公开(公告)号：US20220306985A1

公开(公告)日：2022-09-29

申请号：US17750908

申请日：2022-05-23

申请人： Nissan Chemical Industries, Ltd. ,  Kyoto University

发明人： Taito NISHINO ,  Tatsuro KANAKI ,  Ayako OTANI ,  Koichiro SARUHASHI ,  Misayo Tomura ,  Takehisa IWAMA ,  Masato HORIKAWA ,  Norio NAKATSUJI ,  Tomomi OTSUJI

IPC分类号： C12N5/00 ,  G01N33/50 ,  C12N5/071 ,  C12N5/09

摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like

公开(公告)号：US20140106348A1

公开(公告)日：2014-04-17

申请号：US13949310

申请日：2013-07-24

申请人： Kyoto University ,  Nissan Chemical Industries, Ltd.

发明人： Taito NISHINO ,  Tatsuro KANAKI ,  Ayako OTANI ,  Koichiro SARUHASHI ,  Misayo Tomura ,  Takehisa IWAMA ,  Masato HORIKAWA ,  Norio NAKATSUJI ,  Tomomi OTSUJI

IPC分类号： G01N33/50 ,  C12N5/09 ,  C12N5/071

CPC分类号： C12N5/0043 ,  C12N5/005 ,  C12N5/067 ,  C12N5/0693 ,  C12N2500/14 ,  C12N2500/34 ,  C12N2531/00 ,  C12N2533/80 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/5044 ,  G01N33/5067

摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like.

摘要翻译： 本发明通过使用在液体介质中形成不确定结构的介质组合物提供包含悬浮状态的培养细胞和/或组织的细胞和/或组织的培养方法，所述结构均匀地分散在溶液中并基本保持 细胞和/或组织，而基本上不增加溶液的粘度，从而提供防止沉淀的效果等。

公开(公告)号：US20200208101A1

公开(公告)日：2020-07-02

申请号：US16801785

申请日：2020-02-26

申请人： Nissan Chemical Industries, Ltd. ,  Kyoto University

发明人： Taito NISHINO ,  Tatsuro KANAKI ,  Ayako OTANI ,  Koichiro SARUHASHI ,  Misayo Tomura ,  Takehisa IWAMA ,  Masato HORIKAWA ,  Norio NAKATSUJI ,  Tomomi OTSUJI

IPC分类号： C12N5/00 ,  G01N33/50 ,  C12N5/09 ,  C12N5/071

摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like

公开(公告)号：US20170175077A1

公开(公告)日：2017-06-22

申请号：US15448557

申请日：2017-03-02

申请人： Nissan Chemical Industries, Ltd. ,  Kyoto University

发明人： Taito NISHINO ,  Tatsuro KANAKI ,  Ayako OTANI ,  Koichiro SARUHASHI ,  Misayo Tomura ,  Takehisa IWAMA ,  Masato HORIKAWA ,  Norio NAKATSUJI ,  Tomomi OTSUJI

IPC分类号： C12N5/00

CPC分类号： C12N5/0043 ,  C12N5/005 ,  C12N5/067 ,  C12N5/0693 ,  C12N2500/14 ,  C12N2500/34 ,  C12N2531/00 ,  C12N2533/80 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/5044 ,  G01N33/5067

摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like

公开(公告)号：US20240279597A1

公开(公告)日：2024-08-22

申请号：US18603745

申请日：2024-03-13

申请人： Nissan Chemical Industries, Ltd. ,  Kyoto University

发明人： Taito NISHINO ,  Tatsuro KANAKI ,  Ayako OTANI ,  Koichiro SARUHASHI ,  Misayo TOMURA ,  Takehisa IWAMA ,  Masato HORIKAWA ,  Norio NAKATSUJI ,  Tomomi OTSUJI

IPC分类号： C12N5/00 ,  C12N5/071 ,  C12N5/09 ,  G01N33/50

CPC分类号： C12N5/0043 ,  C12N5/005 ,  C12N5/067 ,  C12N5/0693 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/5044 ,  G01N33/5067 ,  C12N2500/14 ,  C12N2500/34 ,  C12N2531/00 ,  C12N2533/80

摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like

公开(公告)号：US20170044491A1

公开(公告)日：2017-02-16

申请号：US15118481

申请日：2015-02-13

申请人： NISSAN CHEMICAL INDUSTRIES, LTD. ,  KYOTO UNIVERSITY

发明人： Makiko UMEZAKI ,  Takahiro KISHIOKA ,  Taito NISHINO ,  Ayako OTANI ,  Kenichiro KAMEI ,  Li LIU ,  Yong CHEN

IPC分类号： C12N5/00 ,  D01F1/10 ,  C08L33/12 ,  D04H1/728 ,  D04H1/4291 ,  C08L33/14 ,  D01D5/00 ,  D01F6/36

CPC分类号： C12N5/0068 ,  C08L33/06 ,  C08L33/12 ,  C08L33/14 ,  C08L2201/56 ,  C08L2203/12 ,  C12N2533/40 ,  C12N2537/00 ,  D01D5/003 ,  D01F1/10 ,  D01F6/36 ,  D01F6/52 ,  D04H1/4291 ,  D04H1/728 ,  D10B2509/00

摘要： A composition for producing a fiber, containing (A) a polymer compound containing a unit structure represented by the formula (1) and a unit structure represented by the formula (2), (B) a crosslinking agent, (C) an acid compound, and (D) a solvent wherein each symbol in the formulas (1) and (2) is as described in the DESCRIPTION.

