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公开(公告)号：US20220306985A1
公开(公告)日：2022-09-29
申请号：US17750908
申请日：2022-05-23
发明人： Taito NISHINO , Tatsuro KANAKI , Ayako OTANI , Koichiro SARUHASHI , Misayo Tomura , Takehisa IWAMA , Masato HORIKAWA , Norio NAKATSUJI , Tomomi OTSUJI
摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like
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2.发明申请CULTURE MEDIUM COMPOSITION AND METHOD OF CULTURING CELL OR TISSUE USING THEREOF 有权培养基组合物和使用其培养细胞或组织的方法公开(公告)号：US20140106348A1
公开(公告)日：2014-04-17
申请号：US13949310
申请日：2013-07-24
发明人： Taito NISHINO , Tatsuro KANAKI , Ayako OTANI , Koichiro SARUHASHI , Misayo Tomura , Takehisa IWAMA , Masato HORIKAWA , Norio NAKATSUJI , Tomomi OTSUJI
CPC分类号： C12N5/0043 , C12N5/005 , C12N5/067 , C12N5/0693 , C12N2500/14 , C12N2500/34 , C12N2531/00 , C12N2533/80 , G01N33/5011 , G01N33/5014 , G01N33/5044 , G01N33/5067
摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like.
摘要翻译： 本发明通过使用在液体介质中形成不确定结构的介质组合物提供包含悬浮状态的培养细胞和/或组织的细胞和/或组织的培养方法，所述结构均匀地分散在溶液中并基本保持 细胞和/或组织，而基本上不增加溶液的粘度，从而提供防止沉淀的效果等。
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公开(公告)号：US20200208101A1
公开(公告)日：2020-07-02
申请号：US16801785
申请日：2020-02-26
发明人： Taito NISHINO , Tatsuro KANAKI , Ayako OTANI , Koichiro SARUHASHI , Misayo Tomura , Takehisa IWAMA , Masato HORIKAWA , Norio NAKATSUJI , Tomomi OTSUJI
摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like
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公开(公告)号：US20170175077A1
公开(公告)日：2017-06-22
申请号：US15448557
申请日：2017-03-02
发明人： Taito NISHINO , Tatsuro KANAKI , Ayako OTANI , Koichiro SARUHASHI , Misayo Tomura , Takehisa IWAMA , Masato HORIKAWA , Norio NAKATSUJI , Tomomi OTSUJI
IPC分类号： C12N5/00
CPC分类号： C12N5/0043 , C12N5/005 , C12N5/067 , C12N5/0693 , C12N2500/14 , C12N2500/34 , C12N2531/00 , C12N2533/80 , G01N33/5011 , G01N33/5014 , G01N33/5044 , G01N33/5067
摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like
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公开(公告)号：US20170009201A1
公开(公告)日：2017-01-12
申请号：US15113762
申请日：2015-01-23
发明人： Hisato HAYASHI , Misayo OTANI , Koichiro SARUHASHI , Taito NISHINO , Takehisa IWAMA , Tatsuro KANAKI , Ayako AIHARA
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , C12N2533/70 , C12N2533/72 , C12N2533/78 , C12N2535/00
摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition having an effect of preventing sedimentation of cells and/or tissues, which is afforded by substantially retaining the cells and/or tissues without substantially increasing the viscosity of the solution by nanofibers which have been added to the solution and uniformly dispersed in the liquid medium, and the like.
