公开(公告)号：US12083355B1

公开(公告)日：2024-09-10

申请号：US18400131

申请日：2023-12-29

申请人： Sichuan Cancer Hospital

发明人： Meihua Chen ,  Pingjin Zou ,  Xinyu Xue ,  Jinyi Lang ,  Lili Xing ,  Rui Lin

IPC分类号： A61N5/06 ,  A61K41/00 ,  C12N5/09 ,  C12N13/00 ,  G01N33/50 ,  H05B45/30

CPC分类号： A61N5/062 ,  A61K41/0071 ,  C12N5/0693 ,  C12N13/00 ,  G01N33/5091 ,  H05B45/30 ,  A61N2005/0652

摘要： A photodynamic therapy tablet and corresponding preparation method, as well as a construction method and system specifically designed for anti-tumor models, are disclosed. The tablet includes a wireless power supply unit, a circuit unit, micrometer-level LED array, and a flexible transparent biocompatible encapsulation. It can be surgically implanted in close proximity to tumor cells within the human body, enabling precise irradiation of the targeted tumor cells. By harnessing light of a specific wavelength, the tablet facilitates the generation of lipid peroxides, which, in conjunction with a ferroptosis inducer, effectively triggers ferroptotic cell death in tumor cells. The ultrasound wireless self-powering photodynamic therapy tablet is utilized for the treatment of tumor cells through photodynamic therapy (PDT). By combining the ferroptosis inducer with PDT, the present invention effectively addresses the issue of limited efficacy observed when using the ferroptosis inducer alone.