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29 条记录 (耗时 0.023 秒)

    HIGH PENETRATION COMPOSITIONS AND USES THEREOF
    1.
    发明申请
    HIGH PENETRATION COMPOSITIONS AND USES THEREOF 有权

    公开(公告)号：US20210353579A1

    公开(公告)日：2021-11-18

    申请号：US16421735

    申请日：2019-05-24

    申请人： Techfields Pharma Co., Ltd.

    发明人： Chongxi Yu ,  Lina XU

    IPC分类号： A61K31/216 ,  A61K9/00 ,  A61K9/70 ,  A61K31/24 ,  A61L15/44 ,  A61K47/54

    摘要： The present invention relates to compositions and uses of novel high penetration compositions or high penetration prodrugs (HPP), in particular HPPs for non-steroidal anti-inflammatory agents (NSAIAs), which are capable of crossing biological barriers with high penetration efficiency. The HPPs herein are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, due to the ability of penetrating biological barriers, the HPPs herein are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs herein can be administered to a subject through various administration routes. For example, the HPPs can be locally delivered to an action site of a condition with a high concentration due to their ability of penetrating biological barriers and thus obviate the need for a systematic administration. For another example, the HPPs herein can be systematically administer to a biological subject and enter the general circulation with a faster rate.

    High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds
    6.
    发明授权
    High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds 有权

    公开(公告)号：US11485744B2

    公开(公告)日：2022-11-01

    申请号：US15947983

    申请日：2018-04-09

    申请人： Techfields Pharma Co., Ltd.

    发明人： Chongxi Yu ,  Lina Xu ,  Yuhua Chen ,  Binbing Yan ,  Shiqian Tu

    IPC分类号： C07D499/21

    摘要： The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of antimicrobials and antimicrobial-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPCs/HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPCs/HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

    HIGH PENETRATION COMPOSITION AND USES THEREOF
    7.
    发明申请
    HIGH PENETRATION COMPOSITION AND USES THEREOF 有权

    公开(公告)号：US20220096370A1

    公开(公告)日：2022-03-31

    申请号：US17493321

    申请日：2021-10-04

    申请人： TECHFIELDS PHARMA CO., LTD

    发明人： Chongxi Yu ,  Lina Xu

    IPC分类号： A61K9/00 ,  C07C233/25 ,  A61K31/22 ,  C07C231/12 ,  A61K47/54 ,  A61K9/70 ,  A61K31/167 ,  A61K31/612

    摘要： The present invention relates to compositions and uses of novel high penetration compositions or high penetration prodrugs (HPP), in particular HPPs for 4-aminophenol derivatives, which are capable of crossing biological barriers with high penetration efficiency. The HPPs herein are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, due to the ability of penetrating biological barriers, the HPPs herein are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs herein can be administered to a subject through various administration routes. For example, the HPPs can be locally delivered to an action site of a condition with a high concentration due to their ability of penetrating biological barriers and thus obviate the need for a systematic administration. For another example, the HPPs herein can be systematically administer to a biological subject and enter the general circulation with a faster rate.

    High penetration prodrug compositions of 1H-imidazo[4,5-c]quinolin-4-amines and 1H-imidazo[4,5-c]quinolin-4-amine-related compounds and uses thereof
    8.
    发明授权
    High penetration prodrug compositions of 1H-imidazo[4,5-c]quinolin-4-amines and 1H-imidazo[4,5-c]quinolin-4-amine-related compounds and uses thereof 有权
    1H-咪唑并[4,5-c]喹啉-4-胺和1H-咪唑并[4,5-c]喹啉-4-胺相关化合物的高渗透前药组合物及其用途

    公开(公告)号：US09567329B2

    公开(公告)日：2017-02-14

    申请号：US13732256

    申请日：2012-12-31

    申请人： Techfields Pharma Co., Ltd

    发明人： Chongxi Yu

    IPC分类号： C07D471/00 ,  A61K31/44 ,  A61K31/4745 ,  C07D471/04 ,  A61K9/00

    CPC分类号： C07D471/04 ,  A61K9/0014 ,  A61K31/44 ,  A61K31/4745

    摘要： The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of 1H-imidazo[4,5-c]quinolin-4-amines and 1H-imidazo[4,5-c]quinolin-4-amine-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

    摘要翻译： 本发明提供了1H-咪唑并[4,5-c]喹啉-4-胺和1H-咪唑并[4,5-c]喹啉-4-胺的新型高渗透组合物（HPC）或高渗透前药（HPP） 胺相关化合物，其能够穿过具有高穿透效率的生物屏障。 HPP在穿过生物屏障后能够转化为亲本活性药物或药物代谢物，因此可以对母体药物或代谢物可以进行的处理。 此外，HPP能够达到母体药物可能无法进入或在目标区域提供足够浓度的区域，从而进行新的治疗。 HPP可以通过各种施用途径施用于受试者，例如局部递送至具有高浓度或系统地施用于生物受试者的病症的作用部位并以更快的速率进入总体循环。