公开(公告)号：US12103900B2

公开(公告)日：2024-10-01

申请号：US17904981

申请日：2021-11-11

申请人： LAXMI ORGANIC INDUSTRIES LTD

发明人： Ravi Goenka ,  Ajay A Audi

IPC分类号： C07C221/00

CPC分类号： C07C221/00

摘要： The present invention relates to an environment-friendly process for selective acylation of aminophenol. In particular, the present invention relates to an environment-friendly process for selective acylation of para-aminophenol to obtain N-acetyl-para-aminophenol (APAP).

公开(公告)号：US11739049B2

公开(公告)日：2023-08-29

申请号：US17142325

申请日：2021-01-06

申请人： GRÜNENTHAL GMBH

发明人： Wolfgang Hell ,  Oswald Zimmer ,  Helmut Heinrich Buschmann ,  Joerg Holenz ,  Stefan Gladow

IPC分类号： C07C213/00 ,  C07C213/08 ,  C07B57/00 ,  C07C221/00

CPC分类号： C07C213/00 ,  C07B57/00 ,  C07C213/08 ,  C07C221/00 ,  C07C213/00 ,  C07C215/54 ,  C07C213/00 ,  C07C217/62 ,  C07C213/08 ,  C07C215/54 ,  C07C213/08 ,  C07C217/62

摘要： The present invention relates to a process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.

公开(公告)号：US20190055189A1

公开(公告)日：2019-02-21

申请号：US15750420

申请日：2016-08-04

申请人： VAMSI LABS LTD.

发明人： G. Pratap REDDY ,  M. Kesava REDDY

IPC分类号： C07C213/08

CPC分类号： C07C213/08 ,  C07C213/00 ,  C07C215/68 ,  C07C221/00 ,  C07C225/22

摘要： Disclosed is a process for preparing β-agonist, 1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino) ethanol, of Formula I. The process comprises refluxing 1-(4-amino-3,5-dichlorophenyl) ethanone of Formula II and selenium dioxide in the presence of 1,4-dioxane to form compound of Formula III. Further, compound of Formula III is heated at a temperature below 30° C. in the presence of t-butyl amine to form compound of Formula IV. The compound of Formula IV is treated with sodium borohydride to form compound of Formula I.

公开(公告)号：US10081597B2

公开(公告)日：2018-09-25

申请号：US15320511

申请日：2014-11-03

申请人： Embio Limited

发明人： Ashutosh Digambar Gupte ,  Sunil Vaman Joshi ,  Amit Hari Pakhurde

IPC分类号： C07D211/34

CPC分类号： C07D211/34 ,  C07B2200/07 ,  C07C213/00 ,  C07C221/00 ,  C07C225/16 ,  C07C215/60 ,  C07C215/30

摘要： The present invention relates to a process for preparation of dexmethylphenidate hydrochloride from racemic methylphenidate. The process involves the treatment of racemic mixture of dl-threo-methylphenidate base in the presence of di-pivaloyl-D-tartaric acid (D-DPTA) in a solvent to isolate dipivaloyl tartrate salt of d-threo-methylphenidate. The dipivaloyl tartrate salt of d-threo-methylphenidate is treated with a base to obtain a d-threo-methylphenidate base, which is extracted using a suitable solvent. The d-threo-methylphenidate base is treated with hydrochloric acid-isopropyl alcohol solution to obtain slurry of d-threo-methylphenidate hydrochloride also known as dexmethylphenidate hydrochloride. The dexmethylphenidate hydrochloride slurry is filtered and washed with acetone. The invention also discloses a process for recovery of D-DPTA from the salt mother liquor and from the spent aqueous layer. The process is economical, environmental friendly and results in increased yield and optically pure dexmethylphenidate hydrochloride.

公开(公告)号：US10059661B1

公开(公告)日：2018-08-28

申请号：US15662452

申请日：2017-07-28

申请人： Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.

