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公开(公告)号：US20240336895A1
公开(公告)日：2024-10-10
申请号：US18293128
申请日：2022-07-29
申请人： Spiderwort Inc.
发明人： Andrew E. PELLING , Matthew LOURENCO , Ryan Hickey , Paula Cristina de Sousa Faria Tischer , Anna CANTO , Joshua SALAMUN , Colin RUSSELL
CPC分类号： C12N5/0658 , A23J3/227 , A23L5/49 , A23L13/00 , A23L17/00 , A23L19/09 , C12N5/04 , C12N2513/00 , C12N2533/70 , C12N2533/90 , C12N2537/10
摘要： Disclosed herein is a method of preparing a seeded biomaterial scaffold. The method comprises combining a biomaterial scaffold and a plurality of cells to provide a mixture; and applying a pressure to the mixture to thereby cause the plurality of cells to infiltrate the scaffold, thereby forming the seeded biomaterial scaffold.
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2.发明公开公开(公告)号：US20240318140A1
公开(公告)日：2024-09-26
申请号：US18737151
申请日：2024-06-07
申请人： CELLMEAT CORP.
发明人： Giljun PARK , Heejung KIM , Minsoo LEE , Junhyuk BAE , Jongyoung LIM , Yubin LEE
CPC分类号： C12N5/0658 , A23L13/00 , C12N2533/70 , C12N2533/74 , C12N2533/76 , C12N2533/78 , C12N2533/90
摘要： The present disclosure relates to a scaffold based on microbial-derived bio-cellulose and a manufacturing method thereof, and/or a hydrogel scaffold containing microbial-derived bio-cellulose powder and a manufacturing method thereof. The scaffolds can be usefully used as scaffolds for manufacturing cultured meat due to excellent cell adhesion capability and physical properties.
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公开(公告)号：US20240315294A1
公开(公告)日：2024-09-26
申请号：US18259987
申请日：2021-12-22
申请人： CELL AG TECH INC
发明人： Valentin FULGA , Simon BUBNIC , Elizabeth JOHNSTON , Haidun LIU , Majid EBRAHIMI , Joshua POLLACK , Peter CURRIE
CPC分类号： A23L17/00 , C12N5/0658 , C12N2501/105 , C12N2501/115 , C12N2509/00 , C12N2533/54
摘要： Cultivated seafood muscle cells are produced through a process that first isolates culture initiating cells from tissue using mechanical and enzymatic means and then expanding their number over time in culture. Methods for enhancing yield of seafood muscle cells are used for manufacturing a seafood product.
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公开(公告)号：US12098389B2
公开(公告)日：2024-09-24
申请号：US17844757
申请日：2022-06-21
申请人： KEIO UNIVERSITY
发明人： Minoru Ko
IPC分类号： C12N5/071 , C12N5/077 , C12N5/0793 , C12N15/09 , C12N15/113
CPC分类号： C12N5/0658 , C12N5/0619 , C12N5/067 , C12N15/09 , C12N15/113 , C12N2310/14 , C12N2506/02
摘要： In related-art methods of differentiating pluripotent stem cells into a desired cell type, there has not been established a differentiation induction method using human ES/iPS cells and being highly efficient. Many attempts have been made, including a stepwise differentiation induction method based on the control of culture conditions or the addition of, for example, various cell growth factors/differentiation factors to a culture solution, but the use of complicated culture steps is a big problem. A method of inducing differentiation into a desired cell type within a short period of time and with high efficiency by use of a pluripotent stem cell that actively undergoes cell differentiation, which is obtained by reducing an undifferentiated state of the pluripotent stem cell, has been developed, and thus the present invention has been completed.
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公开(公告)号：US20240306685A1
公开(公告)日：2024-09-19
申请号：US18254827
申请日：2021-11-30
发明人： Shujian Ong
CPC分类号： A23L27/26 , A23J3/227 , A23L27/215 , C12N5/0656 , C12N5/0658
摘要： This invention relates to the extraction of meat-specific flavour compounds from in vitro cultured animal cells of a meat species by heating the cells in fat, such as plant oil. Meat flavourings and methods of production are provided, along with methods of flavouring foodstuffs, such as meat substitute products, and foodstuffs flavoured by these methods.
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公开(公告)号：US20240287460A1
公开(公告)日：2024-08-29
申请号：US18573148
申请日：2022-06-23
CPC分类号： C12N5/0658 , C12N1/12 , C12N5/0025 , C12N2500/05 , C12N2500/32 , C12N2500/34 , C12N2500/38 , C12N2500/76 , C12N2500/90 , C12N2502/70
摘要： The present invention provides a method for producing a composition for culturing animal cells, wherein the method includes: (1) a step in which an algae is mixed with a solid acid catalyst and an algae extract is obtained by heating; and (2) a step in which the algae extract is added to a medium for culturing animal cells and the concentration of the algae extract is adjusted. The present invention also provides a recycling/culturing method for algae and animal cells including: (i) a step in which a waste liquid (a first waste liquid) previously used to culture animal cells is used to culture algae; (ii) a step in which the algae is collected, mixed with a solid catalyst, and heated, and an algae extract is thereby obtained; (iii) a step in which the algae extract is added to the waste liquid (a second waste liquid) previously used to culture algae in (i), the concentration of the algae extract is adjusted, and a composition for culturing animal cells is produced; and (iv) a step in which animal cells are cultured using the composition for culturing animal cells.
