公开(公告)号：US20240182407A1

公开(公告)日：2024-06-06

申请号：US18549596

申请日：2022-03-08

申请人： Nanjing Zenshine Pharmaceuticals Co., Ltd.

发明人： Xiaolin Hao

IPC分类号： C07C309/73 ,  A61K31/255 ,  A61K31/506 ,  C07C303/26 ,  C07C303/44 ,  C07D401/14

CPC分类号： C07C309/73 ,  A61K31/255 ,  A61K31/506 ,  C07C303/26 ,  C07C303/44 ,  C07D401/14 ,  C07B2200/13

摘要： The present invention relates to the field of biomedicine; provided are a quinoline compound salt or a crystal form thereof, a preparation method therefor and an application thereof. The quinoline compound is as shown in Formula (I), and the provided salt may be used as an inhibitor of phosphoinositide 3-kinase for the treatment of diseases related to phosphoinositide 3-kinase. More particularly, the compound of Formula (I) may be 2,4-diamino-6-[1-(7-fluoro-2-pyridin-2-yl-quinolin-3-yl)-ethylamino]-pyrimidine-5-carbonitrile (Compound A), the structure thereof being as shown below. Crystal form I of p-toluenesulfonate of the compound may be used as an inhibitor of phosphoinositide 3-kinase for the treatment of diseases related to phosphoinositide 3-kinase.

公开(公告)号：US11970439B1

公开(公告)日：2024-04-30

申请号：US18385147

申请日：2023-10-30

申请人： KING FAISAL UNIVERSITY

发明人： Hany Mohamed Abd El-Lateef Ahmed ,  Mai Mostafa Khalaf Ali ,  Antar Ahmed Abdelhamid Ahmed ,  Amer A. Amer

IPC分类号： C07C309/47 ,  A61P39/06 ,  C07C303/22 ,  C07C303/44

CPC分类号： C07C309/47 ,  A61P39/06 ,  C07C303/22 ,  C07C303/44

摘要： An 8-(4-chlorobenzylideneamino)naphthalene-1,3-disulfonic acid compound, its synthesis, and its use as an antioxidant agent.

公开(公告)号：US11851395B2

公开(公告)日：2023-12-26

申请号：US18110978

申请日：2023-02-17

申请人： Vitaworks IP, LLC

发明人： Songzhou Hu

IPC分类号： C07C303/32 ,  C07C303/02 ,  C07C303/22 ,  C07C309/14 ,  C07C303/44 ,  B01J23/04

CPC分类号： C07C303/32 ,  C07C303/02 ,  C07C303/22 ,  C07C303/44 ,  C07C309/14 ,  B01J23/04

摘要： There is disclosed a process for producing taurine in a molar yield of at least 80% from alkali isethionate, alkali ditaurinate, or alkali tritaurinate by adding excess ammonia and at least of equal molar amount of an alkali hydroxide to a solution comprised of alkali ditaurinate, alkali tritaurinate, or their mixture and subjecting the solution to an ammonolysis to yield a solution comprised of alkali taurinate.

公开(公告)号：US11840502B2

公开(公告)日：2023-12-12

申请号：US17808925

申请日：2022-06-24

申请人： HUBEI GRAND LIFE SCIENCE AND TECHNOLOGY CO., LTD.

发明人： Huajun Sun ,  Min Tan ,  Xiaojing Yan ,  Ruyong Jiang ,  Hongbo Peng ,  Jiale Tang ,  Chen Guo ,  Xingxing Wang ,  Zhiqiang Qian

IPC分类号： B01D15/36 ,  C07C303/22 ,  C07C303/44

CPC分类号： C07C303/22 ,  B01D15/363 ,  C07C303/44

摘要： The present disclosure provides a system for efficiently preparing taurine, including: a solution storage unit configured to store a solution containing alkali metal taurinate, the solution being prepared by an ethylene oxide process; an ion exchange unit including at least one ion exchange resin column each configured to be activated by a first activation manner or a second activation manner independently, the first activation manner using sulfurous acid for activation to obtain alkali metal bisulfate and taurine, and the second activation manner using sulfuric acid for activation to obtain alkali metal sulfate and taurine; and a dispensing unit connected to the solution storage unit and the ion exchange unit respectively, and configured to adjust an amount of a solution conveyed from the solution storage unit to each of the at least one ion exchange resin column in the ion exchange unit.

公开(公告)号：US11773056B2

公开(公告)日：2023-10-03

申请号：US17402617

申请日：2021-08-16

申请人： QIANJIANG Yongan Pharmaceutical CO., LTD.

发明人： Yong Chen ,  Xiquan Fang ,  Shaobo Li ,  Feng Liu

IPC分类号： C07C303/22 ,  C07C303/44 ,  C07C303/02 ,  C07C303/32

CPC分类号： C07C303/22 ,  C07C303/02 ,  C07C303/32 ,  C07C303/44 ,  C07C303/22 ,  C07C309/14 ,  C07C303/02 ,  C07C309/08 ,  C07C303/44 ,  C07C309/14 ,  C07C303/32 ,  C07C309/08 ,  C07C303/32 ,  C07C309/14

摘要： The present invention discloses a method for preparing taurine. According to the method, ethylene oxide reacts with hydrogen sulfite to generate isethionate, after the isethionate and ammonia are subjected to an ammonolysis reaction under a microwave condition, ammonia removal is conducted to obtain a taurine salt solution, the taurine salt solution is converted into a taurine solution through acidification or ion exchange or ion membrane or heating, and taurine is extracted through concentration and crystallization. According to the present invention, the reaction time can be shortened, and the reaction temperature and pressure can be reduced, thereby achieving high yield and reducing energy consumption.