发明人： Shu-Hung Lin ,  Sheng-Po Huang ,  Show-Wen Liu ,  Cheng-Fang Hsu ,  Jenn-Tzong Chen ,  Shiou-Shiow Farn ,  Wuu-Jyh Lin ,  Chyng-Yann Shiue

IPC分类号： C07C303/12 ,  C07C303/44 ,  C07C253/34 ,  C07C253/30 ,  C07C45/79 ,  C07C45/65 ,  C07C221/00

CPC分类号： C07C303/12 ,  C07C45/64 ,  C07C45/65 ,  C07C45/79 ,  C07C213/04 ,  C07C213/08 ,  C07C221/00 ,  C07C253/30 ,  C07C253/34 ,  C07C303/28 ,  C07C303/44 ,  C07C49/83 ,  C07C255/42 ,  C07C309/73 ,  C07C225/22

摘要： A [F-18]FEONM precursor is synthesized. 2-bromoethanol is added to further connect an atom of oxygen at an N terminal of the precursor. Four atoms of carbon can be further connected. Thus, better fat-solubility is obtained along with the increase in carbon. Positioning in brain imaging becomes better.

公开(公告)号：US20180194753A1

公开(公告)日：2018-07-12

申请号：US15737483

申请日：2016-06-15

申请人： ZHEJIANG YONGTAI TECHNOLOGY CO., LTD

发明人： Hongming SHAO ,  Renbao HE ,  Yizhong JIN ,  Lei WANG

IPC分类号： C07D405/04 ,  C07D231/14 ,  C07C251/12 ,  C07C251/14

CPC分类号： C07D405/04 ,  C07B33/00 ,  C07C49/255 ,  C07C221/00 ,  C07C225/14 ,  C07C251/12 ,  C07C251/14 ,  C07D231/12 ,  C07D231/14 ,  C07D251/30 ,  C07D295/125

摘要： Provided are a preparation method for synthesizing a pyrazolecarboxylic acid derivative of the following formula (I), which is suitable for industrial production, and an intermediate as shown by the following formula (II). The method is high in reaction yield in each step, low in waste gas and waste water and low in cost, and requires no special reaction equipment.

公开(公告)号：US20180141030A1

公开(公告)日：2018-05-24

申请号：US15560942

申请日：2016-06-01

申请人： DALHOUSIE UNIVERSITY

发明人： Mark John STRADIOTTO

IPC分类号： B01J31/24 ,  B01J31/28 ,  C07C209/18 ,  C07C209/10 ,  C07C213/02 ,  C07C253/30 ,  C07C221/00 ,  C07F15/04 ,  C07F9/6571 ,  C07J41/00 ,  C07C225/22 ,  C07C217/90 ,  C07C217/92 ,  C07C211/58

CPC分类号： B01J31/2438 ,  B01J31/28 ,  C07C209/10 ,  C07C209/18 ,  C07C211/58 ,  C07C213/02 ,  C07C217/90 ,  C07C217/92 ,  C07C221/00 ,  C07C225/22 ,  C07C253/30 ,  C07F9/657163 ,  C07F15/04 ,  C07F15/045 ,  C07J41/0011 ,  C07C211/45 ,  C07C217/80 ,  C07C255/58 ,  C07C211/52 ,  C07C217/84

摘要： A compound having a chemical formula according to Formula (I) is disclosed where one of Z1, Z2 and Z3 is and one of the Z1, Z2, and Z3 that is bonded to a carbon atom that is adjacent to the carbon atom bonded to is P(AR1)(A′R2). Metal-based catalyst and pre-catalysts, such as nickel-based catalysts and precatalysts, where the metal is complexed to the compound are also disclosed. Methods of forming C(sp2)-N bonds are also disclosed.

公开(公告)号：US20180099917A1

公开(公告)日：2018-04-12

申请号：US15730428

申请日：2017-10-11

申请人： University of Kentucky Research Foundation

发明人： John Anthony ,  Susan A. Odom

IPC分类号： C07C50/12 ,  C07C211/57 ,  H01M8/18 ,  C07C211/42

CPC分类号： C07C50/12 ,  C07C211/42 ,  C07C211/57 ,  C07C221/00 ,  C07C225/30 ,  C07C303/10 ,  C07C309/46 ,  C07C309/53 ,  C07D209/86 ,  C07D241/04 ,  C07D279/22 ,  C07D295/116 ,  C07D317/70 ,  C07D319/22 ,  H01M8/188 ,  H01M2300/0025 ,  Y02E60/528

