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公开(公告)号：US12060424B2
公开(公告)日：2024-08-13
申请号：US16954145
申请日：2018-12-20
发明人： Fan Yang , Volker Schellenberger , Vladimir Podust , Bee-Cheng Sim , Desiree Thayer , John Beaber
CPC分类号： C07K16/2809 , A61P35/00 , C07K16/30 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/92
摘要： The present invention relates to activatable recombinant polypeptide compositions comprising a cleavage release segment. In some instances, the activatable recombinant polypeptide compositions include an XTEN linked to binding moieties by cleavable release segments that, when cleaved, the binding moieties are capable of binding together effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable activatable recombinant compositions.
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公开(公告)号：US20230322922A1
公开(公告)日：2023-10-12
申请号：US18064253
申请日：2022-12-10
发明人： Volker SCHELLENBERGER , Eric JOHANSEN , Angela HENKENSIEFKEN , Darragh MACCANN , James MCCLORY , Philipp KUHN , Andre FRENZEL , Milton TO , Michael FOX , Bryan IRVING , Mika DERYNCK
CPC分类号： C07K16/2809 , C07K16/32 , C07K16/2818 , C07K16/2827 , A61P35/00 , C12N15/70 , C07K2317/31 , C07K2319/30 , C12N2800/101
摘要： Disclosed herein are polypeptides, and methods of making and using such polypeptides, that comprise a bispecific antibody construct covalently linked to an extended recombinant polypeptide comprising a barcode fragment releasable from said polypeptide upon digestion by a protease, and a Release Segment that can be proteolytically cleaved wherein said cleavage releases the bispecific antibody construct from the extended recombinant polypeptide.
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公开(公告)号：US20240279354A1
公开(公告)日：2024-08-22
申请号：US18626607
申请日：2024-04-04
CPC分类号： C07K16/30 , A61P35/00 , C07K14/00 , C07K16/2809 , C12N5/0693 , A61K38/00 , A61K2039/505 , A61K2039/54 , A61K2039/545 , A61K2039/572 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/60 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/01 , C07K2319/035 , C07K2319/21 , C07K2319/30 , C07K2319/31 , C07K2319/50 , C12N2523/00
摘要： The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.
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公开(公告)号：US20230312729A1
公开(公告)日：2023-10-05
申请号：US17621978
申请日：2020-06-25
CPC分类号： C07K16/2863 , A61P35/00 , C07K16/2809 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2319/50
摘要： The present disclosure related to antigen-binding units that specifically bind to EGFR or epitopes thereof. Some embodiments include bispecific anti-EGFR/anti-CD3 constructs with improved expression and/or stability. Related methods are also disclosed.
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公开(公告)号：US20230265146A1
公开(公告)日：2023-08-24
申请号：US18073935
申请日：2022-12-02
发明人： Volker SCHELLENBERGER , Eric JOHANSEN , Angela HENKENSIEFKEN , Bryan IRVING , Tracy YOUNG , Vibha CHAUHAN , Valentine YEUNG
CPC分类号： C07K14/5434 , C07K14/001 , A61P35/00 , C07K2319/33
摘要： The present invention relates to compositions comprising biologically active proteins, such as cytokines, linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of related disorders and conditions.
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6.发明公开公开(公告)号：US20240327538A1
公开(公告)日：2024-10-03
申请号：US18438106
申请日：2024-02-09
发明人： Viktoriya Dubrovskaya , Eric Johansen , Lucas Liu , Darragh MacCann , Volker Schellenberger , Milton To
CPC分类号： C07K16/3069 , A61P35/00 , C07K16/2809 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C07K2319/50
摘要： Provided herein are, inter alia, antigen-binding molecules with binding specificity to cluster of differentiation 3 T cell receptor (CD3), antigen-binding molecules with binding specificity to prostate-specific membrane antigen (PSMA), cleavable linker sequences, and protease-activatable bispecific fusion proteins such as protease-activatable T cell engagers, as well as uses and methods of treatment.
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公开(公告)号：US12071456B2
公开(公告)日：2024-08-27
申请号：US17150426
申请日：2021-01-15
发明人： Volker Schellenberger , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , Wayne To , Jeffrey L. Cleland
IPC分类号： C07K14/47 , C07K14/00 , C07K14/545 , C07K14/605 , C07K14/61 , C07K14/745 , C12N9/64
CPC分类号： C07K14/47 , C07K14/001 , C07K14/545 , C07K14/605 , C07K14/61 , C07K14/745 , C12N9/6437 , C12N9/644 , C07K2319/31 , C07K2319/35
摘要： The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.
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公开(公告)号：US11981744B2
公开(公告)日：2024-05-14
申请号：US18067948
申请日：2022-12-19
CPC分类号： C07K16/30 , A61P35/00 , C07K14/00 , C07K16/2809 , C12N5/0693 , A61K38/00 , A61K2039/505 , A61K2039/54 , A61K2039/545 , A61K2039/572 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/60 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/01 , C07K2319/035 , C07K2319/21 , C07K2319/30 , C07K2319/31 , C07K2319/50 , C12N2523/00
摘要： The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.
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公开(公告)号：US20240076378A1
公开(公告)日：2024-03-07
申请号：US18494007
申请日：2023-10-25
发明人： Volker SCHELLENBERGER , Eric JOHANSEN , Angela HENKENSIEFKEN , Darragh MACCANN , James MCCLORY , Philipp KUHN , Andre FRENZEL , Bryan IRVING , Mika DERYNCK
CPC分类号： C07K16/2809 , A61P35/00 , C07K16/2818 , C07K16/2827 , C07K16/32 , C12N15/70 , C07K2317/31 , C07K2319/30 , C12N2800/101
摘要： Disclosed herein are polypeptides, and methods of making and using such polypeptides, that comprise a bispecific antibody construct covalently linked to an extended recombinant polypeptide comprising a barcode fragment releasable from said polypeptide upon digestion by a protease, and a Release Segment that can be proteolytically cleaved wherein said cleavage releases the bispecific antibody construct from the extended recombinant polypeptide.
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公开(公告)号：US20230121775A1
公开(公告)日：2023-04-20
申请号：US17621993
申请日：2020-06-25
摘要： This disclosure relates to compositions having an antibody binding fragment that specifically binds to CD3 or an epitope thereof. Some embodiments include compositions and antibody binding fragments with increased stability. Bispecific fusion proteins including such antibody-binding fragments are also disclosed.
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