公开(公告)号：US11891349B2

公开(公告)日：2024-02-06

申请号：US16967898

申请日：2019-02-13

申请人： CMBlu Energy AG

发明人： Jan Hartwig ,  Nastaran Krawczyk ,  Alexander Möller ,  Peter Geigle ,  Evgeny Larionov

IPC分类号： C07C215/50 ,  C07C41/26 ,  C07C45/29 ,  H01M8/08 ,  C07C45/41 ,  C07C45/55 ,  C07C45/67 ,  C07C45/71 ,  C07C51/235 ,  C07C51/60 ,  C07C213/02 ,  C07C303/04 ,  C07C309/44 ,  C07G1/00 ,  H01M8/18

CPC分类号： C07C215/50 ,  C07C41/26 ,  C07C45/29 ,  C07C45/41 ,  C07C45/55 ,  C07C45/673 ,  C07C45/71 ,  C07C51/235 ,  C07C51/60 ,  C07C213/02 ,  C07C303/04 ,  C07C309/44 ,  C07G1/00 ,  H01M8/08 ,  H01M8/188 ,  C07C2603/24 ,  H01M2300/0002

摘要： The present invention relates to novel lignin-derived compounds and compositions comprising the same and their use as redox flow battery electrolytes. The invention further provides a method for preparing said compounds and compositions as well as a redox flow battery comprising said compounds and compositions. Additionally, an assembly for carrying out the inventive method is provided.

公开(公告)号：US11577233B2

公开(公告)日：2023-02-14

申请号：US17673220

申请日：2022-02-16

申请人： UNIVERSITA DEGLI STUDI DI UDINE ,  INNOVATION FACTORY S.R.L.

发明人： Walter Baratta ,  Salvatore Baldino ,  Steven Giboulot

IPC分类号： B01J31/24 ,  C07B41/02 ,  C07F15/00 ,  C07C29/143 ,  C07C29/145 ,  C07C41/26 ,  C07C201/12 ,  C07C29/14 ,  B01J31/18

摘要： The invention relates to monocarbonyl complexes of ruthenium and osmium with bi- and tridentate nitrogen and phosphine ligands. The invention relates to methods for preparing these complexes and the use of these complexes, isolated or prepared in situ, as catalysts for reduction reactions of ketones and aldehydes both via transfer hydrogenation or hydrogenation with hydrogen.

公开(公告)号：US20210061744A1

公开(公告)日：2021-03-04

申请号：US17010241

申请日：2020-09-02

申请人： Shin-Etsu Chemical Co., Ltd.

发明人： Yuki Miyake ,  Takeshi Kinsho ,  Ryo Komatsu

IPC分类号： C07C41/26 ,  C07C45/51

摘要： A process for preparing a dienynal compound of the following general formula (2): CH2═CHC≡CCH═CH(CH2)nCHO (2), wherein n represents an integer of 0 to 11, the process comprising a step of hydrolyzing a dialkoxyalkadienyne compound of the following general formula (1): CH2═CHC≡CCH═CH(CH2)nCH(OR1)(OR2) (1) wherein R1 and R2 represent, independently of each other, a monovalent hydrocarbon group having 1 to 15 carbon atoms, preferably 1 to 8, mere preferably 1 to 4, or R1 and R2 may be bonded to each other to form a divalent hydrocarbon group, R1-R2, having from 2 to 10 carbon atoms, and n represents an integer of 0 to 11, to obtain the dienynal compound (2).

公开(公告)号：US10752575B2

公开(公告)日：2020-08-25

申请号：US16321299

申请日：2017-07-28

申请人： MITSUBISHI TANABE PHARMA CORPORATION

发明人： Makoto Kawano ,  Takashi Naka ,  Mitsuharu Nakamura ,  Hisao Takayanagi

IPC分类号： C07C41/26 ,  C07C213/02 ,  C07C43/23 ,  C07C217/64

摘要： The present invention relates to a production method of 4-alkoxy-3-trifluoromethylbenzyl alcohol at a high conversion ratio, which can strictly suppress production of a byproduct by using DIBAL as a reducing agent.

公开(公告)号：US20200207692A1

公开(公告)日：2020-07-02

申请号：US16621655

申请日：2018-06-12

申请人： BASF Agro B.V.

发明人： Joachim GEBHARDT ,  Jan Klaas LOHMANN ,  David ANDERSON ,  Michael RACK ,  Roland GOETZ

IPC分类号： C07C41/26 ,  C07D249/08

摘要： The present invention relates to a process for the preparation of the compounds of formula II using a lanthanoid salt.

公开(公告)号：US20200170907A1

公开(公告)日：2020-06-04

申请号：US16780018

申请日：2020-02-03

申请人： Unigen, Inc.

