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公开(公告)号：US11710536B2
公开(公告)日：2023-07-25
申请号：US17735494
申请日：2022-05-03
CPC分类号： G16B20/00 , C12N5/0693 , C12N5/0694 , C12N9/22 , C12N15/1058 , C12N15/1089 , C12N15/1096 , C12N15/11 , C12N15/86 , G06N20/00 , G16B40/20 , C12N2310/20 , C12N2740/15043 , C12N2800/80
摘要： The present disclosure provides methods and systems for identification of genomic regions for therapeutic targeting. A method for identifying one or more genomic regions for therapeutic targeting, which may facilitate re-programming of a cell from one phenotypic state to another, may comprise: providing single-cell RNA-seq data for a plurality of diseased cells and a plurality of normal cells of a cell type; mapping the single-cell RNA-seq data for the plurality of diseased cells and the plurality of normal cells into a latent space corresponding to a plurality of phenotypic states of the cell type; identifying, based at least in part on a topology of the latent space, the one or more genomic regions for therapeutic targeting; and electronically outputting the one or more genomic regions for therapeutic targeting.
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公开(公告)号：US20220289725A1
公开(公告)日：2022-09-15
申请号：US17731943
申请日：2022-04-28
发明人： Andrei W. Konradi , Chun-Hao Huang , Ko-Chuan Lee
IPC分类号： C07D405/14
摘要： The present disclosure provides CDK9 inhibitors. Also provided are methods of treating a disease or a disorder comprising administering to a subject in need of treatment one of the CDK9 inhibitors disclosed herein. In some embodiments, the disease or disorder to be treated is cancer. In some embodiments, the disease or disorder is liver cancer.
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公开(公告)号：US11591322B2
公开(公告)日：2023-02-28
申请号：US17731943
申请日：2022-04-28
发明人： Andrei W. Konradi , Chun-Hao Huang , Ko-Chuan Lee
IPC分类号： C07D405/14
摘要： The present disclosure provides CDK9 inhibitors. Also provided are methods of treating a disease or a disorder comprising administering to a subject in need of treatment one of the CDK9 inhibitors disclosed herein. In some embodiments, the disease or disorder to be treated is cancer. In some embodiments, the disease or disorder is liver cancer.
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公开(公告)号：US20220262459A1
公开(公告)日：2022-08-18
申请号：US17735494
申请日：2022-05-03
摘要： The present disclosure provides methods and systems for identification of genomic regions for therapeutic targeting. A method for identifying one or more genomic regions for therapeutic targeting, which may facilitate re-programming of a cell from one phenotypic state to another, may comprise: providing single-cell RNA-seq data for a plurality of diseased cells and a plurality of normal cells of a cell type; mapping the single-cell RNA-seq data for the plurality of diseased cells and the plurality of normal cells into a latent space corresponding to a plurality of phenotypic states of the cell type; identifying, based at least in part on a topology of the latent space, the one or more genomic regions for therapeutic targeting; and electronically outputting the one or more genomic regions for therapeutic targeting.
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公开(公告)号：US20220254440A1
公开(公告)日：2022-08-11
申请号：US17556068
申请日：2021-12-20
摘要： The present disclosure provides methods and systems for identification of genomic regions for therapeutic targeting. A method for identifying one or more genomic regions for therapeutic targeting, which may facilitate re-programming of a cell from one phenotypic state to another, may comprise: providing single-cell RNA-seq data for a plurality of diseased cells and a plurality of normal cells of a cell type; mapping the single-cell RNA-seq data for the plurality of diseased cells and the plurality of normal cells into a latent space corresponding to a plurality of phenotypic states of the cell type; identifying, based at least in part on a topology of the latent space, the one or more genomic regions for therapeutic targeting; and electronically outputting the one or more genomic regions for therapeutic targeting.
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公开(公告)号：US20240290421A1
公开(公告)日：2024-08-29
申请号：US18206981
申请日：2023-06-07
CPC分类号： G16B20/00 , C12N5/0693 , C12N5/0694 , C12N9/22 , C12N15/1058 , C12N15/1089 , C12N15/1096 , C12N15/11 , C12N15/86 , G06N20/00 , G16B40/20 , C12N2310/20 , C12N2740/15043 , C12N2800/80
摘要： The present disclosure provides methods and systems for identification of genomic regions for therapeutic targeting. A method for identifying one or more genomic regions for therapeutic targeting, which may facilitate re-programming of a cell from one phenotypic state to another, may comprise: providing single-cell RNA-seq data for a plurality of diseased cells and a plurality of normal cells of a cell type; mapping the single-cell RNA-seq data for the plurality of diseased cells and the plurality of normal cells into a latent space corresponding to a plurality of phenotypic states of the cell type; identifying, based at least in part on a topology of the latent space, the one or more genomic regions for therapeutic targeting; and electronically outputting the one or more genomic regions for therapeutic targeting.
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公开(公告)号：US20230307086A1
公开(公告)日：2023-09-28
申请号：US18099526
申请日：2023-01-20
摘要： Methods and systems for determining an effectiveness of a drug (e.g., on- and off-target effects) may comprise: generating a latent space representation, which represents phenotypic states of a cell type, of nucleic acid sequence data for diseased and normal cells of the cell type; identifying, based at least in part on the latent space topology, a target genomic region; mapping sequence data of a first cell of the cell type, which has been modified, to the latent space to yield a first latent space representation; mapping sequence data of a second cell of the cell type, which has been exposed to the drug and exhibited the first phenotypic state before exposure, to the latent space to yield a second latent space representation; and determining, based at least in part on the first and second latent space representations, the effectiveness of the drug.
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公开(公告)号：US20230295135A1
公开(公告)日：2023-09-21
申请号：US18097782
申请日：2023-01-17
发明人： Andrei W. Konradi , Chun-Hao Huang , Ko-Chuan Lee
IPC分类号： C07D405/14
CPC分类号： C07D405/14
摘要： The present disclosure provides CDK9 inhibitors. Also provided are methods of treating a disease or a disorder comprising administering to a subject in need of treatment one of the CDK9 inhibitors disclosed herein. In some embodiments, the disease or disorder to be treated is cancer. In some embodiments, the disease or disorder is liver cancer.
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