20230399415A1

    公开(公告)日：2023-12-14

    申请号：US18326248

    申请日：2023-05-31

    申请人： Revitope Limited

    发明人： Martin PREYER ,  Allison COLTHART ,  Pamela WEINSTEIN ,  Patrick WIENCEK ,  Emma GEIGER ,  Werner MEIER

    IPC分类号： C07K16/32 ,  A61P35/00 ,  C07K16/30

    CPC分类号： C07K16/32 ,  A61P35/00 ,  C07K16/30 ,  C07K2317/31 ,  C07K2317/73 ,  C07K2319/035 ,  C07K2319/74

    摘要： A Twin Immune Cell Engager (TWICE) is a kit or composition for treating cancer comprising a first component and second component. Each component comprises a targeting moiety that binds a tumor antigen expressed by the cancer or an antigen expressed by a non-cancer cell in the tumor microenvironment. In some embodiments, the first and second components each comprise an immune cell binding domain capable of immune cell binding activity when binding the immune cell binding domain in the other component, and a complementary binding domain capable of binding to a complementary antigen when binding the complementary binding domain in the other component. In some embodiments, the first and/or second components comprise a complementary functional domain with activity when targeted to the cancer cell or its microenvironment.
    The present TWICE complexes offer a unique ability to combine multiple functions into a two-component complex that becomes activated in the tumor microenvironment. The present complexes, thus, provide meaningful advantages in having a single approach to administering a two-component complex that is localized to the tumor microenvironment and has the ability to effect two different signals to benefit patients. This unique construct offers benefits that were not present in prior art constructs.