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    HIGH PENETRATION PRODRUG COMPOSITIONS OF ANTIMICROBIALS AND ANTIMICROBIAL-RELATED COMPOUNDS
    3.
    发明申请
    HIGH PENETRATION PRODRUG COMPOSITIONS OF ANTIMICROBIALS AND ANTIMICROBIAL-RELATED COMPOUNDS 有权

    公开(公告)号：US20230130980A1

    公开(公告)日：2023-04-27

    申请号：US18051060

    申请日：2022-10-31

    申请人： TECHFIELDS PHARMA CO., LTD.

    发明人： Chongxi Yu ,  Lina Xu ,  Yuhua Chen ,  Binbing Yan ,  Shiqian Tu

    IPC分类号： C07D499/21

    摘要： The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of antimicrobials and antimicrobial-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPCs/HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPCs/HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

    High penetration prodrug compositions of mustards and mustard-related compounds
    4.
    发明授权
    High penetration prodrug compositions of mustards and mustard-related compounds 有权

    公开(公告)号：US11479527B2

    公开(公告)日：2022-10-25

    申请号：US16209744

    申请日：2018-12-04

    申请人： Techfields Pharma Co., Ltd.

    发明人： Chongxi Yu ,  Lina Xu

    IPC分类号： C07C233/47 ,  C07C229/42 ,  C07F9/24

    摘要： The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of mustards and mustard-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

    High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds
    7.
    发明授权
    High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds 有权

    公开(公告)号：US11485744B2

    公开(公告)日：2022-11-01

    申请号：US15947983

    申请日：2018-04-09

    申请人： Techfields Pharma Co., Ltd.

    发明人： Chongxi Yu ,  Lina Xu ,  Yuhua Chen ,  Binbing Yan ,  Shiqian Tu

    IPC分类号： C07D499/21

    摘要： The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of antimicrobials and antimicrobial-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPCs/HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPCs/HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

    HIGH PENETRATION COMPOSITION AND USES THEREOF
    8.
    发明申请
    HIGH PENETRATION COMPOSITION AND USES THEREOF 有权

    公开(公告)号：US20220096370A1

    公开(公告)日：2022-03-31

    申请号：US17493321

    申请日：2021-10-04

    申请人： TECHFIELDS PHARMA CO., LTD

    发明人： Chongxi Yu ,  Lina Xu

    IPC分类号： A61K9/00 ,  C07C233/25 ,  A61K31/22 ,  C07C231/12 ,  A61K47/54 ,  A61K9/70 ,  A61K31/167 ,  A61K31/612

    摘要： The present invention relates to compositions and uses of novel high penetration compositions or high penetration prodrugs (HPP), in particular HPPs for 4-aminophenol derivatives, which are capable of crossing biological barriers with high penetration efficiency. The HPPs herein are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, due to the ability of penetrating biological barriers, the HPPs herein are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs herein can be administered to a subject through various administration routes. For example, the HPPs can be locally delivered to an action site of a condition with a high concentration due to their ability of penetrating biological barriers and thus obviate the need for a systematic administration. For another example, the HPPs herein can be systematically administer to a biological subject and enter the general circulation with a faster rate.