公开(公告)号：US11661391B2

公开(公告)日：2023-05-30

申请号：US17481753

申请日：2021-09-22

Applicant: INDIAN INSTITUTE OF TECHNOLOGY BOMBAY ,  HARMONY ORGANICS PRIVATE LIMITED

Inventor： Sumit Kamal ,  Rakesh Dhillon ,  Sanjay Mahajani ,  Rahul Nabar ,  Ravi Nangia

IPC: C07C45/72 ,  B01J31/00 ,  C07C45/61 ,  B01J8/06 ,  B01J47/02 ,  B01J39/19

CPC classification number: C07C45/61 ,  B01J8/067 ,  B01J39/19 ,  B01J47/02 ,  B01J2208/00407

Abstract: Provided herein is a method for producing methyl pentenone (MPO) in high yield in a continuous mode in a fixed bed reactor having a plurality of sidewall injecting ports by reacting excess methyl ethyl ketone (MEK) with acetaldehyde in presence of a cation exchange resin catalyst, wherein the acetaldehyde is injected from the plurality of sidewall injecting ports of the reactor. The method is also effective in reducing the complete consumption of the catalyst during the course of the reaction.

公开(公告)号：US20230024552A1

公开(公告)日：2023-01-26

申请号：US17785081

申请日：2020-12-16

Applicant: BASF SE

Inventor： Ralf PELZER ,  Florian GARLICHS ,  Silke WEYLAND ,  Jens WITTENBERG ,  Wolfgang SIEGEL

IPC: C11B9/00 ,  C07C47/21 ,  C07C45/61

Abstract: The present invention relates to 2,4-diethylocta-2,6-dienal and a method of preparing same, to the use of 2,4-diethylocta-2,6-dienal as aroma chemical; to the use of 2,4-diethylocta-2,6-dienal for preparing an aroma chemical composition or for modifying the aroma character of an aroma chemical composition; to an aroma chemical composition containing 2,4-diethylocta-2,6-dienal; and to a method of preparing an aromatized composition or for modifying the aroma character of an aromatized composition.

公开(公告)号：US20230016922A1

公开(公告)日：2023-01-19

申请号：US17784537

申请日：2020-12-01

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

Inventor： Wei Wang

IPC: C07B59/00 ,  C07C45/61 ,  C07C47/542 ,  C07C47/546 ,  C07D295/10 ,  C07D209/08 ,  C07D209/12 ,  C07D207/16 ,  C07D333/56 ,  C07C47/228 ,  C07D317/54 ,  C07F7/18 ,  C07C47/453 ,  C07D211/32 ,  C07C229/16 ,  C07C59/74 ,  C07C49/86 ,  C07C255/60 ,  C07D213/48 ,  C07D307/46 ,  C07D239/52 ,  C07D333/22 ,  C07J9/00 ,  C07D493/04

Abstract: Described are methods for preparing a deuterated aldehyde using with a photocatalyst and a hydrogen atom transfer agent in a H2O free solvent comprising D2O and an organic solvent under an inert gas. The methods may be used to convert a wide variety of aldehydes (e.g., aryl, alkyl, or alkenyl aldehydes) to C-1 deuterated aldehydes under mild reaction conditions.

公开(公告)号：USRE49222E1

公开(公告)日：2022-09-27

申请号：US16668703

申请日：2019-10-30

Applicant: DAIKIN INDUSTRIES, LTD. ,  OSAKA UNIVERSITY

Inventor： Kenji Adachi ,  Takashi Shibanuma ,  Takabumi Nagai ,  Sensuke Ogoshi ,  Masato Ohashi

IPC: C07F1/08 ,  C07B37/04 ,  C07C17/263 ,  C07C25/13 ,  C07C37/18 ,  C07C39/367 ,  C07C41/30 ,  C07C43/225 ,  C07C45/45 ,  C07C45/61 ,  C07C45/68 ,  C07C47/55 ,  C07C49/233 ,  C07C49/235 ,  C07C49/84 ,  C07C67/00 ,  C07C67/30 ,  C07C67/343 ,  C07C69/65 ,  C07C69/76 ,  C07C69/78 ,  C07C209/68 ,  C07C253/30 ,  C07C255/50 ,  C07C381/00 ,  C07D213/26 ,  C07D307/87 ,  C07D333/12 ,  C07F5/02 ,  C07F5/04 ,  C07F7/08 ,  C07F7/12 ,  C07F7/18

Abstract: An object of the present invention is to enable the synthesis of various fluorine-containing compounds having an organic group at both terminals of their tetrafluoroethylene structure (—CF2—CF2—). The present invention provides a fluorine-containing complex compound including a fluorine-containing organic metal compound represented by formula (1a): R1—CF2—CF2-M1  (1a) wherein M1 is a metal selected from the group consisting of copper, zinc, nickel, iron, cobalt, and tin; and R1 represents an organic group, and at least one ligand selected from the group consisting of pyridine ring-containing compounds and phosphines.

