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公开(公告)号：US20200269234A1
公开(公告)日：2020-08-27
申请号：US16352234
申请日：2019-03-13
申请人： EMULATE, Inc.
发明人： Ville Kujala , Hyoungshin Park , Sonalee Barthakur , Sauveur Jeanty , Brian Zuckerman , Josiah Sliz , Tanvi Shroff , Geraldine A. Hamilton , Kyung-Jin Jang , Ananth Nookala , Gang Luo , Donald Mckenzie
摘要： The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Chip.
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公开(公告)号：US20170285003A1
公开(公告)日：2017-10-05
申请号：US15474214
申请日：2017-03-30
申请人： EMULATE, INC.
发明人： Geraldine A. Hamilton , Norman Wen , Catherine Karalis , Antonio Varone , Daniel Levner , Riccardo Barrile
IPC分类号： G01N33/50
CPC分类号： C12M23/16 , C12M21/00 , C12M25/02 , C12N5/0693 , G01N33/5011 , G01N33/5017
摘要： The invention generally relates to a microfluidic platforms or “chips” for testing and understanding cancer, and, more specifically, for understanding the factors that contribute to cancer invading tissues and causing metastases. Tumor cells are grown on microfluidic devices with other non-cancerous tissues under conditions that simulate tumor invasion. The interaction with immune cells can be tested to inhibit this activity by linking a cancer chip to a lymph chip.
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公开(公告)号：US20210003559A1
公开(公告)日：2021-01-07
申请号：US16912391
申请日：2020-06-25
发明人： Cristina Bertinetti-Lapatki , Lauriane Cabon , Adrian B. Roth , Annie Moisan , Nikolche Gjorevski , Jordan S. Kerns , Geraldine A. Hamilton , Catherine Karalis , Heather Grant , Riccardo Barrile , Debora Barreiros Petropolis , Chaitra Belgur
IPC分类号： G01N33/50
摘要： Disclosed herein is a method for assessing a compound interacting with a target on polarized epithelial cells. The method comprising the steps of providing an organ chip comprising a main channel and polarized epithelial cells, wherein the main channel is divided into an apical channel and a basal channel separated by the polarized epithelial cells, wherein the apical side of the polarized epithelial cells is directed towards the apical channel and the basolateral side of the polarized epithelial cells is directed towards the basal channel. Determining the localization and optionally the expression level of the target on the polarized epithelial cells. Administering the compound and optionally immune cells, preferably peripheral blood mononuclear cells (PBMC) to the basal channel, when the target is localized on the basolateral side of the epithelial cells or administering the compound and optionally immune cells, preferably peripheral blood mononuclear cells (PBMC) to the apical channel, when the target is localized on the apical side of the epithelial cells. Measuring a parameter of the administration of the compound and the peripheral blood mononuclear cells.
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公开(公告)号：US20240344005A1
公开(公告)日：2024-10-17
申请号：US18631480
申请日：2024-04-10
申请人： EMULATE, Inc.
发明人： Geraldine A. Hamilton , Norman Wen , Catherine Karalis , Antonio Varone , Daniel Levner , Riccardo Barrile
CPC分类号： C12M23/16 , C12M25/02 , C12N5/0693 , G01N33/5011 , G01N33/5017
摘要： The invention generally relates to a microfluidic platforms or “chips” for testing and understanding cancer, and, more specifically, for understanding the factors that contribute to cancer invading tissues and causing metastases. Tumor cells are grown on microfluidic devices with other non-cancerous tissues under conditions that simulate tumor invasion. The interaction with immune cells can be tested to inhibit this activity by linking a cancer chip to a lymph chip.
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公开(公告)号：US11970680B2
公开(公告)日：2024-04-30
申请号：US16089220
申请日：2017-03-30
申请人： EMULATE, INC.
发明人： Geraldine A. Hamilton , Norman Wen , Catherine Karalis , Antonio Varone , Daniel Levner , Riccardo Barrile
CPC分类号： C12M23/16 , C12M25/02 , C12N5/0693 , G01N33/5011 , G01N33/5017
摘要： The invention generally relates to a microfluidic platforms or “chips” for testing and understanding cancer, and, more specifically, for understanding the factors that contribute to cancer invading tissues and causing metastases. Tumor cells are grown on microfluidic devices with other non-cancerous tissues under conditions that simulate tumor invasion. The interaction with immune cells can be tested to inhibit this activity by linking a cancer chip to a lymph chip.
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公开(公告)号：US20220282194A1
公开(公告)日：2022-09-08
申请号：US17725034
申请日：2022-04-20
申请人： EMULATE, INC.
发明人： Geraldine A. Hamilton , Norman Wen , Catherine Karalis , Antonio Varone , Daniel Levner , Riccardo Barrile
摘要： The invention generally relates to a microfluidic platforms or “chips” for testing and understanding cancer, and, more specifically, for understanding the factors that contribute to cancer invading tissues and causing metastases. Tumor cells are grown on microfluidic devices with other non-cancerous tissues under conditions that simulate tumor invasion. The interaction with immune cells can be tested to inhibit this activity by linking a cancer chip to a lymph chip.
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公开(公告)号：US20200270582A1
公开(公告)日：2020-08-27
申请号：US16454753
申请日：2019-06-27
申请人： EMULATE, INC.
发明人： Kyung-Jin Jang , Hyoungshin Park , Sauveur Jeanty , Janey Ronxhi , Sushma jadalannagari , Geraldine A. Hamilton , Catherine Karalis
摘要： The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.
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