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1.发明公开公开(公告)号：US20240360209A1
公开(公告)日：2024-10-31
申请号：US18623647
申请日：2024-04-01
发明人： Bongcheol KIM , Wonkyum KIM , Jeongwon YOON , Junho CHUNG , Junyeong JIN , Eunhwoi YOU
IPC分类号： C07K16/24 , A61K39/00 , A61K39/395 , A61K45/06 , A61K47/68 , A61P25/00 , A61P25/02 , A61P29/00 , A61P35/00
CPC分类号： C07K16/24 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61P25/00 , A61P25/02 , A61P29/00 , A61P35/00 , A61K2039/505 , C07K2317/33 , C07K2317/41 , C07K2317/565 , C07K2317/622 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/74 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. In a specific aspect, antibodies are deimmunized to reduce immunogenicity in a human subject. In some embodiments, the anti-FAM19A5 antibodies can modulate FAM19A5 activity, e.g., inhibit, suppress, reduce, or reverse the onset of reactive gliosis and/or excessive proliferation of reactive astrocytes, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as central nervous system damage, a degenerative brain disorder, a neuropathic pain, or a cancer, by administering an antibody that specifically binds to human FAM19A5.
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公开(公告)号：US12121609B2
公开(公告)日：2024-10-22
申请号：US17079498
申请日：2020-10-25
发明人： Vladimir Coric , Robert Berman , Ronald S. Vladyka , Amgad Saleh , Danny Yu
IPC分类号： A61K31/428 , A61K9/00 , A61K9/08 , A61K9/20 , A61K47/20 , A61K47/26 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30
CPC分类号： A61K9/006 , A61K9/0056 , A61K9/08 , A61K9/20 , A61K31/428 , A61K47/20 , A61K47/26 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30
摘要： Disclosed is sublingual administration of riluzole. In particular, a method for treating a neuropsychiatric disorder or symptom by administering a sublingual formulation of riluzole is provided. In addition, a method of relieving or reducing oral pain using the sublingual formulation of riluzole is disclosed.
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公开(公告)号：US12121513B2
公开(公告)日：2024-10-22
申请号：US18320761
申请日：2023-05-19
申请人： IntraBio Ltd.
发明人： Michael Strupp
IPC分类号： A61K31/4402 , A61K9/00 , A61K31/137 , A61P25/00
CPC分类号： A61K31/4402 , A61K9/0053 , A61K31/137 , A61P25/00
摘要： A first aspect of the invention relates to betahistine, or a pharmaceutically acceptable salt thereof, and a monoamine oxidase inhibitor, for use in the treatment or prevention of one or more symptoms of vertigo in a subject.
A second aspect of the invention relates to a method of treating or preventing one or more symptoms of vertigo in a subject, said method comprising administering to the subject (i) betahistine, or a pharmaceutically acceptable salt thereof, and (ii) a monoamine oxidase inhibitor.-
公开(公告)号：US20240325488A1
公开(公告)日：2024-10-03
申请号：US18636898
申请日：2024-04-16
发明人： Gong CHEN
CPC分类号： A61K38/1703 , A61K9/0085 , A61P25/00 , A61K48/00
摘要： This document provides methods and materials involved in treating mammals having had a hemorrhagic stroke. For example, methods and materials for administering a composition containing exogenous nucleic acid encoding a NeuroD1 polypeptide and exogenous nucleic acid encoding a Dlx2 polypeptide to a mammal having had a hemorrhagic stroke are provided.
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公开(公告)号：US20240325453A1
公开(公告)日：2024-10-03
申请号：US18620565
申请日：2024-03-28
CPC分类号： A61K35/30 , A61P25/00 , C12N5/0622 , C12N15/635 , C12N2510/00
摘要： Compositions and methods for administering Doxycycline-activatable cells for repair of the nervous system after injury or disease are contemplated herein.
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公开(公告)号：US12104159B2
公开(公告)日：2024-10-01
申请号：US17808247
申请日：2022-06-22
IPC分类号： C07H21/02 , A61P25/00 , C12N15/113
CPC分类号： C12N15/1137 , A61P25/00 , C12N2310/11 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2320/32
摘要： The present invention relates to PIKFYVE antisense oligonucleotides (ASOs), pharmaceutical compositions containing them, and methods for treating, inhibiting, suppressing, and preventing neurological diseases with them.
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公开(公告)号：US12102618B2
公开(公告)日：2024-10-01
申请号：US18353840
申请日：2023-07-17
IPC分类号： A61K31/428 , A61P25/00 , A61K9/20 , A61K9/48
CPC分类号： A61K31/428 , A61P25/00 , A61K9/20 , A61K9/48
摘要： Disclosed are methods of treating ataxia by administering to a patient in need thereof a riluzole prodrug such as troriluzole. Pharmaceutical compositions and kits including the riluzole prodrugs are also disclosed.
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公开(公告)号：US20240316151A1
公开(公告)日：2024-09-26
申请号：US18579591
申请日：2022-12-27
发明人： Zhen Wang , Dongdong Shi , Yingdan Zhang
CPC分类号： A61K38/1754 , A61P25/00
摘要： The present invention relates to a use of insulin-like growth factor binding protein 2 in a preparation of drugs for treating neurological demyelinating diseases. IGFBP2 intervention can significantly increase myelination levels and improve psychiatric symptoms caused by stress demyelination.
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9.发明公开公开(公告)号：US20240316128A1
公开(公告)日：2024-09-26
申请号：US18427867
申请日：2024-01-31
IPC分类号： A61K35/747 , A61K31/198 , A61K35/742 , A61K35/745 , A61P25/00
CPC分类号： A61K35/747 , A61K31/198 , A61K35/742 , A61K35/745 , A61P25/00
摘要： The current invention discloses the use of a multi-strain probiotic formulation comprising one or more novel Lactobacilli, Bifidobacterium and Bacillus strains for the alleviation, prevention and treatment of obsessive-compulsive disorder and/or obsessive-compulsive disorder like symptoms. The multi-strain probiotic formulation disclosed herein for use as treatment for obsessive-compulsive disorder symptoms comprises Bacillus coagulans Unique IS-2, Lactobacillus plantarum UBLP-40, Lactobacillus rhamnosus UBLR-58, Bifidobacterium lactis UBBLa-70, Bifidobacterium breve UBBr-01, and Bifidobacterium infantis UBBI-01.
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公开(公告)号：US12097180B2
公开(公告)日：2024-09-24
申请号：US17027057
申请日：2020-09-21
发明人： John J. McGlone
IPC分类号： A61K31/404 , A61K9/00 , A61K31/20 , A61P25/00 , A61P43/00
CPC分类号： A61K31/404 , A61K9/0056 , A61K31/20 , A61P25/00 , A61P43/00
摘要： Provided herein are maternal neonatal pheromonal agents capable of reducing aggression and improving feeding behavior in a pig. Compositions comprising the pheromonal agents and methods of using the agents to reduce aggression and improve feeding behavior and weight gain in the pig are also provided.
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