发明人： Qi Jia ,  Ji-Fu Zhao

IPC分类号： A61K8/34 ,  A61K8/49 ,  C07C41/32 ,  C07C41/26 ,  A61Q19/02 ,  C07C43/23 ,  C07D321/12 ,  C07C215/74 ,  C07C49/835 ,  C07C45/67 ,  C07C39/367 ,  C07C39/15 ,  A61K31/704 ,  A61K31/40 ,  A61K31/357 ,  A61K31/09 ,  A61K31/085 ,  A61K31/05 ,  A61K31/015 ,  A61K8/97 ,  A61K8/31

摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

公开(公告)号：US10533008B2

公开(公告)日：2020-01-14

申请号：US16083128

申请日：2017-03-01

申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, IONC.

发明人： Chung K. Chu ,  Varughese Alexander Mulamootttil ,  Ram C. Mishra ,  Uma Sharan Singh

IPC分类号： C07D473/34 ,  C07D317/44 ,  C07C41/26 ,  C07C41/30 ,  C07D473/18 ,  C07D473/26 ,  C07D473/40 ,  C07F9/6561 ,  C07C41/28 ,  A61P31/20 ,  C07C43/196

摘要： The invention provides a new convergent approach for the synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA) and 2′-fluoro-6′-methylene-carbocyclic guanosine (FMCG) from a readily available starting material in eight steps. An efficient and practical methodology for stereospecific preparation of a versatile carbocyclic key intermediate, (1S,3R,4R)-3-tert-butoxy-4-(tert-butoxymethyl)-2-fluoro-5-methylenecyclopentanol (compound 8 of scheme 1A or a) in only six (6) steps is also provided. Prodrugs of these compounds are also prepared.

公开(公告)号：US10442792B2

公开(公告)日：2019-10-15

申请号：US16132997

申请日：2018-09-17

申请人： AbbVie Inc.

发明人： Russell D. Cink ,  Kirill A. Lukin ,  Marvin R. Leanna ,  Matthew J. Pelc ,  Timothy B. Towne ,  Dennie S. Welch ,  Kenneth M. Engstrom ,  Matthew M. Ravn ,  Richard D. Bishop ,  Gang Zhao ,  Jianzhang Mei ,  Jeff M. Kallemeyn ,  David R. Hill ,  Michael J. Abrahamson ,  Westin H. Morrill

IPC分类号： C07D403/12 ,  C07D405/14 ,  C07D241/44 ,  C07D405/06 ,  C07C271/34 ,  C07C43/196 ,  C07D487/04 ,  C07C269/06 ,  C07C41/26 ,  C07C67/08 ,  C07C68/02 ,  C12P1/00 ,  C07C211/35 ,  C12P41/00 ,  C07C69/74 ,  C07C269/04

摘要： The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.

公开(公告)号：US10384994B2

公开(公告)日：2019-08-20

申请号：US15680258

申请日：2017-08-18

申请人： Purdue Research Foundation

发明人： P Veeraraghavan Ramachandran ,  Ameya Sanjay Kulkarni ,  Michael Patrick Drolet

IPC分类号： C07C29/48 ,  C07F5/02 ,  C07C31/125 ,  C07C31/137 ,  C07C33/20 ,  C07C43/13 ,  C07C41/26 ,  C07C31/36 ,  C07F7/18 ,  C07C31/135 ,  C07C31/27 ,  C07C29/03

摘要： The present disclosure generally relates to a process for hydroboration of an alkene or alkyne using ammonia borane (AB). In particular, the present invention relates to hydroboration of an alkene or alkyne in the presence of air or moisture, and a clean process for facile preparation of an alcohol by oxidizing the organoborane so formed with hydrogen peroxide. The products, including aminodialkylboranes, ammonia trialkylborane complexes, as well as various alcohols so prepared, are within the scope of this disclosure.

公开(公告)号：US20190248725A1

公开(公告)日：2019-08-15

申请号：US16397139

申请日：2019-04-29

申请人： CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.

发明人： Imre JUHÁSZ ,  Irén HORTOBÁGYI ,  Tamás ALTSACH ,  István LÁSZLÓFI ,  Ágnes NAGYNÉ BORKÓ ,  Imre ROZSUMBERSZKI ,  Gábor HAVASI ,  Zsuzsanna KARDOS ,  Péter BUZDER-LANTOS

IPC分类号： C07C51/347 ,  C07C59/72 ,  C07C67/14 ,  C07C13/547 ,  C07C35/37 ,  C07C51/41 ,  C07C51/09 ,  C07C45/65 ,  C07C45/30 ,  C07C41/26 ,  C07C43/315 ,  C07C41/48 ,  C07C41/30 ,  C07C69/76 ,  C07C67/293 ,  C07C67/29

CPC分类号： C07C51/347 ,  C07C13/547 ,  C07C35/37 ,  C07C41/26 ,  C07C41/30 ,  C07C41/48 ,  C07C43/315 ,  C07C45/30 ,  C07C45/305 ,  C07C45/65 ,  C07C51/09 ,  C07C51/412 ,  C07C59/72 ,  C07C67/14 ,  C07C67/29 ,  C07C67/293 ,  C07C69/76 ,  C07C2603/14 ,  C07C49/84 ,  C07C49/755 ,  C07C59/70

摘要： Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.