公开(公告)号：US20210164011A1

公开(公告)日：2021-06-03

申请号：US17036396

申请日：2020-09-29

申请人： Amunix Pharmaceuticals, Inc.

发明人： Volker Schellenberger ,  Joshua Silverman ,  Chia-wei Wang ,  Benjamin Spink ,  Willem P.C. Stemmer ,  Nathan C. Geething

IPC分类号： C12P21/02 ,  C07K16/40 ,  C07K16/28 ,  C07K14/00 ,  C07K16/24 ,  C07K14/705 ,  C07K16/32 ,  C07K14/715 ,  C07K14/81 ,  C07K16/18 ,  C12N15/62 ,  A61K38/00

摘要： The present invention relates to binding fusion protein compositions comprising targeting moieties linked to extended recombinant polypeptide (XTEN), binding fusion protein-drug conjugate compositions, and XTEN-drug conjugate compositions, isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of diseases, disorders, and conditions.

公开(公告)号：US12071456B2

公开(公告)日：2024-08-27

申请号：US17150426

申请日：2021-01-15

申请人： AMUNIX PHARMACEUTICALS, INC.

发明人： Volker Schellenberger ,  Joshua Silverman ,  Chia-wei Wang ,  Benjamin Spink ,  Willem P. Stemmer ,  Nathan Geething ,  Wayne To ,  Jeffrey L. Cleland

IPC分类号： C07K14/47 ,  C07K14/00 ,  C07K14/545 ,  C07K14/605 ,  C07K14/61 ,  C07K14/745 ,  C12N9/64

CPC分类号： C07K14/47 ,  C07K14/001 ,  C07K14/545 ,  C07K14/605 ,  C07K14/61 ,  C07K14/745 ,  C12N9/6437 ,  C12N9/644 ,  C07K2319/31 ,  C07K2319/35

摘要： The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.

公开(公告)号：US10961287B2

公开(公告)日：2021-03-30

申请号：US15887313

申请日：2018-02-02

申请人： Amunix Pharmaceuticals, Inc.

发明人： Volker Schellenberger ,  Joshua Silverman ,  Chia-wei Wang ,  Benjamin Spink ,  Willem P. Stemmer ,  Nathan Geething ,  Wayne To ,  Jeffrey L. Cleland

IPC分类号： C07K14/47 ,  C07K14/00 ,  C12N9/64 ,  C07K14/61 ,  C07K14/605 ,  C07K14/545 ,  C07K14/745

摘要： The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.