公开(公告)号：US20240066002A1

公开(公告)日：2024-02-29

申请号：US18371722

申请日：2023-09-22

申请人： Cardioxyl Pharmaceuticals, Inc.

发明人： Vincent Jacob Kalish ,  Frederick Arthur Brookfield ,  Stephen Martin Courtney ,  Lisa Marie Frost ,  John P. Toscano

IPC分类号： A61K31/341 ,  A61K9/00 ,  A61K9/08 ,  A61K31/18 ,  A61K31/222 ,  A61K31/24 ,  A61K31/255 ,  A61K31/343 ,  A61K31/381 ,  A61K31/404 ,  A61K31/42 ,  A61K31/433 ,  A61K31/4436 ,  A61K31/5377 ,  A61K31/538 ,  A61K47/12 ,  A61K47/40 ,  A61P9/04 ,  C07C317/14 ,  C07D307/64

CPC分类号： A61K31/341 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/18 ,  A61K31/222 ,  A61K31/24 ,  A61K31/255 ,  A61K31/343 ,  A61K31/381 ,  A61K31/404 ,  A61K31/42 ,  A61K31/433 ,  A61K31/4436 ,  A61K31/5377 ,  A61K31/538 ,  A61K47/12 ,  A61K47/40 ,  A61P9/04 ,  C07C317/14 ,  C07D307/64

摘要： The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

公开(公告)号：US11771749B2

公开(公告)日：2023-10-03

申请号：US16483332

申请日：2018-02-05

申请人： THE MEDICAL COLLEGE OF WISCONSIN, INC.

发明人： Jing Pan ,  Ming You ,  Ronald Lubet

IPC分类号： A61K39/00 ,  A61P35/00 ,  A61K31/192 ,  A61K31/203 ,  A61K45/06 ,  A61K31/255

CPC分类号： A61K39/001164 ,  A61K31/192 ,  A61K31/203 ,  A61K31/255 ,  A61K45/06 ,  A61P35/00 ,  A61K2039/55505 ,  A61K2039/55522 ,  A61K2039/55572 ,  A61K2039/86

摘要： The present disclosure provides compositions and methods of eliciting an anti-tumor immune response and treating cancer comprising at least one peptide of KRAS.

公开(公告)号：US11771736B2

公开(公告)日：2023-10-03

申请号：US16766741

申请日：2018-12-21

申请人： Mainline Biosciences (Shanghai) Co., Ltd.

发明人： Junge Zhang ,  Liang Zeng Yan

IPC分类号： A61K38/12 ,  A61P35/00 ,  A61K33/243 ,  A61K38/14 ,  A61K38/50 ,  A61K39/395 ,  A61K38/00 ,  C07K7/06 ,  A61K31/255 ,  A61K31/282 ,  A61K31/337 ,  A61K31/475 ,  A61K31/565 ,  A61K31/7048 ,  A61K31/7068

CPC分类号： A61K38/12 ,  A61K33/243 ,  A61K38/00 ,  A61K38/14 ,  A61K38/50 ,  A61K39/3955 ,  A61P35/00 ,  C07K7/06 ,  A61K31/255 ,  A61K31/282 ,  A61K31/337 ,  A61K31/475 ,  A61K31/565 ,  A61K31/7048 ,  A61K31/7068

摘要： The present invention provides a composition comprising a therapeutic agent and a C-X-C chemokine receptor type 4 (CXCR4) antagonist, and methods for using the same. Compositions and methods of the invention can be used to treat cancer, viral infection, immune disorders (e.g., rheumatoid arthritis), pulmonary fibrosis, or any other clinical condition associated with abnormal expression (e.g., overexpression and/or upregulation) of CXCR4. Compounds of the invention can also be used in stem cell therapeutics.

公开(公告)号：US20230218679A1

公开(公告)日：2023-07-13

申请号：US18095468

申请日：2023-01-10

申请人： Viva Life Science, Inc.

