公开(公告)号：US11713307B2

公开(公告)日：2023-08-01

申请号：US17071077

申请日：2020-10-15

Applicant: CHEMOCENTRYX, INC.

Inventor： Pingchen Fan ,  Christopher W. Lange ,  Rebecca M. Lui ,  Darren J. McMurtrie ,  Ryan J. Scamp ,  Ju Yang ,  Yibin Zeng ,  Penglie Zhang

IPC: C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D487/10

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D403/14 ,  C07D405/14 ,  C07D487/10

Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I)




including stereoisomers and pharmaceutically acceptable salts thereof, wherein R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US11866429B2

公开(公告)日：2024-01-09

申请号：US17071056

申请日：2020-10-15

Applicant: CHEMOCENTRYX, INC.

Inventor： Pingchen Fan ,  Christopher W. Lange ,  Rebecca M. Lui ,  Darren J. McMurtrie ,  Ryan J. Scamp ,  Ju Yang ,  Yibin Zeng ,  Penglie Zhang

IPC: C07D471/04 ,  A61K45/06

CPC classification number: C07D471/04 ,  A61K45/06

Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I)




including stereoisomers and pharmaceutically acceptable salts thereof, wherein R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.