公开(公告)号：US12121539B2

公开(公告)日：2024-10-22

申请号：US15759046

申请日：2016-09-10

申请人： BIOSCEPTRE (AUST) PTY LTD

发明人： Justin Taylor Coombs ,  Simon Charles Barry ,  Timothy John Sadlon

IPC分类号： A61K35/17 ,  C07K14/705 ,  C07K14/715 ,  C07K14/725 ,  C07K14/735 ,  C07K16/28 ,  C12N5/0786 ,  C07K19/00

CPC分类号： A61K35/17 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70535 ,  C07K14/70578 ,  C07K14/715 ,  C07K16/28 ,  C12N5/0645 ,  C07K19/00 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30 ,  C07K2319/33 ,  C07K2319/60

摘要： The present invention relates to chimeric antigen receptors (CARs) directed to cells expressing a dysfunctional or non-functional P2X purinoceptor 7 receptor. Further provided are methods of targeting neoplastic cells and tumours expressing a dysfunctional or non-functional P2X purinoceptor 7 receptor and methods of treating and preventing cancer is a subject.

公开(公告)号：US20240335471A1

公开(公告)日：2024-10-10

申请号：US18294039

申请日：2022-08-01

申请人： A2 Biotherapeutics, Inc.

发明人： Agnes Hamburger ,  Jee Young Mock ,  Mark Daris

IPC分类号： A61K35/17 ,  A61K39/00 ,  C12N5/0781 ,  C12N5/0783 ,  C12N5/0786 ,  C12N15/86

CPC分类号： A61K35/17 ,  A61K39/4631 ,  A61K39/4632 ,  A61K39/464411 ,  C12N5/0635 ,  C12N5/0636 ,  C12N5/0645 ,  C12N5/0646 ,  C12N15/86 ,  A61K2239/13 ,  A61K2239/17 ,  A61K2239/21 ,  A61K2239/22 ,  C12N2740/15043 ,  C12N2750/14143

摘要： The disclosure relates to a dual vector system with a first vector comprising a sequence encoding an inhibitory receptor and a sequence encoding a first part of an activator receptor; and a second vector, comprising a sequence encoding a second part of the activator receptor.

公开(公告)号：US20240329033A1

公开(公告)日：2024-10-03

申请号：US18515636

申请日：2023-11-21

申请人： Temple University-Of The Commonwealth System of Higher Education

发明人： Jay Rappaport ,  Sarah Vakili

IPC分类号： G01N33/50 ,  C07K14/705 ,  C07K14/73 ,  C07K14/735 ,  C12N5/0786

CPC分类号： G01N33/5047 ,  C07K14/70514 ,  C07K14/70535 ,  C07K14/70596 ,  C12N5/0645 ,  C12N2501/052 ,  C12N2501/22 ,  C12N2501/24 ,  C12N2501/25 ,  C12N2501/30 ,  C12N2501/39 ,  C12N2501/999

摘要： The invention provides monocytes expressing CD16 and CD163 and experimental system for drug screening or evaluating drug candidates where the modulation of CD16 and CD163 is desired.

公开(公告)号：US20240287462A1

公开(公告)日：2024-08-29

申请号：US18624848

申请日：2024-04-02

申请人： Wisconsin Alumni Research Foundation

发明人： Peiman HEMATTI ,  John KINK ,  Christian CAPITINI ,  Matthew FORSBERG ,  Nicholas HESS ,  Zachary ROSENKRANS ,  Reinier Hernandez

IPC分类号： C12N5/0775 ,  A61K35/15 ,  A61K35/35 ,  C12N5/0786

CPC分类号： C12N5/0668 ,  A61K35/15 ,  A61K35/35 ,  C12N5/0645 ,  C12N2500/84 ,  C12N2502/1323 ,  C12N2502/1358

摘要： The disclosure relates to populations of educated macrophages and monocytes generated ex vivo or in vivo, and methods of making and using the same using lipid A aminoalkyl glucosaminide phosphate molecules, such as CRX molecules or extracellular vesicles (EVs) from mesenchymal stromal cells (MSC) stimulated with CRX molecules. Also described are EVs and methods for making and using the same from MSCs exposed to CRX.

公开(公告)号：US20240279352A1

公开(公告)日：2024-08-22

申请号：US18644720

申请日：2024-04-24

申请人： OSE IMMUNOTHERAPEUTICS

发明人： Nicolas Poirier ,  Bernard Vanhove ,  Vanessa Gauttier

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C12N5/0786 ,  C12N15/113

CPC分类号： C07K16/2896 ,  A61P35/00 ,  C07K16/2803 ,  C07K16/2827 ,  C07K16/2878 ,  C12N5/0645 ,  C12N15/1138 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/76 ,  C12N2310/14 ,  C12N2320/31

摘要： The present invention concerns the use of an anti-SIRPa compound able to inhibit the polarization of anti-inflammatory M2-type macrophages and/or favors pro-inflammatory M1-type macrophages. In a preferred embodiment, such compound is used to treat cancer. Interestingly, this invention allows to treat cancer through an indirect pathway involving the immune system.