摘要翻译： 其中式（1）和（2）中的每个符号如描述中所述。

公开(公告)号：US20160305044A1

公开(公告)日：2016-10-20

申请号：US15106463

申请日：2014-12-19

申请人： NISSAN CHEMICAL INDUSTRIES, LTD.

发明人： Takahiro KISHIOKA ,  Makiko UMEZAKI ,  Ayako OTANI

IPC分类号： D01F6/74 ,  D01D5/00 ,  D01D5/084

CPC分类号： D01F6/74 ,  D01D5/0007 ,  D01D5/003 ,  D01D5/084 ,  D01F6/76

摘要： The invention provides a fiber which is superior in safety, can be conveniently produced, and has organic solvent resistance, as well as a starting material composition for producing the fiber and a biocompatible material containing the fiber. The fiber is produced by spinning a composition containing (A) a condensation product obtained by condensing one or more kinds of a compound represented by the formula (1), and (B) an acid compound: wherein each symbol is as defined herein.

摘要翻译： 其中每个符号如本文所定义。

公开(公告)号：US20160201226A1

公开(公告)日：2016-07-14

申请号：US14915219

申请日：2014-08-29

申请人： NISSAN CHEMICAL INDUSTRIES, LTD.

发明人： Makiko UMEZAKI ,  Takahiro KISHIOKA ,  Taito NISHINO ,  Ayako OTANI

IPC分类号： D01F6/16 ,  D01D5/00 ,  D01D10/02 ,  C08L33/14

CPC分类号： D01F6/16 ,  C08F220/20 ,  C08L33/14 ,  C08L33/26 ,  C08L2203/12 ,  C08L2312/00 ,  D01D5/0007 ,  D01D5/003 ,  D01D10/02 ,  D01F6/02 ,  D01F6/36 ,  D04H1/728

摘要： The invention provides a composition for the production of a fiber having organic solvent resistance, a fiber obtained by spinning the composition, and a biocompatible material containing the fiber. The composition contains (A) a polymer compound containing a unit structure represented by the formula (1) wherein each symbol is as described herein, (B) a crosslinking agent, (C) an acid compound, and (D) a solvent.

摘要翻译： 本发明提供了一种用于生产具有耐溶剂性的纤维的组合物，通过纺丝该组合物获得的纤维，以及含有该纤维的生物相容性材料。 组合物含有（A）含有式（1）所示的单元结构的高分子化合物，其中各符号如本文所述，（B）交联剂，（C）酸化合物和（D）溶剂。

公开(公告)号：US20160122576A1

公开(公告)日：2016-05-05

申请号：US14896623

申请日：2014-06-09

申请人： NISSAN CHEMICAL INDUSTRIES, LTD.

发明人： Yoshiomi HIROI ,  Ayako OTANI ,  Takahiro KISHIOKA ,  Taito NISHINO ,  Tomoyuki OZAWA

IPC分类号： C09D133/14

CPC分类号： C09D133/14 ,  C08F230/02 ,  C08L43/02 ,  C08L101/02 ,  C09D5/16 ,  C09D143/02 ,  C09D201/02 ,  C12M23/20 ,  C08F220/34

摘要： This is to provide a coating film having a function of inhibiting adhesion of a biological substance, a method for manufacturing the coating film, a copolymer obtainable by polymerizing a specific monomer mixture, a composition for forming a coating film having a specific composition, a method for manufacturing a varnish containing a copolymer to be used as a raw material of the composition for forming a coating film which is used for forming said film, and a sol for forming the coating film. In particular, this is to provide a coating film obtained by the method comprising a process of applying a composition for forming a coating film which comprises a copolymer comprising a recurring unit containing an organic group of the formula (a) and a recurring unit containing an organic group of the formula (b) and a solvent onto a substrate; and a process of drying at a temperature of −200° C. to 200° C. (wherein Ua1, Ua2, Ub1, Ub2 and Ub3, and An− are as defined in the present specification and the claims).

摘要翻译： 这是提供具有抑制生物物质粘附的功能的涂膜，涂膜的制造方法，通过聚合特定的单体混合物得到的共聚物，具有特定组成的涂膜的形成用组合物， 用于制造含有共聚物的清漆，以及用于形成所述膜的用于形成涂膜的组合物的原料，以及用于形成涂膜的溶胶。 特别地，这是提供一种通过包括涂覆用于形成涂膜的组合物的方法获得的涂膜，该涂膜包括包含含有式（a）的有机基团的重复单元的共聚物和含有 式（b）的有机基团和溶剂在基材上; 和在-200℃至200℃的温度下干燥的方法（其中Ua1，Ua2，Ub1，Ub2和Ub3以及An-如本说明书和权利要求中所定义）。

公开(公告)号：US20180136196A1

公开(公告)日：2018-05-17

申请号：US15566981

申请日：2016-04-15

申请人： NISSAN CHEMICAL INDUSTRIES, LTD.

发明人： Natsuki ABE ,  Taito NISHINO ,  Ayako OTANI

IPC分类号： G01N33/50 ,  C12N5/00

CPC分类号： G01N33/5011 ,  C08B37/12 ,  C12N5/0018 ,  C12Q1/02

摘要： The invention provides a medium additive, medium composition and a culture method and the like, capable of efficiently culturing cells or tissues in a well dispersed state, and further, permitting cell image analysis of the cells or tissues. The medium additive or medium composition contains agar, which preferably is a low molecular weight agar having a weight average molecular weight of 10,000-60,000. Using same, cells or tissues can be cultured in a well-dispersed state in a medium, and a proliferation promoting effect for the cells or tissues can also be obtained. In addition, the cells can be cultured in any of a floating state and a precipitated state by adjusting the concentration of the aforementioned agar.