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公开(公告)号：US20220262459A1
公开(公告)日：2022-08-18
申请号：US17735494
申请日：2022-05-03
摘要： The present disclosure provides methods and systems for identification of genomic regions for therapeutic targeting. A method for identifying one or more genomic regions for therapeutic targeting, which may facilitate re-programming of a cell from one phenotypic state to another, may comprise: providing single-cell RNA-seq data for a plurality of diseased cells and a plurality of normal cells of a cell type; mapping the single-cell RNA-seq data for the plurality of diseased cells and the plurality of normal cells into a latent space corresponding to a plurality of phenotypic states of the cell type; identifying, based at least in part on a topology of the latent space, the one or more genomic regions for therapeutic targeting; and electronically outputting the one or more genomic regions for therapeutic targeting.
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公开(公告)号：US11710536B2
公开(公告)日：2023-07-25
申请号：US17735494
申请日：2022-05-03
CPC分类号： G16B20/00 , C12N5/0693 , C12N5/0694 , C12N9/22 , C12N15/1058 , C12N15/1089 , C12N15/1096 , C12N15/11 , C12N15/86 , G06N20/00 , G16B40/20 , C12N2310/20 , C12N2740/15043 , C12N2800/80
摘要： The present disclosure provides methods and systems for identification of genomic regions for therapeutic targeting. A method for identifying one or more genomic regions for therapeutic targeting, which may facilitate re-programming of a cell from one phenotypic state to another, may comprise: providing single-cell RNA-seq data for a plurality of diseased cells and a plurality of normal cells of a cell type; mapping the single-cell RNA-seq data for the plurality of diseased cells and the plurality of normal cells into a latent space corresponding to a plurality of phenotypic states of the cell type; identifying, based at least in part on a topology of the latent space, the one or more genomic regions for therapeutic targeting; and electronically outputting the one or more genomic regions for therapeutic targeting.
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公开(公告)号：US20220254440A1
公开(公告)日：2022-08-11
申请号：US17556068
申请日：2021-12-20
摘要： The present disclosure provides methods and systems for identification of genomic regions for therapeutic targeting. A method for identifying one or more genomic regions for therapeutic targeting, which may facilitate re-programming of a cell from one phenotypic state to another, may comprise: providing single-cell RNA-seq data for a plurality of diseased cells and a plurality of normal cells of a cell type; mapping the single-cell RNA-seq data for the plurality of diseased cells and the plurality of normal cells into a latent space corresponding to a plurality of phenotypic states of the cell type; identifying, based at least in part on a topology of the latent space, the one or more genomic regions for therapeutic targeting; and electronically outputting the one or more genomic regions for therapeutic targeting.
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公开(公告)号：US20240290421A1
公开(公告)日：2024-08-29
申请号：US18206981
申请日：2023-06-07
CPC分类号： G16B20/00 , C12N5/0693 , C12N5/0694 , C12N9/22 , C12N15/1058 , C12N15/1089 , C12N15/1096 , C12N15/11 , C12N15/86 , G06N20/00 , G16B40/20 , C12N2310/20 , C12N2740/15043 , C12N2800/80
摘要： The present disclosure provides methods and systems for identification of genomic regions for therapeutic targeting. A method for identifying one or more genomic regions for therapeutic targeting, which may facilitate re-programming of a cell from one phenotypic state to another, may comprise: providing single-cell RNA-seq data for a plurality of diseased cells and a plurality of normal cells of a cell type; mapping the single-cell RNA-seq data for the plurality of diseased cells and the plurality of normal cells into a latent space corresponding to a plurality of phenotypic states of the cell type; identifying, based at least in part on a topology of the latent space, the one or more genomic regions for therapeutic targeting; and electronically outputting the one or more genomic regions for therapeutic targeting.
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公开(公告)号：US20230307086A1
公开(公告)日：2023-09-28
申请号：US18099526
申请日：2023-01-20
摘要： Methods and systems for determining an effectiveness of a drug (e.g., on- and off-target effects) may comprise: generating a latent space representation, which represents phenotypic states of a cell type, of nucleic acid sequence data for diseased and normal cells of the cell type; identifying, based at least in part on the latent space topology, a target genomic region; mapping sequence data of a first cell of the cell type, which has been modified, to the latent space to yield a first latent space representation; mapping sequence data of a second cell of the cell type, which has been exposed to the drug and exhibited the first phenotypic state before exposure, to the latent space to yield a second latent space representation; and determining, based at least in part on the first and second latent space representations, the effectiveness of the drug.
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