公开(公告)号：US20230192603A1

公开(公告)日：2023-06-22

申请号：US18110978

申请日：2023-02-17

申请人： Vitaworks IP, LLC

发明人： Songzhou Hu

IPC分类号： C07C303/32 ,  C07C303/02 ,  C07C303/22 ,  C07C309/14 ,  C07C303/44

CPC分类号： C07C303/32 ,  C07C303/02 ,  C07C303/22 ,  C07C309/14 ,  C07C303/44 ,  B01J23/04

摘要： There is disclosed a process for producing taurine in a molar yield of at least 80% from alkali isethionate, alkali ditaurinate, or alkali tritaurinate by adding excess ammonia and at least of equal molar amount of an alkali hydroxide to a solution comprised of alkali ditaurinate, alkali tritaurinate, or their mixture and subjecting the solution to an ammonolysis to yield a solution comprised of alkali taurinate.

公开(公告)号：US20230174446A1

公开(公告)日：2023-06-08

申请号：US18102141

申请日：2023-01-27

申请人： AGC INC.

发明人： Takuya IWASE ,  Motoshi AOYAMA

IPC分类号： C07C43/12 ,  C07C309/80 ,  C07C41/34 ,  C07C303/44

CPC分类号： C07C43/126 ,  C07C309/80 ,  C07C41/34 ,  C07C303/44

摘要： To provide a method for producing a fluorinated ether compound having a poly(oxyfluoroalkylene) chain and a sulfonate group with low impurity content and in high yield.
A method for producing a fluorinated ether compound, comprising



step 1 of sulfonylating a fluorinated ether compound having a poly(oxyfluoroalkylene) chain and a hydroxy group in the presence of a fluorinated solvent, a base and a sulfonylating agent to obtain a product containing a fluorinated ether compound having a poly(oxyfluoroalkylene) chain and a sulfonate group, and
step 2 of contacting the product obtained in step 1 with an adsorbent having a pH of at most 8.0.

公开(公告)号：US20190225626A1

公开(公告)日：2019-07-25

申请号：US16315270

申请日：2016-09-06

申请人： BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.

发明人： MANIK REDDY PULLAGURLA ,  MECHERIL VALSAN NANDA KUMAR ,  BHASKAR REDDY PITTA ,  SURESH BABU NAMANA ,  JAGADEESH BABU RANGISETTY ,  SADASHIV CHOPPARI

IPC分类号： C07F1/04

CPC分类号： C07F1/04 ,  C07B2200/13 ,  C07C303/00 ,  C07C303/04 ,  C07C303/06 ,  C07C303/22 ,  C07C303/44 ,  C07C309/44 ,  C07C309/46

摘要： Provided is an improved process for the preparation N-[4-[[4-(diethyl amino) phenyl](2,5-disulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-N-ethylethanaminium inner salt sodium salt (Isosulfan blue) of formula I. It also relates to highly pure novel crystalline form of Isosulfan blue hydrate and its process for the preparation thereof. It also relates to an improved process for the preparation of Isosulfan blue sodium hydrate having not more than 0.2% of desethyl impurity of formula A.

公开(公告)号：US10071955B1

公开(公告)日：2018-09-11

申请号：US15678737

申请日：2017-08-16

申请人： QIANJIANG YONGAN PHARMACEUTICAL CO., LTD.

发明人： Yong Chen ,  Xiquan Fang ,  Shaobo Li

IPC分类号： C07C309/00 ,  C07C303/02 ,  C07C303/22 ,  B01D15/36 ,  B01J49/53 ,  B01J27/232 ,  C07C303/44

CPC分类号： C07C303/02 ,  B01D15/362 ,  B01J27/232 ,  B01J49/53 ,  C07C303/22 ,  C07C303/32 ,  C07C303/44 ,  C07C309/14 ,  C07C309/08

摘要： The high-yield circular production method of taurine includes the following steps: S1, ethylene oxide reacts with sodium bisulfite solution to generate sodium hydroxyethyl sulfonate; S2, sodium hydroxyethyl sulfonate obtained in S1 is subjected to ammonolysis reaction in ammonia, and ammonia gas is recycled through flash evaporation upon completion of the reaction; S3, a reaction solution obtained after flash evaporation in S2 is sent to pass through an acidic cation exchange resin column, a material liquid containing taurine is collected, the inactivated resin column is subjected to regeneration with sulfur dioxide or carbon dioxide aqueous solution, and an eluent acquired during regeneration can be recycled directly or recycled after treated by sulfur dioxide; S4, the material liquid collected in S3 is subjected to post treatment to acquire taurine.

公开(公告)号：US09926266B2

公开(公告)日：2018-03-27

申请号：US15292106

申请日：2016-10-12

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Hyoung-Juhn Kim ,  Eun Ki Kim ,  So Young Lee ,  Jong Hyun Jang ,  Jin Young Kim ,  Sung Jong Yoo ,  Dirk Henkensmeier ,  Dae Ki Choi ,  Jonghee Han ,  Suk Woo Nam

IPC分类号： C07C303/44 ,  C07C303/32 ,  C07C309/24

CPC分类号： C07C303/44 ,  C07C303/32 ,  C07C309/24

摘要： Disclosed are a method for preparing a pure isophthalaldehyde bisulfite adduct free from impurities through a specific purification process, and use thereof as a starting material for polymerizing polybenzimidazole under a mild condition. According to the present disclosure, it is possible to obtain a pure isophthalaldehyde bisulfite adduct free from impurities, such as unreacted materials or byproducts. In addition, it is possible to accomplish industrial mass production of a high-molecular weight polybenzimidazole by using the adduct as a starting material for polymerizing polybenzimidazole under a mild condition in an organic solvent.