公开(公告)号：US20230253625A1

公开(公告)日：2023-08-10

申请号：US18135365

申请日：2023-04-17

Applicant: SK ON CO., LTD.

Inventor： In Haeng Cho ,  Dong Gun Lee ,  Joo Hyun Lee ,  Sung Jin Kim

IPC: H01M10/0567 ,  C07C309/67 ,  C07F9/06 ,  H01M10/0525 ,  H01M10/0568 ,  H01M10/0569

CPC classification number: H01M10/0567 ,  C07C309/67 ,  C07F9/062 ,  H01M10/0525 ,  H01M10/0568 ,  H01M10/0569 ,  H01M2300/0025

Abstract: An electrolyte for a lithium secondary battery according to exemplary embodiments of the present inventing includes an organic solvent, a lithium salt, a first additive represented by a predetermined chemical formula, and a second additive represented by a predetermined chemical formula. A protective film is formed by the additives to suppress an expansion of a lithium secondary battery and improve storage property at high temperature.

公开(公告)号：US20200335822A1

公开(公告)日：2020-10-22

申请号：US16606972

申请日：2018-08-24

Applicant: LG Chem, Ltd.

Inventor： Sung Hoon Yu ,  Chul Haeng Lee ,  Hyun Seung Kim

IPC: H01M10/0567 ,  H01M10/0568 ,  H01M10/0525 ,  C07C69/96 ,  C07C309/67 ,  C07C305/18 ,  C07C305/14

Abstract: A non-aqueous electrolyte solution for a lithium secondary battery and a lithium secondary battery including the same are disclosed herein. In some embodiments, a non-aqueous electrolyte solution for a lithium secondary battery, includes an additive having metal ion adsorbability and capable of forming a stable ion conductive film on the surface of an electrode. In some embodiments, a lithium secondary battery including the same has an improved an abnormal voltage drop phenomenon.

公开(公告)号：US10241399B2

公开(公告)日：2019-03-26

申请号：US14937308

申请日：2015-11-10

Applicant: BASF SE

Inventor： Kazuhiko Kunimoto ,  Kaori Sameshima ,  Yuki Matsuoka ,  Hisatoshi Kura

IPC: C07C309/00 ,  G03F7/00 ,  G02B5/22 ,  C07D327/06 ,  C07C309/30 ,  C07C327/58 ,  C07D265/32 ,  C07D277/54 ,  C07D291/02 ,  C07D213/59 ,  C07C327/60 ,  C07D279/12 ,  C07D307/10 ,  C07D309/08 ,  G03F7/029 ,  G03F7/031 ,  G03F7/32 ,  C08F220/10 ,  C07C309/67 ,  C07C309/73 ,  C07D213/78 ,  C07D295/04 ,  G02B5/20

Abstract: The present invention relates to a polymerizable composition comprising at least one ethylenically unsaturated, polymerizable compound and at least one oxime sulfonate compound of the formula I QAaBbCc  (I) where a is 0, 1, 2, 3, 4 or 6, b is 0, 1, 2, 3, 4 or 6, and c is 0, 1, 2, 3, 4 or 6, where the sum of a+b+c is 1, 2, 3, 4 or 6 where A is a group B is a group C is a group where # denotes the point of attachment to Q; X is S or NR14 and Q, R1, R2, R3 and R14 are as defined in claim 1 and in the description. The present invention also relates to the use of the this composition, to novel oxime sulfonates and the use of the oxime sulfonates as thermal curing promoter.

公开(公告)号：US09085567B2

公开(公告)日：2015-07-21

申请号：US14178982

申请日：2014-02-12

Applicant: Allergan, Inc.

