公开(公告)号：US20240287468A1

公开(公告)日：2024-08-29

申请号：US18570436

申请日：2022-06-14

申请人： Ferring B.V.

发明人： Kristin WANNERBERGER ,  Alexander SULAKVELIDZE

IPC分类号： C12N7/00 ,  A61K35/741 ,  A61K35/76 ,  A61K36/064 ,  A61K39/00 ,  A61K39/09 ,  A61P31/04

CPC分类号： C12N7/00 ,  A61K35/741 ,  A61K35/76 ,  A61K36/064 ,  A61K39/09 ,  A61P31/04 ,  A61K2039/521 ,  C12N2795/00021 ,  C12N2795/00032

摘要： Described herein are bacteriophages that infect and lyse Vancomycin-Resistant Enterococci (VRE). The bacteriophages are useful, for example, for the prophylactic or therapeutic treatment of subjects infected with Enterococci, including VRE, or who are at risk of infection by Enterococci, including VRE, and for other uses described herein.

公开(公告)号：US20240245065A1

公开(公告)日：2024-07-25

申请号：US18003622

申请日：2022-08-11

申请人： PHAGELAB CHILE SPA ,  AGROSUPER COMERCIALIZADORA DE ALIMENTOS LTDA

发明人： Mauro CANAVAL ALFARO ,  Daniel TICHY NAVARRO ,  Matias Cristobal AGUILERA BARRIOS ,  Michael PINO BARRIENTOS ,  Rodrigo Andres NORAMBUENA VENEGAS ,  Maria Sofia ZAMUDIO CANAS ,  Pablo CIFUENTES PALMA ,  Hans PIERINGER CASTRO ,  Andrea Katherine LILLO SILVA ,  Juan Carlos CARRENO PALMA

IPC分类号： A23B4/22 ,  A23L3/3463 ,  C12N7/00

CPC分类号： A23B4/22 ,  A23L3/34635 ,  C12N7/00 ,  C12N2795/00021

摘要： A formulation comprising a Pseudomonas-specific bacteriophage cocktail, useful for the prevention, reduction and/or treatment of infections caused by this bacterium through food contamination, particularly meat products. More specifically, the formulations for use in the food industry comprising at least one or more bacteriophages specific against Pseudomonas lundensis, where these are in combination with buffers, vehicles and/or acceptable excipients for the food industry.

公开(公告)号：US11873524B2

公开(公告)日：2024-01-16

申请号：US16247486

申请日：2019-01-14

申请人： Laboratory Corporation of America Holdings

发明人： Stephen Erickson ,  Jose S. Gil ,  Minh Mindy Bao Nguyen ,  Dwight Lyman Anderson ,  Jessica Stach

IPC分类号： C12Q1/10 ,  C12N15/86 ,  C12N15/65 ,  C12Q1/70 ,  G01N33/50 ,  C12Q1/66 ,  A61K35/76 ,  C12N15/74 ,  C12N7/00 ,  C12Q1/6897 ,  C12Q1/02

CPC分类号： C12Q1/10 ,  A61K35/76 ,  C12N7/00 ,  C12N15/65 ,  C12N15/74 ,  C12N15/86 ,  C12Q1/025 ,  C12Q1/66 ,  C12Q1/6897 ,  C12Q1/70 ,  G01N33/50 ,  C12N2795/00021 ,  C12N2795/00031 ,  C12N2795/00051 ,  C12N2795/10131 ,  C12N2795/10143 ,  C12Q2304/60 ,  G01N2800/52

摘要： Disclosed herein are methods and systems for rapid detection of microorganisms in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as Salmonella-specific bacteriophage, allows detection of a specific microorganism, such as Salmonella spp. and an indicator signal may be amplified to optimize assay sensitivity.

公开(公告)号：US20230416694A1

公开(公告)日：2023-12-28

申请号：US18315255

申请日：2023-05-10

申请人： Phico Therapeutics Ltd

发明人： Heather FAIRHEAD ,  Adam WILKINSON

IPC分类号： C12N7/00 ,  A61K39/07 ,  A61K39/104 ,  A61K35/76

CPC分类号： C12N7/00 ,  A61K39/07 ,  A61K39/104 ,  A61K35/76 ,  C12N2795/00021 ,  C12N2795/00032 ,  C12N2795/10121 ,  C12N2795/00031 ,  C12N2795/10132 ,  C12N2795/10131 ,  C12N2795/00043 ,  C12N2795/00045

摘要： A modified bacteriophage capable of infecting a plurality of different target bacteria, which bacteriophage includes a toxin gene encoding a toxin protein which is toxic to the target bacteria; wherein the bacteriophage is lytic; and wherein the bacteriophage expresses host range determinant proteins which have a plurality of bacterial host specificities.

公开(公告)号：US20230348952A1

公开(公告)日：2023-11-02

申请号：US18350263

申请日：2023-07-11

申请人： Laboratory Corporation of America Holdings

发明人： Stephen Erickson ,  Jose S. Gil ,  Minh Mindy Bao Nguyen ,  Wendy S. Hahn

IPC分类号： C12Q1/10 ,  C12N7/00 ,  C12Q1/66

CPC分类号： C12Q1/10 ,  C12N7/00 ,  C12Q1/66 ,  C12N2795/00021

摘要： Disclosed herein are compositions, methods, kits and systems for rapid detection of microorganisms using a reproduction-deficient indicator bacteriophage. The specificity of such reproduction-deficient indicator bacteriophage for binding and infecting particular microorganisms of interest allows targeted and sensitive detection of a microorganism of interest.