发明人： Thuong Cao Do

IPC分类号： A61K35/60 ,  A61K9/00 ,  A61K36/55 ,  A61K31/255 ,  A61K31/202 ,  A61K36/48 ,  A61K36/8962 ,  A61K36/752 ,  A61K45/06 ,  A61K31/352

CPC分类号： A61K35/60 ,  A61K9/0053 ,  A61K36/55 ,  A61K31/255 ,  A61K31/202 ,  A61K36/48 ,  A61K36/8962 ,  A61K36/752 ,  A61K45/06 ,  A61K31/352

摘要： The present invention relates to nutritional supplements for the human diet used to manipulate HDL cholesterol, LDL cholesterol, and triglyceride levels in human blood plasma. The invention contains a novel combination of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) present in Fish Oil, alpha-linolenic acid (ALA) present in Flaxseed Oil, Vitamin E in the form of d-alpha-tocopherol, Allicin present in Garlic, Phosphatidylcholine present in Lecithin, plant phytochemicals present in Parsley herb, citrus flavonoids present in Lemon fruit and Rutin (from Sophora japonica), and Capsaicin present in Cayenne Pepper.

公开(公告)号：US10047116B2

公开(公告)日：2018-08-14

申请号：US14349142

申请日：2012-10-01

申请人： MX Adjuvac AB

发明人： Bror Morein ,  Saideh Berenjian ,  Kafei Hu

IPC分类号： A61K39/00 ,  C07J9/00 ,  A61K31/255 ,  A61K31/337 ,  A61K31/52 ,  A61K31/593 ,  A61K31/704 ,  A61K31/7068 ,  A61K39/145 ,  A61K39/39 ,  A61K36/73 ,  C12Q1/48 ,  G01N33/50 ,  A61K9/51 ,  A61K39/12

CPC分类号： C07J9/00 ,  A61K9/5123 ,  A61K31/255 ,  A61K31/337 ,  A61K31/52 ,  A61K31/593 ,  A61K31/704 ,  A61K31/7068 ,  A61K36/73 ,  A61K39/12 ,  A61K39/145 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/55555 ,  A61K2039/55577 ,  A61K2300/00 ,  C12N2760/16134 ,  C12N2760/16234 ,  C12Q1/485 ,  G01N33/5011 ,  G01N2800/52 ,  Y10T428/2982

摘要： The present invention regards nanoparticles comprising a sterol and a component derived from Quillaja saponaria Molina selected from quillaja acid and quillaja saponin, which nanoparticles do not comprise a phospholipid. It also relates to a composition comprising the nanoparticles, and the use thereof as adjuvant, especially in vaccines, as carriers for amphipathic or hydrophobic molecules and as agents for treatment of cancer. Further, it regards a method for producing the phospholipid-free nanoparticles, a method for the treatment of cancer and a method for assessing the applicability of the cancer treating method.

公开(公告)号：US20180125936A1

公开(公告)日：2018-05-10

申请号：US15564183

申请日：2016-03-23

申请人： PARANTA BIOSCIENCES LIMITED

发明人： David N. WATKINS ,  Kieren D. MARINI ,  David Morritz DE KRETSER

IPC分类号： A61K38/18 ,  A61K31/255 ,  A61K31/4439 ,  A61K31/555 ,  A61K33/24 ,  A61K38/17 ,  A61K38/22 ,  A61K39/00 ,  A61K45/00 ,  A61P35/00

CPC分类号： A61K38/18 ,  A61K31/255 ,  A61K31/4439 ,  A61K31/555 ,  A61K33/24 ,  A61K38/1709 ,  A61K38/177 ,  A61K38/22 ,  A61K39/00 ,  A61K39/0011 ,  A61K45/05 ,  A61K45/06 ,  A61K2300/00 ,  A61P35/00 ,  C12N2310/127 ,  C12N2310/16

摘要： The present invention relates generally to a method of treating a neoplastic condition. More particularly, the present invention is directed to a method of selectively sensitising neoplastic cells prior to chemotherapy. The method of the present invention is predicated on administering chemotherapy treatment subsequently to neoplastic cell sensitisation via the exposure of these cells to an activin type 1 B receptor (ACVR1B) antagonist. The present findings have now enabled the development of a new neoplastic treatment regime exhibiting both higher efficacy and reduced side effects for patients and, still further, a means of effectively treating chemoresistant neoplasms.

