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公开(公告)号：US20240301343A1
公开(公告)日：2024-09-12
申请号：US18670411
申请日：2024-05-21
发明人： Carlos F. Gonzalez , Stephen J. Ahern , Mayukh Das , Ryland F. Young, III , Tushar Suvra Bhowmick
CPC分类号： C12N1/00 , A01N63/40 , C12N7/00 , C12N15/8281 , C12N2795/10121 , C12N2795/10131 , C12N2795/10221 , C12N2795/10231 , C12N2795/10321 , C12N2795/10331 , C12R2001/91
摘要： Methods and compositions are provided for preventing or reducing symptoms or disease associated with Xylella fastidiosa or Xanthomonas axonopodis in a plant. The invention provides novel bacteriophages virulent to Xylella fastidiosa or Xanthomonas axonopodis, including XfaMija and XfaMijo, and further provides methods for treating or preventing Pierce's Disease or Citrus Canker in plants.
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公开(公告)号：US20240182869A1
公开(公告)日：2024-06-06
申请号：US18285729
申请日：2022-04-08
申请人： APARON LTD.
发明人： Joseph Charles Samuel BROWN , Joseph Riziero EDWARDS , Sammy James KAY , Ellen Olivia DENNESS , Christopher Jeremy STANFORD
CPC分类号： C12N7/00 , A23K10/16 , A61K35/76 , A61P31/04 , C12Q1/04 , C12N2795/10121 , C12N2795/10132 , C12N2795/10221 , C12N2795/10232 , C12N2795/10321 , C12N2795/10332
摘要： The invention relates to the field of phage therapy. It particularly relates to providing phages, phage-based compositions and methods for treating or preventing bacterial infections, particularly C. perfringens, in animals, including humans, aquaculture and livestock. The invention also relates to uses of the compositions as a feedstuff and as a biological decontaminator in feed and food products for human and animal consumption.
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公开(公告)号：US11976265B2
公开(公告)日：2024-05-07
申请号：US17497582
申请日：2021-10-08
发明人： Carlos F. Gonzalez , Stephen J. Ahern , Mayukh Das , Ryland F. Young, III , Tushar Suvra Bhowmick
CPC分类号： C12N1/00 , A01N63/40 , C12N7/00 , C12N15/8281 , C12N2795/10121 , C12N2795/10131 , C12N2795/10221 , C12N2795/10231 , C12N2795/10321 , C12N2795/10331 , C12R2001/91
摘要： Methods and compositions are provided for preventing or reducing symptoms or disease associated with Xylella fastidiosa or Xanthomonas axonopodis in a plant. The invention provides novel bacteriophages virulent to Xylella fastidiosa or Xanthomonas axonopodis, including XfaMija and XfaMijo, and further provides methods for treating or preventing Pierce's Disease or Citrus Canker in plants.
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公开(公告)号：US11913032B2
公开(公告)日：2024-02-27
申请号：US17099633
申请日：2020-11-16
CPC分类号： C12N7/00 , C12N9/22 , C12P19/34 , C12N2710/16121 , C12N2795/10221 , C12N2795/10222 , C12N2795/10321 , C12N2795/10322 , C12N2795/14121 , C12N2795/14122 , C12Y301/00
摘要： The present disclosure relates to a method of in vitro engineering of nucleic acids. This disclosure further relates to in vitro engineering of viral genomes and to the improvement of viral properties by in vitro genomic engineering of viral genomes. Specifically, the disclosure relates to in vitro viral genomic digestion using RNA-guided Cas9, the assembly of a recombinant genome by the insertion of a DNA or RNA fragment into the digested viral genome and transformation of a host cell with the recombinant genome. This method also related to in vitro engineering for error correction of nucleic acids.
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公开(公告)号：US10077431B2
公开(公告)日：2018-09-18
申请号：US15031763
申请日：2014-10-24
申请人： PHERECYDES PHARMA
发明人： Flavie Pouillot , Hélène Blois
IPC分类号： A01N63/00 , A61K39/12 , A61K39/00 , A61K39/285 , A61K39/275 , C12N7/00 , A61K35/76 , C07K14/005 , C12Q1/18
CPC分类号： C12N7/00 , A61K35/76 , C07K14/005 , C12N2795/10121 , C12N2795/10122 , C12N2795/10132 , C12N2795/10171 , C12N2795/10221 , C12N2795/10222 , C12N2795/10232 , C12N2795/10271 , C12Q1/18
摘要： The present invention relates to bacteriophage therapy. More particularly, the present invention relates to novel bacteriophages having a high specificity against Pseudomonas aeruginosa strains, their manufacture, components thereof, compositions comprising the same and the uses thereof in phage therapy.
