公开(公告)号：US10392405B2

公开(公告)日：2019-08-27

申请号：US16057077

申请日：2018-08-07

Applicant: CHEMOCENTRYX, INC.

Inventor： Viengkham Malathong ,  Jeffrey McMahon ,  Darren J. McMurtrie ,  Sreenivas Punna ,  Howard S. Roth ,  Rajinder Singh ,  Penglie Zhang

IPC: C07D498/08 ,  A61P37/02 ,  A61P31/12 ,  A61P31/04 ,  A61P31/10 ,  A61P35/00

Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I) or (II): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R, R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, R6c, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US11691985B2

公开(公告)日：2023-07-04

申请号：US17338502

申请日：2021-06-03

Applicant: CHEMOCENTRYX, INC.

Inventor： Viengkham Malathong ,  Jeffrey McMahon ,  Darren J. McMurtrie ,  Sreenivas Punna ,  Howard S. Roth ,  Rajinder Singh ,  Penglie Zhang

IPC: C07D498/08 ,  A61P37/02 ,  A61P31/12 ,  A61P31/04 ,  A61P31/10 ,  A61P35/00

CPC classification number: C07D498/08 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P35/00 ,  A61P37/02

Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I) or (II):






including stereoisomers and pharmaceutically acceptable salts thereof, wherein R, R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, R6c, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US11266643B2

公开(公告)日：2022-03-08

申请号：US16874212

申请日：2020-05-14

Applicant: CHEMOCENTRYX, INC.

Inventor： Pingchen Fan ,  Christopher Lange ,  Venkat Reddy Mali ,  Darren J. McMurtrie ,  Viengkham Malathong ,  Sreenivas Punna ,  Rajinder Singh ,  Ju Yang ,  Yibin Zeng ,  Penglie Zhang

IPC: C07D405/12 ,  A61K31/4985 ,  C07D471/04 ,  C07D401/12 ,  A61K31/506 ,  C07D403/12

Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US11708326B2

公开(公告)日：2023-07-25

申请号：US17106309

申请日：2020-11-30

Applicant: CHEMOCENTRYX, INC.

Inventor： Christopher Lange ,  Viengkham Malathong ,  Venkat Reddy Mali ,  Jeffrey McMahon ,  Darren J. McMurtrie ,  Sreenivas Punna ,  Howard S. Roth ,  Rajinder Singh ,  Yu Wang ,  Ju Yang ,  Penglie Zhang

IPC: C07D207/12 ,  A61K45/06 ,  C07D401/12 ,  C07D207/267 ,  C07D211/44 ,  C07D403/12 ,  C07D211/38 ,  C07D451/06 ,  C07D205/12 ,  C07F5/02 ,  C07D405/14 ,  C07D401/14 ,  C07D471/10 ,  C07D211/76 ,  A61P37/02 ,  C07D205/04 ,  C07D213/85 ,  C07D295/088 ,  C07D487/10 ,  C07D405/12 ,  A61K31/40 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/454 ,  A61K31/4545 ,  C07D211/40 ,  C07D211/46

CPC classification number: C07D207/12 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4427 ,  A61K31/454 ,  A61K31/4545 ,  A61K45/06 ,  A61P37/02 ,  C07D205/04 ,  C07D205/12 ,  C07D207/267 ,  C07D211/38 ,  C07D211/40 ,  C07D211/44 ,  C07D211/46 ,  C07D211/76 ,  C07D213/85 ,  C07D295/088 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D451/06 ,  C07D471/10 ,  C07D487/10 ,  C07F5/025

Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I):




including stereoisomers and pharmaceutically acceptable salts thereof, wherein Z, L, R1a, R1b, R1c, R1d, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US11713307B2

公开(公告)日：2023-08-01

申请号：US17071077

申请日：2020-10-15

Applicant: CHEMOCENTRYX, INC.

Inventor： Pingchen Fan ,  Christopher W. Lange ,  Rebecca M. Lui ,  Darren J. McMurtrie ,  Ryan J. Scamp ,  Ju Yang ,  Yibin Zeng ,  Penglie Zhang

IPC: C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D487/10

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D403/14 ,  C07D405/14 ,  C07D487/10

Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I)




including stereoisomers and pharmaceutically acceptable salts thereof, wherein R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US11485708B2

公开(公告)日：2022-11-01

申请号：US16905979

申请日：2020-06-19

Applicant: CHEMOCENTRYX, INC.

Inventor： Viengkham Malathong ,  Pingchen Fan ,  Christopher Lange ,  Venkat Reddy Mali ,  Darren J. McMurtrie ,  Sreenivas Punna ,  Howard S. Roth ,  Rajinder Singh ,  Ju Yang ,  Penglie Zhang

IPC: C07D217/04 ,  A61K45/06 ,  C07D401/12 ,  A61K31/4725 ,  C07C217/58 ,  A61K31/137 ,  C07D211/58 ,  A61K31/4468 ,  A61K31/4545 ,  C07C229/16 ,  A61K31/197 ,  C07D207/06 ,  A61K31/40 ,  C07D319/18 ,  A61K31/357 ,  C07D213/64 ,  A61K31/4402 ,  C07D215/227 ,  A61K31/4704 ,  C07C309/14 ,  A61K31/185 ,  A61K31/472

Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R3a, R4, R5, R6, R7, R8 and the subscript n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US11059834B2

公开(公告)日：2021-07-13

申请号：US16504536

申请日：2019-07-08

Applicant: CHEMOCENTRYX, INC.

