公开(公告)号：US20240326380A1

公开(公告)日：2024-10-03

申请号：US18615152

申请日：2024-03-25

申请人： The University of Toledo

发明人： Yakov Lapitsky ,  Maria R. Coleman ,  Joseph G. Lawrence ,  Jose C. Benalcazar Bassante

IPC分类号： B32B7/10 ,  B32B27/08 ,  B32B27/32 ,  B32B27/36 ,  B32B43/00

CPC分类号： B32B7/10 ,  B32B27/08 ,  B32B27/32 ,  B32B27/36 ,  B32B43/006 ,  B32B2307/308 ,  B32B2307/7244 ,  B32B2553/00

摘要： Coacervate compositions, tie layers, coatings, moldable viscoelastic materials, sustained release materials, kits for making coacervate compositions, and methods of using and making the same are described. A coacervate composition may include a complex between a surfactant and a polyelectrolyte in a solvent, where the surfactant includes a cis double bond.

公开(公告)号：US20240325790A1

公开(公告)日：2024-10-03

申请号：US18580987

申请日：2022-07-21

申请人： The University of Toledo

发明人： E. Ishmael Parsai ,  Diana Shvydka ,  Kanru Xie

IPC分类号： A61N5/10

CPC分类号： A61N5/1071 ,  A61N2005/1076

摘要： Provided is a device comprising a phantom comprising a solid water material, having a square cross-sectional shape, and having a width that varies monotonically along a height of the solid phantom; and an array of radiation detectors disposed within the phantom; wherein the array of radiation detectors is configured to detect radiation within the phantom. Further provided is a linear accelerator having a gantry and comprising the device as described herein installed in a treatment head of the gantry. In certain embodiments, the linear accelerator further comprises software to interface the device with the linear accelerator.

公开(公告)号：US20240245667A1

公开(公告)日：2024-07-25

申请号：US18621480

申请日：2024-03-29

申请人： The University of Toledo

发明人： Amit K. Tiwari ,  Chandrabose Karthikeyan ,  Haneen A. Amawi ,  Paul W. Erhardt ,  Piyush Trivedi

IPC分类号： A61K31/4439 ,  A61K31/122 ,  C07D401/14 ,  C07D513/04

CPC分类号： A61K31/4439 ,  A61K31/122 ,  C07D401/14 ,  C07D513/04

摘要： Compounds, compositions, and methods useful for inducing cancer cell death via methuosis, autophagy, or a combination thereof, are described. The compounds have a 4-pyridyl group linked by a heterocyclic group to an aryl, heteroaryl, aralkyl, or heteroaryl alkyl.

公开(公告)号：US11992708B2

公开(公告)日：2024-05-28

申请号：US16585962

申请日：2019-09-27

申请人： The University of Toledo

发明人： E. Ishmael Parsai ,  Mohammad Elahinia

IPC分类号： A61N5/01 ,  A61B6/10 ,  A61N5/10

CPC分类号： A61N5/1069 ,  A61N5/1049 ,  A61N5/1077

摘要： Devices, systems, and methods for repositioning organs, such as the rectum, during radiation therapy treatments, are described.

公开(公告)号：US20240092932A1

公开(公告)日：2024-03-21

申请号：US18506571

申请日：2023-11-10

申请人： The University of Toledo

发明人： Peter Andreana ,  Kevin Trabbic ,  Mengchao Shi ,  Jean Paul Bourgault

IPC分类号： C07K16/30 ,  A61K39/00 ,  A61K39/39 ,  A61K39/395 ,  A61K47/61 ,  A61K47/68 ,  A61P35/00 ,  C12N5/12

CPC分类号： C07K16/30 ,  A61K39/001172 ,  A61K39/001173 ,  A61K39/39 ,  A61K39/39558 ,  A61K47/61 ,  A61K47/6855 ,  A61P35/00 ,  C12N5/12

摘要： Entirely carbohydrate immunogens, monoclonal antibodies generated from immune responses to entirely carbohydrate immunogens, vaccine compositions, pharmaceutical compositions, and methods of making and using the same, are described.

公开(公告)号：US20240081969A1

公开(公告)日：2024-03-14

申请号：US17944622

申请日：2022-09-14

申请人： The University of Toledo

发明人： Munier Nazzal ,  Abdullah Nasif ,  Mohamed Fikri Mohamed Osman ,  Ayman Ahmed ,  Sakeena Davis ,  Soheila Alidad ,  Zahra Alzaher ,  Ghayth M. Ansarei

IPC分类号： A61F2/01

CPC分类号： A61F2/011 ,  A61F2/0105

摘要： An IVC filter retrieval device useful for removing an IVC filter from a blood vessel, and useful for removing a tilted IVC filter causing the hook to be embedded in the side (wall) of a blood vessel from the blood vessel, and methods for using the same are described. The IVC retrieval device can be used to retrieve other foreign bodies such as, but not limited to, catheters and wires that may become detached from their devices and released into the blood vessels.

公开(公告)号：US11897852B2

公开(公告)日：2024-02-13

申请号：US17172543

申请日：2021-02-10

申请人： The University of Toledo

发明人： Bruce E. Heck ,  Dong Hyun Kim ,  Paul W. Erhardt ,  Brian Kress

IPC分类号： A61K31/426 ,  A61P19/02 ,  C07D277/24 ,  A61K31/5575 ,  A61K45/06 ,  C07D277/28 ,  C07D277/22

CPC分类号： C07D277/24 ,  A61K31/426 ,  A61K31/5575 ,  A61K45/06 ,  C07D277/22 ,  C07D277/28 ,  A61K31/5575 ,  A61K2300/00 ,  A61K31/426 ,  A61K2300/00

摘要： Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.

公开(公告)号：US20230128972A1

公开(公告)日：2023-04-27

申请号：US17794911

申请日：2021-01-29

申请人： Atomwise Inc. ,  The University of Toledo

发明人： Ronald E. Viola ,  Adrian Stecula

IPC分类号： A61K31/498 ,  A61K31/505 ,  A61K31/433 ,  A61K31/4365 ,  A61K31/4245

摘要： Inhibitors of a critical brain enzyme, N-acetyltransferase (ANAT), and methods of discovering, making and using the same for the treatment of disease are disclosed.

公开(公告)号：US11607677B2

公开(公告)日：2023-03-21

申请号：US16759065

申请日：2018-10-29

申请人： The University of Toledo

发明人： Ana C. Alba Rubio ,  Maria R. Coleman ,  Subhash Kalidindi ,  Anup S. Joshi ,  Ibeh S. Omodolor

IPC分类号： B01J31/10 ,  C01B32/182 ,  B01J31/06 ,  B01J37/30 ,  C07D307/48 ,  B82Y30/00 ,  B82Y40/00

摘要： A superacid polymeric catalyst having both Lewis acidity and Brønsted acidity is described, along with methods of making and methods of using the same.

公开(公告)号：US11559928B2

公开(公告)日：2023-01-24

申请号：US16795930

申请日：2020-02-20

申请人： The University of Toledo

发明人： Syed Reza Rizvi ,  Sheikh Rasel ,  Md Emran Hossain Bhuiyan ,  Navid Namdari ,  Bilal Nizar Abdul Halim

IPC分类号： B32B5/18 ,  C08J9/12 ,  B29C44/34 ,  B29C43/22 ,  B29K9/06 ,  B29K77/00 ,  B29K105/04

摘要： Materials that exhibit stress-induced porosity, and methods of making and using the same, are described.