公开(公告)号：US12017973B2

公开(公告)日：2024-06-25

申请号：US17253773

申请日：2019-06-11

申请人： BASF SE

发明人： Rodney F. Kilma ,  Dean A. Oester ,  Timothy H. Anderson ,  Mahmud Mustaqim Hussain

IPC分类号： C07C229/36 ,  A01N25/30 ,  A01N37/46 ,  A01N41/06

CPC分类号： C07C229/36 ,  A01N25/30 ,  A01N37/46

摘要： Described herein are alkoxylated compounds of general formula (I) and their use as adjuvant in the treatment of soil and plants. Also described are a composition including at least one biocide and at least one compound of general formula (I), as well as a method for improving the growth and health of plants by treating the crops with the composition including the compounds of general formula (I).

公开(公告)号：US11872217B2

公开(公告)日：2024-01-16

申请号：US16924385

申请日：2020-07-09

申请人： CHEMOCENTRYX, INC.

发明人： Viengkham Malathong ,  Venkat Reddy Mali ,  Darren J. McMurtrie ,  Sreenivas Punna ,  Howard S. Roth ,  Rajinder Singh ,  Ju Yang ,  Penglie Zhang

IPC分类号： A61K31/444 ,  C07D401/12 ,  C07C229/36 ,  C07C219/28 ,  C07C309/24 ,  C07D207/267 ,  A61K31/397 ,  A61K31/4545 ,  A61K31/197 ,  A61K31/137 ,  A61K31/4015 ,  A61K31/4188 ,  C07D487/10

CPC分类号： A61K31/444 ,  A61K31/137 ,  A61K31/197 ,  A61K31/397 ,  A61K31/4015 ,  A61K31/4188 ,  A61K31/4545 ,  C07C219/28 ,  C07C229/36 ,  C07C309/24 ,  C07D207/267 ,  C07D401/12 ,  C07D487/10

摘要： Compounds represented by Formula (I) or (II):




are provided herein, or a pharmaceutically acceptable salt, or a prodrug or bioisostere thereof; wherein R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, R2a′, R2b′, R2c′, R3′, R4′, R5′, R6a′, R6b′, Y, Y′, and the subscripts m and n are as defined herein.

公开(公告)号：US11820790B2

公开(公告)日：2023-11-21

申请号：US16424677

申请日：2019-05-29

申请人： OUT AND OUT CHEMISTRY S.P.R.L.

发明人： Vincent Luc Antoine Tadino ,  Guillaume André René Villeret

IPC分类号： C07H5/02 ,  C01D3/02 ,  C07B59/00 ,  C07C39/40 ,  B01J19/24 ,  B01J41/00 ,  C07C53/18 ,  C07C215/40 ,  C07C229/36 ,  C07D207/46 ,  C07D233/91 ,  C07H19/06

CPC分类号： C07H5/02 ,  B01J19/24 ,  B01J41/00 ,  C01D3/02 ,  C07B59/00 ,  C07C39/40 ,  C07C53/18 ,  C07C215/40 ,  C07C229/36 ,  C07D207/46 ,  C07D233/91 ,  C07H19/06 ,  B01J2219/24 ,  C07C2603/40

摘要： A cassette for performing a plurality of synthesis processes of preparing a radiopharmaceutical in series in a synthesizer, includes: at least one manifold provided with a plurality of valves connectable to and operable by the synthesizer; an anion-exchanger comprising an anionic exchange material; an eluent container comprising an eluent; and a recondition container comprising a reconditioning agent.

公开(公告)号：US20230147021A1

公开(公告)日：2023-05-11

申请号：US17905096

申请日：2021-02-26

申请人： University Public Corporation Osaka ,  Bio-Xcelerator, Inc.

发明人： Hideshi IHARA ,  Shingo KASAMATSU

IPC分类号： C07C229/36 ,  C07C233/17 ,  C07C323/24

CPC分类号： C07C229/36 ,  C07C233/17 ,  C07C323/24

摘要： The present invention is a new tyrosine derivative described below to inhibit hydrolysis of polysulfide.
The new tyrosine derivative formed according to a chemical formula indicated below, wherein one of a-c is “OH” and the rest are “H”;

d is CnH2nα, where α is “H” or a “halogen atom,” the halogen atom is preferably “I,” and n is an integer from 1 to 5; and

e is (NH)x(CO)yCzH2zβ, where x is 1 or 0, y is 1 or 0, z is an integer from 1 to 5, β is “H” or a “halogen atom,”.

公开(公告)号：US11498907B2

公开(公告)日：2022-11-15

申请号：US17015450

申请日：2020-09-09

申请人： KEZAR LIFE SCIENCES

发明人： Henry Johnson ,  Sean Dalziel ,  Dustin McMinn

IPC分类号： C07D303/12 ,  C07D295/13 ,  C07D303/46 ,  C07D295/15 ,  C07C229/36 ,  C07D301/02 ,  C07D303/32

摘要： Disclosed herein are methods for preparing [(2S,3R)-N-[(2S)-3-(cyclopent-1-en-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide (compound “G”): and precursors thereof.