Inventor： Jose L. Martos ,  William R. Carling ,  David F. Woodward ,  Jenny W. Wang ,  Jussi J. Kangasmetsa

IPC: C07D413/04 ,  C07D413/14 ,  C07C65/30 ,  C07C237/06 ,  C07C271/20 ,  C07C309/67 ,  C07D207/16 ,  C07D317/46

CPC classification number: C07D413/04 ,  C07C65/30 ,  C07C237/06 ,  C07C271/20 ,  C07C309/67 ,  C07D207/16 ,  C07D317/46 ,  C07D413/14

Abstract: The present invention provides compounds, that are N-alkyl-2-(1-(5-substituted-2-(3-oxo-3-(trifluoromethylsulfonamido)propyl)benzyl)pyrrolidin-2-yl)oxazole-4-carboxamide wherein the 5 substituent is selected from the group consisting of halo and alkyloxy radicals. The compound may be represented by the following formula wherein R1 is selected from the group consisting of CO2R7 and CON(R7)SO2R7 wherein R1, R2, R3, R4, and R7 are as defined in the specification. The compounds may be administered to treat DP1, FP, EP1, EP3, TP and/or EP4 receptor mediated diseases or conditions.

Abstract translation: 本发明提供了N-烷基-2-（1-（5-取代-2-（3-氧代-3-（三氟甲基磺酰胺基）丙基）苄基）吡咯烷-2-基）恶唑-4-甲酰胺其中 5取代基选自卤代和烷氧基。 化合物可以由下式表示，其中R 1选自CO 2 R 7和CON（R 7）SO 2 R 7，其中R 1，R 2，R 3，R 4和R 7如说明书中所定义。 可以施用化合物以治疗DP1，FP，EP1，EP3，TP和/或EP4受体介导的疾病或病症。

公开(公告)号：US09012678B2

公开(公告)日：2015-04-21

申请号：US13818791

申请日：2011-08-25

Applicant: Shriprakash Dhar Dwivedi ,  Ashok Prasad ,  Kuldeep Natwarlal Jain

Inventor： Shriprakash Dhar Dwivedi ,  Ashok Prasad ,  Kuldeep Natwarlal Jain

IPC: C07C69/76 ,  C07C219/28 ,  C07C41/26 ,  C07C51/43 ,  C07C59/56 ,  C07C67/03 ,  C07C213/10 ,  C07C217/62 ,  C07C309/66 ,  C07C213/00 ,  C07C213/06 ,  C07C213/08 ,  C07C303/28 ,  C07C309/67

CPC classification number: C07C219/28 ,  C07B2200/07 ,  C07B2200/13 ,  C07C41/26 ,  C07C51/43 ,  C07C59/56 ,  C07C67/03 ,  C07C213/00 ,  C07C213/06 ,  C07C213/08 ,  C07C213/10 ,  C07C217/62 ,  C07C303/28 ,  C07C309/66 ,  C07C309/67 ,  C07C215/54 ,  C07C43/23 ,  C07C69/734

Abstract: The invention relates to improved process for the preparation of fesoterodine and its pharmaceutically acceptable salt, specifically fesoterodine fumarate of formula (1). The invention relates to solid state forms of a novel salt of fesoterodine and process for the preparation thereof. The invention also relates to highly pure fesoterodine fumarate substantially free of impurity X at RRT 1.37. The invention also provides solid particles of pure fesoterodine fumarate wherein 90 volume-percent of the particles (D90) have a size of higher than 200 microns.

Abstract translation: 本发明涉及制备非索特罗及其药学上可接受的盐，特别是式（1）的富马酸弗索塔罗汀的改进方法。 本发明涉及非索罗定新型盐的固态形式及其制备方法。 本发明还涉及在RRT 1.37基本上不含杂质X的高纯度富马酸菲索特罗。 本发明还提供富马酸纯的富特罗定的固体颗粒，其中90体积％的颗粒（D90）具有高于200微米的尺寸。

公开(公告)号：US20050234123A1

公开(公告)日：2005-10-20

申请号：US10497012

申请日：2002-11-26

Applicant: Aldo Belli ,  Vincenzo Cannata ,  Telly Fonduca ,  Martin Hedberg ,  Andreas Westermark ,  Marco Villa

Inventor： Aldo Belli ,  Vincenzo Cannata ,  Telly Fonduca ,  Martin Hedberg ,  Andreas Westermark ,  Marco Villa

IPC: A61K31/21 ,  A61K31/216 ,  A61P29/00 ,  C07B61/00 ,  C07C67/08 ,  C07C67/58 ,  C07C201/02 ,  C07C203/04 ,  C07C301/00 ,  C07C303/28 ,  C07C309/66 ,  C07C309/67 ,  C07C309/73 ,  C07C23/02

