知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

1567 条记录 (耗时 0.029 秒)

    BIODEGRADABLE DRUG-POLYMER CONJUGATE
    4.
    发明公开
    BIODEGRADABLE DRUG-POLYMER CONJUGATE 审中-公开

    公开(公告)号：US20240247106A1

    公开(公告)日：2024-07-25

    申请号：US18226713

    申请日：2023-07-26

    申请人： POLYACTIVA PTY LTD

    发明人： Stephen Lonsdale BIRKETT ,  Andrew Craig DONOHUE ,  Asha Marina D'SOUZA ,  Sarah Man Yee NG ,  Adrian SULISTIO ,  Russell John TAIT ,  David VALADE ,  Alan NAYLOR ,  Jason WATLING ,  Carmen Vittoria SCULLINO

    IPC分类号： C08G73/08 ,  A61K31/5377 ,  A61K31/5575 ,  A61K47/59

    CPC分类号： C08G73/08 ,  A61K31/5377 ,  A61K31/5575 ,  A61K47/59

    摘要： A drug-polymer conjugate, which is a copolymer of at least one monomer of formula (I): (I) where: X may be the same or different at each occurrence and represents a terminal functional group comprising an alkyne or an azide; Q is independently selected at each occurrence and may be present or absent and when present, represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon, optionally substituted aryl and optionally substituted heteroaryl; D is a releasable drug selected from prostaglandins, β-blockers and mixtures thereof; L is a linker group group; and at least one co-monomer of Formula III III J represents a linking functional group, n is 2 to 8, preferably 3 to 8; Y comprises a polyether of formula (ORa)m wherein Ra is independently ethylene, propylene and butylene and m is from 1 to 300 (preferably 2 to 300) and the polyether is in chain with one or more groups which are preferably selected from one or more of optionally substituted straight or branched Ci to do alkylene, amino, ether, ester, amide, carbonate and carbamate; A may be the same or different at each occurrence and represents a group comprising a terminal functional group comprising an alkyne or an azide functionality, wherein said terminal functional group is complementary to the terminal functional group X of formula (I) providing triazole moieties from reaction of X and A.

    COMPOSITIONS AND TECHNIQUES FOR VAGINAL INSERTION
    6.
    发明公开
    COMPOSITIONS AND TECHNIQUES FOR VAGINAL INSERTION 审中-公开

    公开(公告)号：US20240189265A1

    公开(公告)日：2024-06-13

    申请号：US18292097

    申请日：2022-07-25

    申请人： Daré Bioscience, Inc.

    发明人： David Friend ,  Jennifer Kiang ,  Nicolas J. Pacelli ,  Mark Walters

    IPC分类号： A61K31/196 ,  A61K9/00 ,  A61K9/06 ,  A61K31/5575 ,  A61K47/10 ,  A61K47/12 ,  A61K47/34 ,  A61K47/36

    CPC分类号： A61K31/196 ,  A61K9/0034 ,  A61K9/06 ,  A61K31/5575 ,  A61K47/10 ,  A61K47/12 ,  A61K47/34 ,  A61K47/36

    摘要： The present disclosure generally relates to compositions and techniques for vaginal insertion. In some embodiments, a composition such as a gel may be applied to the vagina of a subject that is relatively viscous, for example, with a viscosity at room temperature of at least 1.5 million cP. The composition may also contain an active ingredient, e.g., dinoprostone, diclofenac, and/or salts thereof. Compositions having such relatively high viscosities may be useful, for example, to prevent the composition from readily exiting the vagina or degrading too quickly. This may, for example, allow the composition to release the active ingredient over a relatively long period of time to the vagina. In some embodiments, such compositions may be prepared by removing air from the composition to increase its viscosity or cause the composition to form a gel, etc. In addition, certain embodiments as described herein are generally directed to techniques for making or using such compositions, kits including such compositions, or the like.