公开(公告)号：US12104159B2

公开(公告)日：2024-10-01

申请号：US17808247

申请日：2022-06-22

Applicant: AcuraStem Incorporated

Inventor： Wen-Hsuan Chang ,  Emily Elizabeth Lee

IPC: C07H21/02 ,  A61P25/00 ,  C12N15/113

CPC classification number: C12N15/1137 ,  A61P25/00 ,  C12N2310/11 ,  C12N2310/31 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346 ,  C12N2320/32

Abstract: The present invention relates to PIKFYVE antisense oligonucleotides (ASOs), pharmaceutical compositions containing them, and methods for treating, inhibiting, suppressing, and preventing neurological diseases with them.

公开(公告)号：US20240401052A1

公开(公告)日：2024-12-05

申请号：US18807343

申请日：2024-08-16

Applicant: AcuraStem Incorporated

Inventor： Wen-Hsuan CHANG ,  Justin K. ICHIDA

IPC: C12N15/113 ,  A61P25/28

Abstract: The present invention relates to UNC13A cryptic exon antisense oligonucleotides (ASOs), pharmaceutical compositions containing them, and methods for treating, inhibiting, suppressing, and preventing neurological diseases with them.

公开(公告)号：US20230135152A1

公开(公告)日：2023-05-04

申请号：US17760384

申请日：2021-02-11

Applicant: ACURASTEM INCORPORATED

Inventor： Martin SMRCINA ,  Ronghua LI ,  Anil NAIR ,  Paul AUGUST ,  Kirsten BJERGARDE ,  Jennifer LUDINGTON

IPC: C07D403/14 ,  C07D491/048 ,  C07D405/14 ,  C07D417/14 ,  C07D401/14 ,  C07D413/14 ,  C07D487/04 ,  C07D473/18 ,  C07D473/34 ,  C07D239/48 ,  C07D475/06 ,  C07D471/04 ,  C07D498/08

Abstract: The present invention relates to compounds useful as inhibitors of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) as well as their use for treating diseases and disorders associated with PIKfyve.

公开(公告)号：US20210033597A1

公开(公告)日：2021-02-04

申请号：US16732109

申请日：2019-12-31

Applicant: AcuraStem Incorporated

Inventor： Justin K. Ichida ,  Hongyan Zhou ,  Wen-Hsuan Chang ,  Samuel V. Alworth

IPC: G01N33/50 ,  C12N5/0793

Abstract: The present invention relates to systems and methods for reprogramming cells to generate neurons and identifying effective treatments for neurodegenerative disorders using such neurons, as well as systems and methods for treating and developing treatments for one or more neurodegenerative disorders.

公开(公告)号：US20240352026A1

公开(公告)日：2024-10-24

申请号：US18612147

申请日：2024-03-21

Applicant: AcuraStem Incorporated

Inventor： Martin SMRCINA ,  Ronghua LI ,  Anil NAIR ,  Paul August ,  Kirsten BJERGARDE

IPC: C07D491/048 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D491/048 ,  C07D405/14 ,  C07D413/14

Abstract: The present invention relates to compounds of formula (I) (shown below) useful as inhibitors of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) as well as their use for treating diseases and disorders associated with PIKfyve.