公开(公告)号：US11779617B2

公开(公告)日：2023-10-10

申请号：US17153911

申请日：2021-01-21

申请人： PHERECYDES PHARMA

发明人： Flavie Pouillot ,  Helene Blois

IPC分类号： A61K35/76 ,  C12N7/00

CPC分类号： A61K35/76 ,  C12N7/00 ,  C12N2795/00021 ,  C12N2795/00032 ,  C12N2795/10121 ,  C12N2795/10132 ,  C12N2795/10221 ,  C12N2795/10232

摘要： The present invention relates to bacteriophage therapy. More particularly, the present invention relates to novel bacteriophages having a high specificity against Pseudomonas aeruginosa strains, their manufacture, components thereof, compositions comprising the same and the uses thereof in phage therapy.

公开(公告)号：US20230285508A1

公开(公告)日：2023-09-14

申请号：US18198519

申请日：2023-05-17

申请人： SynPhaGen LLC

发明人： Todd Bernard Parsley ,  Christian Furlan Freguia

IPC分类号： A61K38/20 ,  C02F3/34 ,  A61K38/45 ,  C12N15/113 ,  C12N15/86 ,  A61K38/48 ,  C12N15/11 ,  A61K48/00 ,  C12N15/70 ,  C12N7/00

CPC分类号： A61K38/2066 ,  C02F3/34 ,  A61K38/45 ,  C12N15/113 ,  C12N15/86 ,  C12Y203/02013 ,  A61K38/482 ,  C12N15/111 ,  A61K48/005 ,  C12N15/70 ,  C12N7/00 ,  C12Y201/02001 ,  C12N2310/14 ,  C12N2795/00031 ,  C12N2320/32 ,  C12N2330/50 ,  C12N2795/00032 ,  C12N2795/00021 ,  C12N2820/55 ,  C12N2795/14143 ,  C12N2795/00043 ,  C12N2310/531

摘要： Compositions for a phage particle are disclosed. The phage particle is non-replicating and includes at least one heterologous nucleic acid sequence that is capable of being expressed in a target bacteria. The expressed heterologous nucleic acid sequence is non-lethal to the target bacteria.

公开(公告)号：US20190203185A1

公开(公告)日：2019-07-04

申请号：US16359677

申请日：2019-03-20

申请人： Altria Client Services LLC ,  Micreos BV

发明人： Dongmei Xu ,  Elisabeth Miller ,  James Arthur Strickland ,  Ujwala Warek ,  Steven Hagens

IPC分类号： C12N7/00 ,  C12N9/36 ,  C07K14/005 ,  A24B15/20

CPC分类号： C12N7/00 ,  A24B15/20 ,  C07K14/005 ,  C12N9/2462 ,  C12N2795/00021 ,  C12N2795/00022 ,  C12N2795/00031 ,  C12N2795/12031 ,  C12Y302/01017

摘要： Bacteriophage are provided, and methods of making and using the bacteriophage also are provided.

公开(公告)号：US09938506B2

公开(公告)日：2018-04-10

申请号：US14770328

申请日：2014-02-25

申请人： CJ CHEILJEDANG CORPORATION

发明人： Hyo Seel Seo ,  Eun Mi Shin ,  Gi Duk Bae ,  Jae Won Kim

IPC分类号： C12N7/00 ,  A61K35/76 ,  A01N63/00 ,  C11D3/48 ,  A23K50/75

CPC分类号： C12N7/00 ,  A01N63/00 ,  A23K50/75 ,  A61K35/76 ,  C11D3/48 ,  C12N2795/00021 ,  C12N2795/00031 ,  C12N2795/00032 ,  C12N2795/10221 ,  C12N2795/10222 ,  C12N2795/10231 ,  Y02A50/473

摘要： Provided is a novel bacteriophage ΦCJ23 (KCCM11365P). In addition, the present invention relates to an antibacterial composition including the bacteriophage ΦCJ23 (KCCM11365P) as an active ingredient. Further, provided is a method of preventing and/or treating infectious diseases by avian pathogenic Escherichia coli (APEC) in birds using the bacteriophage ΦCJ23 (KCCM11365P) or the antibacterial composition containing the bacteriophage ΦCJ23 (KCCM11365P) as an active ingredient.

公开(公告)号：US20170368116A1

公开(公告)日：2017-12-28

申请号：US15628368

申请日：2017-06-20

申请人： United States of America as Represented by the Secretary of the Navy

发明人： James M Regeimbal ,  Biswajit Biswas ,  Matthew S. Henry

IPC分类号： A61K35/76 ,  C12N7/00 ,  C12Q1/18

CPC分类号： A61K35/76 ,  C12N7/00 ,  C12N2795/00021 ,  C12N2795/00032 ,  C12N2795/00051 ,  C12N2795/10121 ,  C12N2795/10132 ,  C12Q1/18 ,  C40B30/04 ,  G01N2500/10

摘要： The subject matter of the instant invention relates to methods of compounding compositions comprising bacteriophage effective for treating bacterial infections, including but not limited to, multidrug resistant bacterial infections. The invention also relates to compositions, bacterial diversity sets, and phage libraries prepared according to the methods of the instant invention.