Inventor： Viengkham Malathong ,  Jeffrey McMahon ,  Darren J. McMurtrie ,  Sreenivas Punna ,  Howard S. Roth ,  Rajinder Singh ,  Penglie Zhang

IPC: C07D498/08 ,  A61P37/02 ,  A61P31/12 ,  A61P31/04 ,  A61P31/10 ,  A61P35/00

Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I) or (II): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R, R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, R6c, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US11872217B2

公开(公告)日：2024-01-16

申请号：US16924385

申请日：2020-07-09

Applicant: CHEMOCENTRYX, INC.

Inventor： Viengkham Malathong ,  Venkat Reddy Mali ,  Darren J. McMurtrie ,  Sreenivas Punna ,  Howard S. Roth ,  Rajinder Singh ,  Ju Yang ,  Penglie Zhang

IPC: A61K31/444 ,  C07D401/12 ,  C07C229/36 ,  C07C219/28 ,  C07C309/24 ,  C07D207/267 ,  A61K31/397 ,  A61K31/4545 ,  A61K31/197 ,  A61K31/137 ,  A61K31/4015 ,  A61K31/4188 ,  C07D487/10

CPC classification number: A61K31/444 ,  A61K31/137 ,  A61K31/197 ,  A61K31/397 ,  A61K31/4015 ,  A61K31/4188 ,  A61K31/4545 ,  C07C219/28 ,  C07C229/36 ,  C07C309/24 ,  C07D207/267 ,  C07D401/12 ,  C07D487/10

Abstract: Compounds represented by Formula (I) or (II):




are provided herein, or a pharmaceutically acceptable salt, or a prodrug or bioisostere thereof; wherein R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, R2a′, R2b′, R2c′, R3′, R4′, R5′, R6a′, R6b′, Y, Y′, and the subscripts m and n are as defined herein.

公开(公告)号：US11866429B2

公开(公告)日：2024-01-09

申请号：US17071056

申请日：2020-10-15

Applicant: CHEMOCENTRYX, INC.

Inventor： Pingchen Fan ,  Christopher W. Lange ,  Rebecca M. Lui ,  Darren J. McMurtrie ,  Ryan J. Scamp ,  Ju Yang ,  Yibin Zeng ,  Penglie Zhang

IPC: C07D471/04 ,  A61K45/06

CPC classification number: C07D471/04 ,  A61K45/06

Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I)




including stereoisomers and pharmaceutically acceptable salts thereof, wherein R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US11793771B2

公开(公告)日：2023-10-24

申请号：US17838400

申请日：2022-06-13

Applicant: CHEMOCENTRYX, INC.

Inventor： Christopher Lange ,  Viengkham Malathong ,  Darren J. McMurtrie ,  Sreenivas Punna ,  Rajinder Singh ,  Ju Yang ,  Penglie Zhang

IPC: A61K31/085 ,  C07D211/40 ,  A61P35/00 ,  C07C215/12 ,  C07F5/02 ,  C07D401/14 ,  C07D213/30 ,  C07D405/12 ,  C07C229/22 ,  C07D319/18 ,  C07D417/12 ,  A61K45/06 ,  C07C235/42 ,  C07C235/20 ,  C07D239/42 ,  C07C255/54 ,  C07D213/61 ,  C07D413/12 ,  C07D205/04 ,  A61P31/00 ,  C07D237/08 ,  C07D401/12 ,  C07D213/85 ,  C07D239/30 ,  C07D405/14 ,  C07D401/04 ,  C07D409/12 ,  C07D213/80 ,  A61P29/00 ,  C07C317/22 ,  C07F9/58 ,  A61K31/015 ,  A61K31/03 ,  A61K31/277 ,  A61K38/00 ,  C07C43/168 ,  A61K31/36 ,  A61K31/44 ,  A61K31/505 ,  A61K47/34

CPC classification number: A61K31/085 ,  A61K31/015 ,  A61K31/03 ,  A61K31/277 ,  A61K38/00 ,  A61K45/06 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  C07C43/168 ,  C07C215/12 ,  C07C229/22 ,  C07C235/20 ,  C07C235/42 ,  C07C255/54 ,  C07C317/22 ,  C07D205/04 ,  C07D211/40 ,  C07D213/30 ,  C07D213/61 ,  C07D213/80 ,  C07D213/85 ,  C07D237/08 ,  C07D239/30 ,  C07D239/42 ,  C07D319/18 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07F5/025 ,  C07F9/58 ,  A61K31/36 ,  A61K31/44 ,  A61K31/505 ,  A61K47/34 ,  C07C2601/02 ,  C07C2602/08 ,  Y02A50/30

Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (II):






including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2a, R2b, R2c, R3, R4, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.