CPC classification number: C07C309/73 ,  A61K31/21 ,  C07C67/08 ,  C07C67/58 ,  C07C201/02 ,  C07C303/28 ,  C07C309/66 ,  C07C309/67 ,  C07C69/734 ,  C07C203/04

Abstract: At the present invention relates to a new process for the preparation of the (S)-naproxen 4-nitrooxybutyl ester and to new intermediates obtained and used therein. The invention further relates to the use of the new intermediates for the manufacturing of pharmaceutically active compounds such as (S)-naproxen 4-nitrooxybutyl ester. The invention also relates to the use of (S)-naproxen 4-nitrooxybutyl ester prepared according to the process of the present invention for the manufacturing of a medicament for the treatment of pain.

Abstract translation: 本发明涉及制备（S） - 萘普生4-硝基氧丁基酯的新方法及其中获得和使用的新中间体。 本发明还涉及新中间体用于制备药学活性化合物如（S） - 萘普生4-硝基氧基丁基酯的用途。 本发明还涉及根据本发明的方法制备的（S） - 萘普生4-硝基氧基丁基酯在制备用于治疗疼痛的药物中的用途。

公开(公告)号：US06900231B2

公开(公告)日：2005-05-31

申请号：US10262871

申请日：2002-10-03

Applicant: Wenxi Pan ,  Tianbao Lu ,  Thomas P. Markotan ,  Bruce E. Tomczuk

Inventor： Wenxi Pan ,  Tianbao Lu ,  Thomas P. Markotan ,  Bruce E. Tomczuk

IPC: A61K31/155 ,  A61K31/165 ,  A61K31/18 ,  A61K31/255 ,  A61K31/44 ,  A61K45/00 ,  A61L31/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P29/00 ,  A61P43/00 ,  C07C279/00 ,  C07C279/04 ,  C07C291/02 ,  C07C309/67 ,  C07C309/73 ,  C07C311/13 ,  C07C311/21 ,  C07D213/73 ,  C07D213/75 ,  C07D213/64 ,  C07D213/74

CPC classification number: C07D213/73 ,  A61K31/155 ,  A61K31/44 ,  C07C279/00 ,  C07C309/73 ,  C07C311/13 ,  C07C311/21 ,  C07D213/75 ,  A61K2300/00

Abstract: Phenyl acetamide compounds are described, including compounds of or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R3-R6, R11, B, Y and W are set forth in the specification. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as thrombin and factor Xa. Compositions for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation are described. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents. Additionally, the compounds can be detectably labeled and employed for in vivo imaging of thrombi.

Abstract translation: 描述了苯基乙酰胺化合物，包括其溶剂合物，水合物或其药学上可接受的盐的化合物; 其中R 3，R 6，R 11，B，Y和W在说明书中列出。 本发明的化合物是蛋白酶的有效抑制剂，特别是胰蛋白酶样的丝氨酸蛋白酶，如凝血酶和因子Xa。 描述了抑制血小板损失，抑制血小板聚集体形成，抑制纤维蛋白形成，抑制血栓形成和抑制栓塞形成的组合物。 本发明化合物的其它用途是作为凝血剂或者物理上连接于用于血液收集，血液循环和血液储存（例如导管，血液透析机，采血注射器和管）中使用的装置的制造中使用的材料的抗凝剂， 血线和支架。 另外，化合物可以被可检测地标记并用于血栓的体内成像。

公开(公告)号：US5600035A

公开(公告)日：1997-02-04

申请号：US274614

申请日：1994-07-13

Applicant: Charles F. Kahle, II ,  Neil D. McMurdie ,  Raphael O. Kollah ,  Daniel E. Rardon ,  Gregory J. McCollum

Inventor： Charles F. Kahle, II ,  Neil D. McMurdie ,  Raphael O. Kollah ,  Daniel E. Rardon ,  Gregory J. McCollum