公开(公告)号：US20180118646A1

公开(公告)日：2018-05-03

申请号：US15797568

申请日：2017-10-30

Applicant: TOSOH CORPORATION ,  KYOTO UNIVERSITY

Inventor： Hisao EGUCHI ,  Takanori MIYAZAKI ,  Yoshiaki NAKAO

IPC: C07C41/30 ,  C07C1/32 ,  C07C17/263 ,  C07C67/28 ,  C07D213/16 ,  C07D295/033 ,  C07C45/61 ,  C07C303/30 ,  C07D213/64 ,  C07D215/06 ,  C07D217/04 ,  C07D409/04

CPC classification number: C07C41/30 ,  C07B37/04 ,  C07C1/321 ,  C07C1/323 ,  C07C17/263 ,  C07C41/18 ,  C07C45/45 ,  C07C45/49 ,  C07C45/59 ,  C07C45/61 ,  C07C67/28 ,  C07C67/343 ,  C07C303/30 ,  C07C315/04 ,  C07C2527/12 ,  C07C2603/24 ,  C07D213/16 ,  C07D213/64 ,  C07D215/06 ,  C07D217/04 ,  C07D295/033 ,  C07D409/04 ,  C07C43/205 ,  C07C43/225 ,  C07C15/14 ,  C07C15/24 ,  C07C15/28 ,  C07C22/08 ,  C07C25/13 ,  C07C69/78 ,  C07C69/94 ,  C07C47/575 ,  C07C49/78 ,  C07C317/14

Abstract: In a cross coupling reaction, in a case where a halogen atom is selected as the leaving group of the raw material compound, a harmful halogen waste forms as a by-product after the reaction, and disposal of the waste liquid is complicated and environmental burden is high. In a carbon-hydrogen activation cross coupling reaction which requires no halogen atom as the leaving group, although no halogen waste forms as a by-product, the reaction substrate is considerably restricted, and the reaction remains a limited molecular construction method.A method for producing an aromatic compound, which comprises subjecting an aromatic nitro compound and a boronic acid compound to a cross coupling reaction in the presence of a metal catalyst.

公开(公告)号：US09845302B2

公开(公告)日：2017-12-19

申请号：US14768883

申请日：2014-02-19

Applicant: Council of Scientific and Industrial Research

Inventor： Dumbala Srinivasa Reddy ,  Kishor Laxman Handore

IPC: C07D307/94 ,  C07D493/10 ,  C07D301/00 ,  C07C67/347 ,  C07C45/61 ,  C07C45/27 ,  C07C45/67 ,  A61K31/34 ,  A61K31/343

CPC classification number: C07D307/94 ,  C07C45/27 ,  C07C45/61 ,  C07C45/67 ,  C07C67/347 ,  C07D301/00 ,  C07D493/10

Abstract: The invention disclosed herein relates to novel Peribysin E analogs of general formula-I. Further the invention provides simple, economical and short synthesis of Peribysin E and its analogs of Formula I, in good yield and purity leading to the identification of more potent cell adhesion inhibitors.

公开(公告)号：US09765007B2

公开(公告)日：2017-09-19

申请号：US14917114

申请日：2014-09-18

Applicant: Rohm and Haas Company

Inventor： Stacy W. Hoy, IV ,  Dmitri A. Kraptchetov ,  Mark A. Silvano

IPC: C07C67/00 ,  C07C45/83 ,  C07C45/65 ,  C07C45/80 ,  C07C45/82 ,  C07C45/50 ,  C07C45/61 ,  C07C67/44

CPC classification number: C07C45/83 ,  C07C45/505 ,  C07C45/61 ,  C07C45/65 ,  C07C45/80 ,  C07C45/82 ,  C07C67/44 ,  C07C47/22

Abstract: A process for preparing dry methacrolein, and a process for producing methyl methacrylate are disclosed.

公开(公告)号：US09676622B2

公开(公告)日：2017-06-13

申请号：US14459673

申请日：2014-08-14

Applicant: Shiono Chemical Co., Ltd.