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公开(公告)号：US12059479B2
公开(公告)日：2024-08-13
申请号：US17463007
申请日：2021-08-31
申请人： CELLSCRIPT, LLC
发明人： Judith Meis , Anthony Person , Cynthia Chin , Jerome Jendrisak , Gary Dahl
IPC分类号： A61K48/00 , A61K31/7105 , A61K33/06 , A61K38/00 , C12N5/074 , C12N5/077 , C12N5/0793 , C12N15/10 , C12N15/87 , C12P19/34 , C12P19/38 , C12P21/02
CPC分类号： A61K48/0066 , A61K31/7105 , A61K33/06 , A61K38/005 , A61K48/0041 , C12N5/0619 , C12N5/0658 , C12N5/0696 , C12N15/1003 , C12N15/1096 , C12N15/87 , C12P19/34 , C12P19/38 , C12P21/02 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2501/73 , C12N2506/1307 , C12N2510/00 , C12Y301/26003 , A61K33/06 , A61K2300/00 , A61K31/7105 , A61K2300/00
摘要： The present invention relates to compositions, kits and methods for making and using RNA compositions comprising in vitro-synthesized ssRNA inducing a biological or biochemical effect in a mammalian cell or organism into which the RNA composition is repeatedly or continuously introduced. In certain embodiments, the invention provides compositions and methods for changing the state of differentiation or phenotype of a human or other vertebrate cell. For example, the present invention provides mRNA and methods for reprogramming cells that exhibit a first differentiated state or phenotype to cells that exhibit a second differentiated state or phenotype, such as to reprogram human somatic cells to pluripotent stem cells.
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公开(公告)号：US20240240201A1
公开(公告)日：2024-07-18
申请号：US18289516
申请日：2022-05-04
申请人： MOGRIFY LIMITED
IPC分类号： C12N15/86 , C12N5/071 , C12N5/077 , C12N5/0786 , C12N5/0793
CPC分类号： C12N15/86 , C12N5/0619 , C12N5/0645 , C12N5/0658 , C12N5/067 , C12N2506/1307 , C12N2506/45 , C12N2770/36143 , C12N2840/203
摘要： Described herein are methods and compositions containing self-replicating RNA encoding at least one transcription factor and their uses in cell conversion of a pluripotent stem cell. a multipotent stem cell. or a differentiated source cell to a desired target cell. The methods and compositions can be used to transfect human pluripotent or multipotent stem cells and various human somatic cell types with self- replicating RNA to convert cells in vitro, in vivo or ex vivo.
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公开(公告)号：US20240228932A9
公开(公告)日：2024-07-11
申请号：US18546584
申请日：2022-03-29
发明人： Yukiko MIYATAKE , Kaori SHIGETOMI , Hisako TOKUNO , Kotaro DAI , Kei SHINOTSUKA
CPC分类号： C12M25/14 , C12N5/0658 , C12N5/0693 , C12N2533/30 , C12N2535/00 , C12N2539/00
摘要： A cell mass-forming member that is capable of easily forming a cell mass and superior in industrial mass productivity; a culture container equipped with the cell mass-forming member; a method for producing cultured cells using the cell mass-forming member; and cultured cells with a cell mass-forming member that are equipped with the cell mass-forming member. The cell mass-forming member has a base material, an adhesion inhibition area and a cell adhesion area are formed on the surface of the base material; a micro-concavo-convex structure area including a plurality of convex portions is formed in the cell adhesion area; and a hydrophilic coating layer is formed on both the adhesion inhibition area and the cell adhesion area. The culture container and the cultured cells with a cell mass-forming member are equipped with the cell mass-forming member. The method for producing cultured cells includes using the cell mass-forming member.
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公开(公告)号：US20240209321A1
公开(公告)日：2024-06-27
申请号：US18496419
申请日：2023-10-27
IPC分类号： C12N5/071 , C12N5/073 , C12N5/074 , C12N5/077 , C12N5/0775 , C12N5/0797
CPC分类号： C12N5/069 , C12N5/0605 , C12N5/0623 , C12N5/0626 , C12N5/0658 , C12N5/0662 , C12N5/0686 , C12N5/0696 , C12N2501/60 , C12N2503/02 , C12N2506/45 , C12N2510/00
摘要： Forced expression of a handful of transcription factors (TFs) can induce conversions between cell identities; however, the extent to which TFs can alter cell identity has not been systematically assessed. Here, we assembled a human TFome, a comprehensive expression library of 1,578 human TF clones with full coverage of the major TF families. By systematically screening the human TFome, we identified 77 individual TFs that induce loss of human-induced-pluripotent-stem-cell (hiPSC) identity, suggesting a pervasive ability for TFs to alter cell identity. Using large-scale computational cell type classification trained on thousands of tissue expression profiles, we identified cell types generated by these TFs with high efficiency and speed, without additional selections or mechanical perturbations. TF expression in adult human tissues only correlated with some of the cell lineage generated, suggesting more complexity than observation studies can explain.
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