IPC: C07C201/08 ,  A61K9/00 ,  A61K9/32 ,  C07C201/12 ,  C07C205/11 ,  C07C205/19 ,  C07C205/23 ,  C07C205/26 ,  C07C205/34 ,  C07C205/42 ,  C07C215/14 ,  C07C271/08 ,  C07C301/00 ,  C07C309/67 ,  C07C309/73 ,  C07C319/14 ,  C07C323/16 ,  C07C323/25 ,  C07C323/29 ,  C08G18/38 ,  C08G59/50 ,  C08G63/685 ,  C08L101/00 ,  C09D163/00 ,  G03F7/00 ,  G03F7/004 ,  G03F7/039 ,  G03F7/16 ,  C07C205/00

CPC classification number: C07C323/25 ,  A61K9/0004 ,  C07C205/11 ,  C07C205/19 ,  C07C205/26 ,  C07C215/14 ,  C08G18/384 ,  C08G59/50 ,  C08G59/504 ,  C08G63/6856 ,  C09D163/00 ,  G03F7/0045 ,  G03F7/039 ,  G03F7/164

Abstract: Photoreactive compounds are synthesized from 2,5- or 2,6-dintrobenzyl groups. Also disclosed are methods of synthesizing reactive monomers containing 2,5- or 2,6-dintrobenzyl groups.

Abstract translation: 光反应性化合物由2,5-或2,6-二苯甲基合成。 还公开了合成含有2,5-或2,6-二苯甲基的反应性单体的方法。

公开(公告)号：US5191069A

公开(公告)日：1993-03-02

申请号：US694386

申请日：1991-05-01

Applicant: Horst Roeschert ,  Georg Pawlowski ,  Hans-Joachim Merrem ,  Ralph Dammel

Inventor： Horst Roeschert ,  Georg Pawlowski ,  Hans-Joachim Merrem ,  Ralph Dammel

IPC: C07C303/30 ,  C07C309/65 ,  C07C309/67 ,  C07C309/73 ,  C07C309/76 ,  C07C309/77 ,  C07C315/04 ,  C07C317/04 ,  C07D209/48 ,  C07D251/32 ,  C07D251/34 ,  C07D333/20 ,  C07D333/34 ,  C07D521/00 ,  G03F7/016

CPC classification number: C07D209/48 ,  C07C309/65 ,  C07C309/67 ,  C07C309/73 ,  C07C309/77 ,  C07D251/32 ,  C07D333/34 ,  G03F7/0163 ,  C07C2101/14 ,  C07C2103/74

Abstract: Polyfunctional compounds containing .alpha.-diazo-.beta.-keto ester units and sulfonate units are disclosed. The polyfunctional compounds have high sensitivity in the deep UV and high thermal stability. Processes for producing the compounds are disclosed. A preferred process first synthesizes .beta.-ketoester/sulfonate precursors and then uses diazo transfer to convert the precursors into the novel compounds. Radiation-sensitive mixtures containing the compounds are also disclosed.

Abstract translation: 公开了含有α-重氮基 - β-酮酯单元和磺酸酯单元的多官能化合物。 多官能化合物在深紫外线和高热稳定性方面具有高灵敏度。 公开了用于生产化合物的方法。 优选的方法首先合成β-酮酯/磺酸盐前体，然后使用重氮转移将前体转化为新化合物。 还公开了含有这些化合物的辐射敏感性混合物。

公开(公告)号：US4150049A

公开(公告)日：1979-04-17

申请号：US855018

申请日：1977-11-22

Applicant: Show-Chu Wong ,  Elliott Shaw

Inventor： Show-Chu Wong ,  Elliott Shaw

IPC: C07C309/67 ,  C07C309/69 ,  C07C309/70 ,  C07C143/68

CPC classification number: C07C309/67 ,  C07C309/69 ,  C07C309/70

Abstract: Novel esters of aromatic sulfonic acids are disclosed. The specific esters are nitrophenyl p- and m-amidinophenylmethanesulfonate. Also disclosed is a method for specific inactivation of the enzyme, thrombin, employing nitrophenyl p-amidinophenylmethanesulfonate.

Abstract translation: 公开了芳族磺酸的新型酯。 特定的酯是对硝基苯基和间 - 脒基苯基甲磺酸酯。 还公开了使用对氨基苯基甲磺酸硝基苯酯特异性灭活酶，凝血酶的方法。