公开(公告)号：US12217883B1

公开(公告)日：2025-02-04

申请号：US18918325

申请日：2024-10-17

Applicant: Sichuan Cancer Hospital

Inventor： Meihua Chen ,  Zengyi Fang ,  Jinyi Lang ,  Pingjin Zou ,  Shixuan Zhao

IPC: G21K1/02 ,  G21K1/04

Abstract: A method for assembling an adjustable collimator for spatially fractionated radiation therapy is disclosed. Penetrating sheets that can transmit rays are stacked to form penetration sections, and the quantity of penetrating sheets is calculated. The thickness of each penetration section corresponds to the width of each radiation area. Shielding sheets that can block rays are stacked to form shielding sections, and the quantity of shielding sheets is calculated, with the thickness of each shielding section corresponding to the spacing between the radiation areas. The penetration sections and shielding sections form a collimation module, with shielding sections on opposite sides. Penetration and shielding sections of different thicknesses are assembled based on the radiation range and the radiation area spacing. Since the thickness of the penetration and shielding sections can be adjusted as needed, it can be applied to spatially fractionated radiation therapy with different requirements, achieving cost reduction.

公开(公告)号：US12083355B1

公开(公告)日：2024-09-10

申请号：US18400131

申请日：2023-12-29

Applicant: Sichuan Cancer Hospital

Inventor： Meihua Chen ,  Pingjin Zou ,  Xinyu Xue ,  Jinyi Lang ,  Lili Xing ,  Rui Lin

IPC: A61N5/06 ,  A61K41/00 ,  C12N5/09 ,  C12N13/00 ,  G01N33/50 ,  H05B45/30

CPC classification number: A61N5/062 ,  A61K41/0071 ,  C12N5/0693 ,  C12N13/00 ,  G01N33/5091 ,  H05B45/30 ,  A61N2005/0652

Abstract: A photodynamic therapy tablet and corresponding preparation method, as well as a construction method and system specifically designed for anti-tumor models, are disclosed. The tablet includes a wireless power supply unit, a circuit unit, micrometer-level LED array, and a flexible transparent biocompatible encapsulation. It can be surgically implanted in close proximity to tumor cells within the human body, enabling precise irradiation of the targeted tumor cells. By harnessing light of a specific wavelength, the tablet facilitates the generation of lipid peroxides, which, in conjunction with a ferroptosis inducer, effectively triggers ferroptotic cell death in tumor cells. The ultrasound wireless self-powering photodynamic therapy tablet is utilized for the treatment of tumor cells through photodynamic therapy (PDT). By combining the ferroptosis inducer with PDT, the present invention effectively addresses the issue of limited efficacy observed when using the ferroptosis inducer alone.