公开(公告)号：US11458158B2

公开(公告)日：2022-10-04

申请号：US16867291

申请日：2020-05-05

申请人： Massachusetts Institute of Technology

发明人： Yizhou Dong ,  Kevin Thomas Love ,  Robert S. Langer ,  Daniel Griffith Anderson ,  Delai Chen ,  Yi Chen ,  Arturo Jose Vegas ,  Akinleye C. Alabi ,  Yunlong Zhang

IPC分类号： A61K31/7105 ,  C07D233/64 ,  C07D403/06 ,  C07D241/08 ,  C07C229/12 ,  C07C229/22 ,  C07C229/26 ,  C07D487/06 ,  C07D207/16 ,  C07D209/20 ,  C07C271/22 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C12N15/88 ,  C12N15/87 ,  C07C229/24 ,  C07C279/14 ,  C07C323/58 ,  C07D209/24 ,  C07D265/32 ,  C07D413/06 ,  C07D487/04 ,  C12Q1/02 ,  G01N33/15 ,  A61K31/711 ,  A61K47/22

摘要： Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

公开(公告)号：US11266686B2

公开(公告)日：2022-03-08

申请号：US15035911

申请日：2014-11-10

申请人： PROCYPRA THERAPEUTICS LLC

发明人： John C. Warner ,  Srinivasa R. Cheruku ,  Anitha Hari ,  James J. Norman

IPC分类号： A61K33/34 ,  A61K51/04 ,  C07C229/36 ,  C07C337/08 ,  G01N33/53 ,  A61K47/54 ,  C07C59/105 ,  C07C59/265 ,  C07C323/58 ,  C07D275/06

摘要： In one embodiment, the present application discloses compounds that are selective neuroactive agents for the treatment of diseases of the central nervous system (CNS). In one aspect, the neuroactive agents are NCDs of metal chelates, including complexes of iron, copper or zinc.

公开(公告)号：US11084813B2

公开(公告)日：2021-08-10

申请号：US15634272

申请日：2017-06-27

申请人： Techfields Pharma Co., Ltd.

发明人： Chongxi Yu ,  Lina Xu

IPC分类号： C07D471/04 ,  C07C271/16 ,  C07C271/22 ,  C07D321/12 ,  C07C219/10 ,  C07C219/14 ,  C07C219/28 ,  C07C229/12 ,  C07C327/30 ,  C07C229/58 ,  C07D455/02 ,  C07C237/06 ,  C07C237/20 ,  C07D207/16 ,  C07K5/083 ,  C07D211/62 ,  C07K5/097 ,  A61K31/137 ,  C07C229/36 ,  A61K31/195 ,  A61K31/198 ,  A61K31/277 ,  C07C317/44 ,  A61K31/197 ,  A61K31/24 ,  A61K31/40 ,  C07C219/06 ,  C07C219/32 ,  C07C237/08 ,  C07C327/36 ,  C07C217/60

摘要： One aspect of the invention provides a composition of novel high penetration compositions (HPC) or a high penetration prodrug (HPP) for treatment of Parkinson's disease. The HPCs/HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPCs/HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

公开(公告)号：US20210094904A1

公开(公告)日：2021-04-01

申请号：US16992199

申请日：2020-08-13

申请人： Teva Pharmaceuticals International GmbH

发明人： Rudolf-Giesbert ALKEN ,  Frank Schneider

IPC分类号： C07C229/36 ,  A61K9/20 ,  A61K9/28 ,  A61K31/165 ,  A61K31/277 ,  A61K31/198 ,  A61K31/216 ,  A61K45/06 ,  C07C227/16

摘要： Herein described are deuterated catecholamine derivatives of the general Formula I wherein, R1 is deuterium, R2, and R3 are independently selected from hydrogen and deuterium and wherein at least one of R2 and R3 has a deuterium enrichment in the range from 0.02 mol % to 100 mol % deuterium, and wherein the deuterium enrichment of R2 and R3 is different from each other and that the difference between the deuterium enrichment of R2 and R3 is at least 5 percentage points, R4 is hydrogen, deuterium, C1 to C6-alkyl or C5 to C6-cycloalkyl, deuterated C1 to C6-alkyl or C5 to C6-cycloalkyl, or a group that is easily hydrolytically or enzymatically cleavable under physiological conditions, as well as their physiologically acceptable salts and their stereoisomers, enantiomers or diastereomers in optically pure form. The compounds can easily be prepared by mixing deuterated and non-deuterated compounds in a predefined ratio. The compounds show anti-Parkinson effect at lower doses and show lower side effects.

公开(公告)号：US10815208B2

公开(公告)日：2020-10-27

申请号：US16303650

申请日：2017-05-23

申请人： Institute of Materia Medica, Chinese Academy of Medical Sciences ,  Tianjin Chase Sun Pharmaceutical Co., LTD

发明人： Zhiqiang Feng ,  Xiaoguang Chen ,  Yang Yang ,  Fangfang Lai

IPC分类号： C07D401/14 ,  C07D295/155 ,  C07C233/36 ,  C07C255/54 ,  C07D405/12 ,  C07C311/05 ,  C07D319/18 ,  C07D207/16 ,  C07C45/61 ,  C07C231/12 ,  A61P35/00 ,  C07C211/29 ,  C07C229/36 ,  C07C235/34 ,  C07D221/00 ,  C07D265/30 ,  C07D407/12 ,  C07C227/12 ,  C07C269/02 ,  C07C271/64 ,  C07D207/08 ,  C07D309/14 ,  C07D319/16 ,  A61K31/36 ,  A61K31/165 ,  A61K31/277 ,  A61K45/06

摘要： Provided is a method for preparing 2-hydroxy-4-(2, 3-disubstituted benzyloxy)-5-substituted benzaldehyde derivative represented by formula (I). The method comprises the following steps: (1) preparing 3-aryl-2-substituted toluene derivative 2 by using 3-iodo-2-substituted toluene derivative 1 and aryl boronic acid 5 or aryl boronate as starting materials; (2) preparing a benzyl halide derivative 3 by using 3-aryl-2-substituted toluene derivative 2 as starting materials; and (3) preparing 4-(2, 3-disubstituted benzyloxy)-2-hydroxy-5-substituted benzaldehyde derivative (I) by using benzyl halide derivative 3 and 2,4-dihydroxy-5-substituted benzaldehyde 6.