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公开(公告)号：US09862935B2
公开(公告)日：2018-01-09
申请号：US14770420
申请日：2014-02-24
发明人： Eun Mi Shin , Gi Duk Bae , Jae Won Kim
IPC分类号： A01N63/00 , A61K35/76 , C12N7/00 , A23K20/195
CPC分类号： C12N7/00 , A01N63/00 , A23K20/195 , A61K35/76 , C12N2795/10221 , C12N2795/10231 , C12N2795/10233
摘要： Provided is a novel bacteriophage ΦCJ20 (KCCM11362P). In addition, the present invention relates to an antibacterial composition including the bacteriophage ΦCJ20 (KCCM11362P) as an active ingredient. Further, the present invention is a method of preventing and/or treating infectious diseases by enterotoxigenic Escherichia coli in animals except for humans using the bacteriophage ΦCJ20 (KCCM11362P) or the antibacterial composition containing the bacteriophage ΦCJ20 (KCCM11362P) as an active ingredient.
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7.发明申请Methods and Systems for Rapid Detection of Microorganisms using Infectious Agents 审中-公开使用传染剂快速检测微生物的方法和系统公开(公告)号：US20150218616A1
公开(公告)日：2015-08-06
申请号：US14625481
申请日：2015-02-18
IPC分类号： C12Q1/66
CPC分类号： C12Q1/66 , C12N15/86 , C12N2795/10121 , C12N2795/10131 , C12N2795/10143 , C12N2795/10221 , C12N2795/10231 , C12N2795/10243 , G01N33/569 , G01N33/56911 , G01N33/581
摘要： Disclosed herein are methods and systems for rapid detection of microorganisms in a sample, without culturing for enrichment of the microorganism. A modified bacteriophage is also disclosed which comprises a non-native indicator gene in the late gene region. The indicator product is not a fusion protein. The specificity of infectious agents allows a specific microorganism to be targeted, and an indicator signal may be amplified to optimize assay sensitivity.
摘要翻译： 本文公开了用于快速检测样品中微生物的方法和系统，而不培养用于富集微生物。 还公开了一种修饰的噬菌体，其包含晚期基因区域中的非天然指示基因。 指示剂不是融合蛋白。 感染剂的特异性允许特异性微生物被靶向，并且可以扩增指示信号以优化测定灵敏度。
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公开(公告)号：US12006531B2
公开(公告)日：2024-06-11
申请号：US16674876
申请日：2019-11-05
IPC分类号： C12Q1/66 , C12N15/86 , G01N33/569 , G01N33/58
CPC分类号： C12Q1/66 , C12N15/86 , G01N33/569 , G01N33/56911 , G01N33/581 , C12N2795/10121 , C12N2795/10131 , C12N2795/10143 , C12N2795/10221 , C12N2795/10231 , C12N2795/10243
摘要： Disclosed herein are methods and systems for rapid detection of microorganisms in a sample, without culturing for enrichment of the microorganism. A modified bacteriophage is also disclosed which comprises a non-native indicator gene in the late gene region. The indicator product is not a fusion protein. The specificity of infectious agents allows a specific microorganism to be targeted, and an indicator signal may be amplified to optimize assay sensitivity.
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公开(公告)号：US20230174954A1
公开(公告)日：2023-06-08
申请号：US17917543
申请日：2021-04-27
CPC分类号： C12N7/00 , A61K35/76 , A61P31/04 , A61K45/06 , C12N2795/10121 , C12N2795/10132 , C12N2795/10171 , C12N2795/10221 , C12N2795/10232 , C12N2795/10271
摘要： The present disclosure relates to bacteriophage and compositions capable of infecting and killing Pseudomonas, and use of the same for treating Pseudomonas, e.g. Pseudomonas aeruginosa, bacterial infections.
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公开(公告)号：US11667895B2
公开(公告)日：2023-06-06
申请号：US16865748
申请日：2020-05-04
发明人： Asma Hatoum , Shreyas Rao
CPC分类号： C12N7/00 , C12N9/2402 , C12Q1/70 , C12N2795/10121 , C12N2795/10131 , C12N2795/10143 , C12N2795/10221 , C12N2795/10231 , C12N2795/10243 , C12Y302/01036
摘要： Disclosed herein is an engineered bacteriophage comprising an indicator gene, wherein said indicator gene is an RNA aptamer or a green fluorescent protein (GFP) or GFP-like protein, and further wherein said indicator gene can indicate the presence of a microorganism, such as a bacterial infection. The engineered bacteriophage can be capable of infecting and killing the microorganism. The engineered microorganism can be in a composition for delivery to a subject, and can be in hyaluronic acid, for example. Also disclosed are methods of using the engineered bacteriophage to diagnose and/or treat a subject with a bacterial infection.
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