公开(公告)号：US20180009943A1

公开(公告)日：2018-01-11

申请号：US15545272

申请日：2016-01-20

申请人： FREIE UNIVERSITAET BERLIN ,  THE UNIVERSITY OF BRITISH COLUMBIA

发明人： Donald BROOKS ,  Jayachandran KIZHAKKEDATHU ,  Rajesh SHENOI ,  Marie WEINHART ,  Benjamin LAI ,  Rainer HAAG ,  Dominic GROEGER

IPC分类号： C08G65/334 ,  A61K31/255 ,  A61K38/36

CPC分类号： C08G65/3344 ,  A61K31/255 ,  A61K38/36 ,  C08G65/32 ,  C08G2650/54

摘要： The invention relates to a linear polyglycerol compound, comprising a backbone of linearly linked glycerol residues. This compound is characterized in that it carries a plurality of substituents in the nature of covalently bound sulfates, wherein a degree of substitution of the backbone is preferably between 30 and 100%. A method of manufacturing the compound as well as uses of this compound and similar compounds are also disclosed.

公开(公告)号：US20170362593A1

公开(公告)日：2017-12-21

申请号：US15536437

申请日：2015-12-21

申请人： Centre National De La Recherche Scientifique

发明人： Domenico Maiorano

IPC分类号： C12N15/113 ,  A61K31/381 ,  G01N33/574 ,  A61K31/713 ,  C12Q1/68

CPC分类号： C12N15/1137 ,  A61K31/255 ,  A61K31/381 ,  A61K31/4745 ,  A61K31/555 ,  A61K31/7105 ,  A61K31/713 ,  A61K33/24 ,  C07K16/18 ,  C07K16/40 ,  C12N9/93 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/31 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Y203/02 ,  C12Y603/02 ,  G01N33/57496 ,  G01N2333/9108 ,  G01N2800/52

摘要： The present invention relates to the use of an inhibitor of Rad18 expression or activity, in treating a tumor or in sensitizing a patient affected with a tumor, to a treatment with an antineoplastic agent that is a DNA damaging chemotherapeutic agent so to both reduce the self renewal of cancer stem cells and increase the DNA damage response thus boosting apoptotic cell death.

公开(公告)号：US20170333483A1

公开(公告)日：2017-11-23

申请号：US15651416

申请日：2017-07-17

申请人： CHILDREN'S MEDICAL CENTER CORPORATION

发明人： Leonard I. Zon ,  Pulin Li

IPC分类号： A61K35/28 ,  A61K31/19 ,  C12N5/0789 ,  A61K31/255 ,  A61K31/221 ,  A61K31/21 ,  A61K31/095 ,  A61K35/12

CPC分类号： A61K35/28 ,  A61K31/095 ,  A61K31/19 ,  A61K31/21 ,  A61K31/221 ,  A61K31/255 ,  A61K2035/124 ,  C12N5/0647 ,  C12N2500/36 ,  C12N2501/999

摘要： Described herein are methods for enhancing engraftment of hematopoietic stem and progenitor cells using farnesyl compounds identified using a zebrafish model of hematopoietic cell engraftment. The compounds can be used to treat hematopoietic stem cells ex vivo prior to transplantation of the cells. Alternatively, the compounds can be administered to an individual undergoing cell transplantation.

公开(公告)号：US09821008B2

公开(公告)日：2017-11-21

申请号：US15038585

申请日：2014-11-25

申请人： The University of Toledo

发明人： Stephan M. Patrick ,  Paul W. Erhardt ,  Christopher Trabbic

IPC分类号： A61K33/24 ,  A61K31/185 ,  A61K45/06 ,  A61K31/255 ,  C07C309/47 ,  C07C309/67 ,  C07C309/73 ,  C07C317/36 ,  C07C323/66

CPC分类号： A61K33/24 ,  A61K31/185 ,  A61K31/255 ,  A61K45/06 ,  C07C309/47 ,  C07C309/67 ,  C07C309/73 ,  C07C317/36 ,  C07C323/66 ,  A61K2300/00

摘要： Compositions and methods for inhibiting the DNA repair protein complex, ERCC1-XPF, and methods to enhance clinical responses to anticancer drugs that interact with DNA such as cisplatin, and to overcome drug resistance due to DNA repair mechanisms, are described.