公开(公告)号：US20240269282A1

公开(公告)日：2024-08-15

申请号：US18290153

申请日：2022-05-10

申请人： Institut Curie ,  INSERM (Institut National de la Santé et de la Recherche Médicale)

发明人： Clotilde Thery ,  Mercedes Tkach

IPC分类号： A61K39/00 ,  A61K9/50 ,  A61P35/00 ,  C07K14/725 ,  C07K16/30 ,  C12N5/0786

CPC分类号： A61K39/4614 ,  A61K9/5068 ,  A61K39/4631 ,  A61K39/4644 ,  A61P35/00 ,  C07K14/7051 ,  C07K16/30 ,  C12N5/0645 ,  C12N2510/00

摘要： The invention relates to methods and pharmaceutical compositions for the treatment and diagnosis of cancer. The invention also relates to methods and pharmaceutical compositions for the treatment of inflammatory diseases and autoimmune diseases. The inventors investigate the role and specific contribution of extracellular vesicles (EVs) in cancer environment. The inventors demonstrate that CSF1-associated EVs induce macrophage signature associated with T cell infiltration and extended patient survival. The inventors demonstrate that via specific extracellular vesicles, these tumors promote pro-inflammatory macrophages correlated with better clinical outcome and a better prognosis in TNBC patients. In the present invention, the inventors provide in vitro evidences towards a direct role of CSF1-associated EVs as tools, alone or with other immuno-therapies, to promote anti-tumor immune responses. Thus, the present invention relates to CSF1-associated EVs, their use in the treatment and diagnosis of cancer, and their targeting in the treatment of inflammatory diseases and autoimmune diseases.

公开(公告)号：US11999992B2

公开(公告)日：2024-06-04

申请号：US16130634

申请日：2018-09-13

申请人： Berkeley Lights, Inc.

发明人： Jason M. McEwen

IPC分类号： C12Q1/6806 ,  B01L3/00 ,  C12N5/0781 ,  C12N5/0783 ,  C12N5/0786 ,  C12Q1/686

CPC分类号： C12Q1/6806 ,  B01L3/5027 ,  C12N5/0635 ,  C12N5/0636 ,  C12N5/0645 ,  C12N5/0646 ,  C12Q1/686 ,  C12Q1/6806 ,  C12Q2527/125

摘要： Reagents for stabilizing the nucleic acids of a biological cell, compositions, kits and methods of use thereof are described. The stabilization reagents may prepare the nucleic acids within the biological cell for storage and preserve the representative population of the nucleic acids for later isolation and analysis.

公开(公告)号：US20240150716A1

公开(公告)日：2024-05-09

申请号：US18550232

申请日：2022-03-18

申请人： HEMERA S.R.L. ,  HUMANITAS MIRASOLE S.P.A.

发明人： Ilaria DECIMO ,  Francesco BIFARI ,  Sissi DOLCI ,  Guido Francesco FUMAGALLI ,  Massimo LOCATI

IPC分类号： C12N5/0786 ,  A61K35/15 ,  A61P25/00

CPC分类号： C12N5/0645 ,  A61K35/15 ,  A61P25/00 ,  C12N2500/02 ,  C12N2501/22 ,  C12N2502/30

摘要： The present invention relates to an in vitro or ex vivo method for inducing a phenotypic and/or functional change in a population of mononuclear phagocytes isolated from biological samples. The method includes the incubation of the population in a culture medium which includes factors released from tumor cultures or explants. The incubation takes place under hypoxic conditions and the incubation induces a phenotypic and/or functional change in the mononuclear phagocytes of the population. The macrophages thus obtained assume a unique regenerative phenotype not present in other polarized phenotypes, including M2 macrophages. In addition, the invention relates to the use of the bioreactor thus produced for the regeneration of tissues, including neural tissue.

公开(公告)号：US20240139240A1

公开(公告)日：2024-05-02

申请号：US18384625

申请日：2023-10-27

申请人： DREXEL UNIVERSITY

发明人： Seena K. Ajit

IPC分类号： A61K35/15 ,  A61K9/00 ,  A61K45/06 ,  A61P25/04 ,  C12N5/0786

CPC分类号： A61K35/15 ,  A61K9/0019 ,  A61K45/06 ,  A61P25/04 ,  C12N5/0645

摘要： Described herein is a method of treating, ameliorating, and/or preventing post-operative pain in a subject using certain compositions recited in the disclosure. The method comprises administering to the subject a therapeutically effective of a composition comprising a small extracellular vesicle (sEV) or an exosome released by a macrophage. Also described herein is a method of performing surgical operation. The method comprises performing a surgery on the subject, as well as administering to the subject the composition comprising the sEV or exosome herein.

公开(公告)号：US11946071B2

公开(公告)日：2024-04-02

申请号：US16641137

申请日：2018-08-23

申请人： UNIVERSITÄT ZÜRICH

发明人： Simon Hoerstrup ,  Benedikt Weber ,  Anna Mallone

IPC分类号： C12N5/0784 ,  C12N5/071 ,  C12N5/077 ,  C12N5/0786 ,  C12Q1/6883 ,  G01N33/68

CPC分类号： C12N5/0645 ,  C12N5/0639 ,  C12N5/0656 ,  C12N5/0697 ,  C12Q1/6883 ,  G01N33/6893 ,  C12N2500/34 ,  C12N2501/727 ,  C12N2502/1323 ,  C12N2513/00

摘要： The invention provides a method for the generation of a layered cellular 3 D microtissue aggregate, comprising the steps of contacting myeloid cells with a protein kinase C agonist, yielding primed myeloid cells; incubating the primed myeloid cells in the presence of LDL in a confined volume, particularly in a hanging drop culture; yielding a 3 D culture of myeloid cells; and incubating the 3 D culture together with fibroblasts in a hanging drop in the presence of LDL, yielding the layered cellular aggregate.