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公开(公告)号：US20180118774A1
公开(公告)日：2018-05-03
申请号：US15570771
申请日：2016-05-19
IPC分类号： C07H5/02 , C07B59/00 , B01J19/24 , B01J41/00 , C07D233/91 , C01D3/02 , C07H19/06 , C07C229/36 , C07C39/40 , C07C215/40 , C07C53/18 , C07D207/46
CPC分类号： C07H5/02 , B01J19/24 , B01J41/00 , B01J2219/24 , C01D3/02 , C07B59/00 , C07C39/40 , C07C53/18 , C07C215/40 , C07C229/36 , C07C2603/40 , C07D207/46 , C07D233/91 , C07H19/06
摘要： A method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series includes carrying out a first synthesis run including the steps of: a) providing water containing fluorine-18; b) trapping the fluorine-18 from the water provided in step a) on an anion exchange material; c) eluting the trapped fluorine-18 from the anion exchange material to a reaction vessel of first radiopharmaceutical synthesis cassette; d) preparing a radiopharmaceutical incorporating the eluted fluorine-18 using the first radiopharmaceutical synthesis cassette; where steps a)-d) are repeated in at least one subsequent run using another radiopharmaceutical synthesis cassette; and where the method includes a reconditioning step of the anion exchange material between two consecutive runs. A device for performing this method and a cassette for use in the device are also disclosed.
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2.发明公开公开(公告)号：US20240059724A1
公开(公告)日：2024-02-22
申请号：US18493909
申请日：2023-10-25
IPC分类号： C07H5/02 , C07B59/00 , B01J19/24 , B01J41/00 , C01D3/02 , C07C39/40 , C07C53/18 , C07C215/40 , C07C229/36 , C07D207/46 , C07D233/91 , C07H19/06
CPC分类号： C07H5/02 , C07B59/00 , B01J19/24 , B01J41/00 , C01D3/02 , C07C39/40 , C07C53/18 , C07C215/40 , C07C229/36 , C07D207/46 , C07D233/91 , C07H19/06 , C07C2603/40 , B01J2219/24
摘要： A method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, which method includes carrying out a first synthesis run comprising the steps of: a) providing water containing 18F; b) trapping the 18F from the water provided in step a) on an anion exchange material; c) eluting the trapped 18F from the anion exchange material to a reaction vessel of first radiopharmaceutical synthesis cassette; d) preparing a radiopharmaceutical incorporating the eluted 18F using the first radiopharmaceutical synthesis cassette; where steps a)-d) are repeated in at least one subsequent run using another radiopharmaceutical synthesis cassette; and where the method includes a reconditioning step of treating the anion exchange material with water between two consecutive runs. Other aspects of the invention relate to a device for performing this method, and a cassette for use in the device.
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3.发明申请公开(公告)号：US20190276487A1
公开(公告)日：2019-09-12
申请号：US16424677
申请日：2019-05-29
IPC分类号： C07H5/02 , C07C229/36 , C07D207/46 , C07D233/91 , C07C39/40 , B01J41/00 , C07C215/40 , B01J19/24 , C07B59/00 , C01D3/02 , C07H19/06 , C07C53/18
摘要： A cassette for performing a plurality of synthesis processes of preparing a radiopharmaceutical in series in a synthesizer, includes: at least one manifold provided with a plurality of valves connectable to and operable by the synthesizer; an anion-exchanger comprising an anionic exchange material; an eluent container comprising an eluent; and a recondition container comprising a reconditioning agent.
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公开(公告)号：US11820790B2
公开(公告)日：2023-11-21
申请号：US16424677
申请日：2019-05-29
IPC分类号： C07H5/02 , C01D3/02 , C07B59/00 , C07C39/40 , B01J19/24 , B01J41/00 , C07C53/18 , C07C215/40 , C07C229/36 , C07D207/46 , C07D233/91 , C07H19/06
CPC分类号： C07H5/02 , B01J19/24 , B01J41/00 , C01D3/02 , C07B59/00 , C07C39/40 , C07C53/18 , C07C215/40 , C07C229/36 , C07D207/46 , C07D233/91 , C07H19/06 , B01J2219/24 , C07C2603/40
摘要： A cassette for performing a plurality of synthesis processes of preparing a radiopharmaceutical in series in a synthesizer, includes: at least one manifold provided with a plurality of valves connectable to and operable by the synthesizer; an anion-exchanger comprising an anionic exchange material; an eluent container comprising an eluent; and a recondition container comprising a reconditioning agent.
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公开(公告)号：US10344045B2
公开(公告)日：2019-07-09
申请号：US15570771
申请日：2016-05-19
IPC分类号： C07H5/02 , C07H1/06 , C07B59/00 , C07D207/46 , B01J19/24 , B01J41/00 , C01D3/02 , C07C39/40 , C07C53/18 , C07C215/40 , C07C229/36 , C07D233/91 , C07H19/06
摘要： A method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series includes carrying out a first synthesis run including the steps of: a) providing water containing fluorine-18; b) trapping the fluorine-18 from the water provided in step a) on an anion exchange material; c) eluting the trapped fluorine-18 from the anion exchange material to a reaction vessel of first radiopharmaceutical synthesis cassette; d) preparing a radiopharmaceutical incorporating the eluted fluorine-18 using the first radiopharmaceutical synthesis cassette; where steps a)-d) are repeated in at least one subsequent run using another radiopharmaceutical synthesis cassette; and where the method includes a reconditioning step of the anion exchange material between two consecutive runs. A device for performing this method and a cassette for use in the device are also disclosed.
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