- 专利标题: BIODEGRADABLE DRUG-POLYMER CONJUGATE
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申请号: US18226713申请日: 2023-07-26
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公开(公告)号: US20240247106A1公开(公告)日: 2024-07-25
- 发明人: Stephen Lonsdale BIRKETT , Andrew Craig DONOHUE , Asha Marina D'SOUZA , Sarah Man Yee NG , Adrian SULISTIO , Russell John TAIT , David VALADE , Alan NAYLOR , Jason WATLING , Carmen Vittoria SCULLINO
- 申请人: POLYACTIVA PTY LTD
- 申请人地址: AU Melbourne
- 专利权人: POLYACTIVA PTY LTD
- 当前专利权人: POLYACTIVA PTY LTD
- 当前专利权人地址: AU Melbourne, Victoria
- 优先权: AU 17900888 2017.03.14
- 主分类号: C08G73/08
- IPC分类号: C08G73/08 ; A61K31/5377 ; A61K31/5575 ; A61K47/59
摘要:
A drug-polymer conjugate, which is a copolymer of at least one monomer of formula (I): (I) where: X may be the same or different at each occurrence and represents a terminal functional group comprising an alkyne or an azide; Q is independently selected at each occurrence and may be present or absent and when present, represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon, optionally substituted aryl and optionally substituted heteroaryl; D is a releasable drug selected from prostaglandins, β-blockers and mixtures thereof; L is a linker group group; and at least one co-monomer of Formula III III J represents a linking functional group, n is 2 to 8, preferably 3 to 8; Y comprises a polyether of formula (ORa)m wherein Ra is independently ethylene, propylene and butylene and m is from 1 to 300 (preferably 2 to 300) and the polyether is in chain with one or more groups which are preferably selected from one or more of optionally substituted straight or branched Ci to do alkylene, amino, ether, ester, amide, carbonate and carbamate; A may be the same or different at each occurrence and represents a group comprising a terminal functional group comprising an alkyne or an azide functionality, wherein said terminal functional group is complementary to the terminal functional group X of formula (I) providing triazole moieties from reaction of X and A.
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