公开(公告)号：US20240279354A1

公开(公告)日：2024-08-22

申请号：US18626607

申请日：2024-04-04

申请人： AMUNIX PHARMACEUTICALS, INC.

发明人： Volker SCHELLENBERGER ,  Fan YANG ,  Desiree THAYER ,  Bee-Cheng SIM ,  Chia-Wei WANG

IPC分类号： C07K16/30 ,  A61K38/00 ,  A61K39/00 ,  A61P35/00 ,  C07K14/00 ,  C07K16/28 ,  C12N5/09

CPC分类号： C07K16/30 ,  A61P35/00 ,  C07K14/00 ,  C07K16/2809 ,  C12N5/0693 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/572 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/01 ,  C07K2319/035 ,  C07K2319/21 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/50 ,  C12N2523/00

摘要： The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.

公开(公告)号：US20240018260A1

公开(公告)日：2024-01-18

申请号：US18336486

申请日：2023-06-16

申请人： AMUNIX PHARMACEUTICALS, INC.

发明人： Volker SCHELLENBERGER ,  Fan YANG ,  Desiree THAYER ,  Bee-Cheng SIM ,  Chia-Wei WANG

IPC分类号： C07K16/30 ,  C07K16/28 ,  A61P35/00 ,  C07K14/00

CPC分类号： C07K16/30 ,  C07K16/2809 ,  A61P35/00 ,  C07K14/00 ,  C07K2317/31 ,  C07K2317/622 ,  A61K2039/505

摘要： The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.

公开(公告)号：US20230295334A1

公开(公告)日：2023-09-21

申请号：US18067948

申请日：2022-12-19

申请人： AMUNIX PHARMACEUTICALS, INC.

发明人： Volker SCHELLENBERGER ,  Fan YANG ,  Desiree THAYER ,  Bee-Cheng SIM ,  Chia-Wei WANG

IPC分类号： C07K16/30 ,  C07K16/28 ,  A61P35/00 ,  C12N5/09

CPC分类号： C07K16/30 ,  A61P35/00 ,  C07K16/2809 ,  C12N5/0693 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C12N2523/00

摘要： The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.