摘要： Provided herein are a reversibly reducible material and a method of forming a reversibly reducible material. The reversibly reducible material includes the molecular formula: wherein each of R1, R2, R3, and R4 are independently selected from the group consisting of hydrogen, oxygen, alkyl, cycloalkyl, O-alkyl, amine, quaternary ammonium, and sulfonate; R5 is selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, and amine; X is selected from the group consisting of hydrogen, branched or un-branched alkyl chain having 1-8 atoms containing 0-3 oxygen or nitrogen atoms, and substituted or unsubstituted aryl; and Z is selected from the group consisting of branched or un-branched alkyl chain having 1-8 atoms containing 0-3 oxygen or nitrogen atoms, and substituted or unsubstituted aryl. The method of forming a reversibly reducible material comprising reacting a quinone with an amine in an ethereal solvent. Also provided herein is a negolyte.

公开(公告)号：US20180079711A1

公开(公告)日：2018-03-22

申请号：US15561685

申请日：2015-12-17

申请人： SUZHOU PHARMAVAN CANCER RESEARCH CENTER CO., LTD.

发明人： Haimei Feng ,  Rensen Zhou ,  Xiang Chen ,  Yunhui Yu ,  Qian Liu ,  Yong Li ,  Shiping Deng ,  Chuangliang Jiang

IPC分类号： C07C225/12 ,  C07C221/00

CPC分类号： C07C225/12 ,  A61P35/00 ,  A61P37/00 ,  C07C221/00 ,  C07C2603/86 ,  C07D207/00 ,  C07D233/60 ,  C07D295/116 ,  C07D473/18

摘要： Provided is a glaucocalyxin A derivative, or salt thereof, as represented by the formula (I), a method for preparation of said glaucocalyxin A derivative, and a use for said glaucocalyxin A derivative in preparing pharmaceuticals for fighting autoimmune diseases and tumors, e.g. difficult-to-treat diseases such as systemic lupus erythematosus, psoriasis and triple-negative breast cancer

公开(公告)号：US09896479B2

公开(公告)日：2018-02-20

申请号：US14853806

申请日：2015-09-14

申请人： Kay M. Brummond

发明人： Kay M. Brummond ,  Laura S. Kocsis ,  Erica Benedetti

IPC分类号： C07K2/00 ,  A61K49/00 ,  C07D295/112 ,  C07C225/22 ,  C07C45/67 ,  C07C315/04 ,  C07F9/40 ,  C07C67/34 ,  G01N21/64 ,  C07C49/792 ,  C07C317/14 ,  C07D209/62 ,  C07C69/757 ,  C07C69/76 ,  C07C49/813 ,  C07F9/50 ,  C07F15/00 ,  C07D307/73 ,  C07C317/44 ,  A61K49/14 ,  C07K1/13

CPC分类号： C07K2/00 ,  A61K49/0021 ,  A61K49/14 ,  C07C45/67 ,  C07C47/55 ,  C07C49/792 ,  C07C49/813 ,  C07C67/34 ,  C07C69/757 ,  C07C69/76 ,  C07C69/78 ,  C07C221/00 ,  C07C225/22 ,  C07C305/00 ,  C07C315/04 ,  C07C317/14 ,  C07C317/44 ,  C07C2603/14 ,  C07D207/06 ,  C07D209/62 ,  C07D211/14 ,  C07D249/06 ,  C07D295/112 ,  C07D307/73 ,  C07D307/87 ,  C07F9/4015 ,  C07F9/4018 ,  C07F9/4021 ,  C07F9/4056 ,  C07F9/4075 ,  C07F9/5022 ,  C07F15/006 ,  C07K1/13 ,  G01N21/64

摘要： Methods for the synthesis and use of functionalized, substituted naphthalenes are described. The functionalized, substituted naphthalenes display useful properties including liquid crystals and fluorescence properties, such as solvatochromatic fluorescence, with high quantum yields, Stoke's shift, and show emission maxima that are significantly red-shifted.