Inventor： Hironao Sajiki ,  Yasunari Monguchi ,  Yoshinari Sawama ,  Shinichi Kondo

IPC: C01B3/10 ,  C01B3/08 ,  C01B4/00 ,  C07B31/00 ,  C07B35/02 ,  C07B35/06 ,  C07B59/00 ,  C07C1/26 ,  C07C5/09 ,  C07C5/10 ,  C07C29/143 ,  C07C29/17 ,  C07C41/20 ,  C07C41/24 ,  C07C41/26 ,  C07C45/61 ,  C07C209/36 ,  C07C213/02 ,  C07C221/00

CPC classification number: C01B3/10 ,  C01B3/08 ,  C01B4/00 ,  C01B2203/0277 ,  C01B2203/1047 ,  C01B2203/1064 ,  C07B31/00 ,  C07B35/02 ,  C07B35/06 ,  C07B59/00 ,  C07B2200/05 ,  C07C1/26 ,  C07C5/09 ,  C07C5/10 ,  C07C29/143 ,  C07C29/17 ,  C07C41/20 ,  C07C41/24 ,  C07C41/26 ,  C07C45/61 ,  C07C209/36 ,  C07C213/02 ,  C07C221/00 ,  C07C2523/745 ,  C07C2601/14 ,  Y02E60/364 ,  C07C215/68 ,  C07C211/58 ,  C07C217/84 ,  C07C225/22 ,  C07C33/20 ,  C07C43/2055 ,  C07C33/22 ,  C07C43/205 ,  C07C43/23 ,  C07C49/807 ,  C07C15/18 ,  C07C13/28 ,  C07C15/24 ,  C07C15/52 ,  C07C9/15

Abstract: An object is to provide a process for providing hydrogen or heavy hydrogens conveniently without the necessity of large-scale equipment and a process capable of performing hydrogenation (protiation, deuteration or tritiation) reaction conveniently without the use of an expensive reagent and a special catalyst. The production process includes a process for producing hydrogen or heavy hydrogens, containing subjecting water or heavy water to mechanochemical reaction in the presence of a catalyst metal, and a process for producing a hydrogenated (protiated, deuterated or tritiated) organic compound, containing subjecting an organic compound and water or heavy water to mechanochemical reaction in the presence of a catalyst metal.

公开(公告)号：US09617231B2

公开(公告)日：2017-04-11

申请号：US14941800

申请日：2015-11-16

Applicant: H. Lundbeck A/S

Inventor： Morten Jorgensen ,  Peter Hongaard Andersen ,  Klaus Gjervig Jensen

IPC: C07D295/073 ,  C07B59/00 ,  C07D241/04 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/496 ,  A61K31/519 ,  A61K31/551 ,  A61K31/554 ,  C07C45/61 ,  C07C45/67

CPC classification number: C07D295/073 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/496 ,  A61K31/519 ,  A61K31/551 ,  A61K31/554 ,  C07B59/002 ,  C07B2200/05 ,  C07C45/61 ,  C07C45/67 ,  C07D241/04

Abstract: The present invention relates to deuterated 1-piperazino-3-phenyl-indanes and salts thereof with activity at dopamine receptors D1 and D2 as well as the 5HT2 receptors in the central nervous system, to medicaments comprising such compounds as active ingredients, to the use of such compounds in the treatment of diseases in the central nervous system, and to methods of treatment comprising administration of such compounds.

公开(公告)号：US20160318839A1

公开(公告)日：2016-11-03

申请号：US15105047

申请日：2014-12-14

Applicant: RHODIA OPERATIONS

Inventor： Laurent GAREL ,  Stephanie NORMAND ,  Stephanie FOUCHER ,  Dominique HORBEZ ,  Morad ASSAM

IPC: C07C51/47 ,  C07C45/61 ,  C07C45/29 ,  B01D15/08 ,  C07C51/41

CPC classification number: C07C51/47 ,  B01D15/08 ,  C07C45/29 ,  C07C45/512 ,  C07C45/61 ,  C07C51/367 ,  C07C51/41 ,  C07C59/52 ,  C07C47/58

Abstract: The invention describes a method for separating a mandelic compound in salified form from an aqueous reaction medium resulting from the condensation reaction of a hydroxylated aromatic compound with glyoxylic acid in a basic medium, said method comprising a) decanting said reaction medium in such a way as to recover an organic phase formed from the excess of said aromatic compound and an aqueous phase formed from said mandelic compound and a quantity of the excess of said aromatic compound and b) bringing said aqueous phase into contact with an adsorbent support, resulting in the selective adsorption of said aromatic compound and the recovery of an aqueous flow comprising said mandelic compound in salified form, which is subjected to an oxidation step before being converted into hydroxyaromatic aldehyde by electrodialysis.

Abstract translation: 本发明描述了一种从碱性介质中羟基化芳族化合物与乙醛酸的缩合反应产生的水性反应介质中分离成盐形态的扁桃酸化合物的方法，所述方法包括：a）将所述反应介质以如 回收由过量的所述芳族化合物形成的有机相和由所述扁桃酸化合物形成的水相和一定量的所述芳族化合物，以及b）使所述水相与吸附剂载体接触，导致选择性 所述芳香族化合物的吸附和含有所述扁桃酸化合物的盐水形式的水溶液的回收，所述盐水经过氧化步骤，然后通过电渗析转化为羟基芳族醛。