摘要翻译： 本发明通过使用具有抑制细胞和/或组织沉淀的作用的培养基组合来提供包含培养细胞和/或悬浮状态的组织的细胞和/或组织的培养方法，所述培养基组合物通过基本上保持细胞 和/或组织，而基本上不会增加已经加入到溶液中并均匀分散在液体介质中的纳米纤维的溶液粘度等。
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公开(公告)号：US20240279597A1
公开(公告)日：2024-08-22
申请号：US18603745
申请日：2024-03-13
发明人： Taito NISHINO , Tatsuro KANAKI , Ayako OTANI , Koichiro SARUHASHI , Misayo TOMURA , Takehisa IWAMA , Masato HORIKAWA , Norio NAKATSUJI , Tomomi OTSUJI
CPC分类号： C12N5/0043 , C12N5/005 , C12N5/067 , C12N5/0693 , G01N33/5011 , G01N33/5014 , G01N33/5044 , G01N33/5067 , C12N2500/14 , C12N2500/34 , C12N2531/00 , C12N2533/80
摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like
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7.发明申请ACTIVE-ESTER-GROUP-CONTAINING COMPOSITION FOR PRODUCING FIBERS, AND CELL CULTURE SCAFFOLD MATERIAL USING FIBERS PRODUCED FROM ACTIVE-ESTER-GROUP-CONTAINING COMPOSITION 审中-公开用于生产纤维的含活性酯基的组合物和使用由含有活性酯基的组合物生产的纤维的细胞培养物质公开(公告)号：US20170044491A1
公开(公告)日：2017-02-16
申请号：US15118481
申请日：2015-02-13
发明人： Makiko UMEZAKI , Takahiro KISHIOKA , Taito NISHINO , Ayako OTANI , Kenichiro KAMEI , Li LIU , Yong CHEN
CPC分类号： C12N5/0068 , C08L33/06 , C08L33/12 , C08L33/14 , C08L2201/56 , C08L2203/12 , C12N2533/40 , C12N2537/00 , D01D5/003 , D01F1/10 , D01F6/36 , D01F6/52 , D04H1/4291 , D04H1/728 , D10B2509/00
摘要： A composition for producing a fiber, containing (A) a polymer compound containing a unit structure represented by the formula (1) and a unit structure represented by the formula (2), (B) a crosslinking agent, (C) an acid compound, and (D) a solvent wherein each symbol in the formulas (1) and (2) is as described in the DESCRIPTION.
摘要翻译： 其中式（1）和（2）中的每个符号如描述中所述。
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公开(公告)号：US20170002311A1
公开(公告)日：2017-01-05
申请号：US15113753
申请日：2015-01-23
发明人： Misayo OTANI , Koichiro SARUHASHI , Taito NISHINO , Ayako AIHARA , Hisashi ISHII , Keigo MATSUMOTO
CPC分类号： C12N5/0018 , C08B37/006 , C12N5/0025 , C12N2500/34
摘要： The present invention provides a production method of a medium composition, including previously removing divalent metal cations contained in a polymer compound having an anionic functional group, preparing a dry powder of the polymer compound, and mixing the dry powder and the medium, and the like. The present invention also provides a purification method of a polymer compound having an anionic functional group, which includes mixing a suspension of the polymer compound having an anionic functional group in water and a cation exchanger that exchanges a divalent metal cation with a monovalent metal cation to give a polymer compound having an anionic functional group, which shows a reduced amount of contaminating divalent metal cations.
摘要翻译： 本发明提供了一种介质组合物的制备方法，其包括预先除去具有阴离子官能团的高分子化合物中所含的二价金属阳离子，制备高分子化合物的干燥粉末，以及混合干燥粉末和介质等 。 本发明还提供了具有阴离子官能团的高分子化合物的纯化方法，该方法包括将水中具有阴离子官能团的高分子化合物的悬浮液和将二价金属阳离子与一价金属阳离子交换的阳离子交换剂混合 得到具有阴离子官能团的高分子化合物，其显示出减少量的污染二价金属阳离子。
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9.发明申请公开(公告)号：US20190002727A1
公开(公告)日：2019-01-03
申请号：US15741366
申请日：2016-07-01
发明人： Yoshiomi HIROI , Masahisa ENDO , Natsuki ABE , Taito NISHINO
IPC分类号： C09D143/02 , C08F230/02 , C08F220/36 , C09D133/16
摘要： The present invention is to provide a copolymer obtainable by polymerizing a monomer mixture containing at least compounds of the following formulae (A) and (B) (wherein Ta, Tb, Qa, Qb, Ra, Rb, Ua1, Ua2, Ua3, Ub1, Ub2, Ub3, An− and m are as defined in the present specification and Claims), etc. The copolymer of the present invention can be utilized as an ion complex material excellent in a function of inhibiting adhesion of a biological substance.
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公开(公告)号：US20140162318A1
公开(公告)日：2014-06-12
申请号：US13974820
申请日：2013-08-23
发明人： Misayo TOMURA , Takehisa IWAMA , Koichiro SARUHASHI , Taito NISHINO , Masato HORIKAWA , Hiroharu KAWAHARA
IPC分类号： C12P21/00
CPC分类号： C12P21/00 , C07K14/565 , C12N5/0018 , C12N2501/90 , C12N2511/00
摘要： [Summary] The present invention relates to a protein production accelerating agent that has enabled to largely increase the produced amount of a desired protein by adding polysaccharides to a medium for animal cells containing a serum or serum alternative, and a production method of a protein using a medium containing the protein production accelerating agent.
摘要翻译： 发明内容本发明涉及蛋白质生产促进剂，其能够通过向含有血清或血清替代物的动物细胞的培养基中添加多糖而大大增加所需蛋白质的产生量，以及使用 含有蛋白质生产促进剂的培养基。
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