公开(公告)号：US20240208922A1

公开(公告)日：2024-06-27

申请号：US18287136

申请日：2022-04-12

申请人： Studiengesellschaft Kohle gGmbH

发明人： Tobias RITTER ,  Andreas HAERING

IPC分类号： C07D339/08 ,  C07C17/32 ,  C07C41/22 ,  C07C67/30 ,  C07C67/475 ,  C07C231/12 ,  C07C269/06 ,  C07C303/40 ,  C07C319/14 ,  C07D209/48 ,  C07D215/12 ,  C07D215/36 ,  C07D277/74 ,  C07D333/54 ,  C07D453/04 ,  C07D473/12 ,  C07D493/14 ,  C07H15/02 ,  C07J1/00 ,  C07J9/00

CPC分类号： C07D339/08 ,  C07C17/32 ,  C07C41/22 ,  C07C67/30 ,  C07C67/475 ,  C07C231/12 ,  C07C269/06 ,  C07C303/40 ,  C07C319/14 ,  C07D209/48 ,  C07D215/12 ,  C07D215/36 ,  C07D277/74 ,  C07D333/54 ,  C07D453/04 ,  C07D473/12 ,  C07D493/14 ,  C07H15/02 ,  C07J1/0011 ,  C07J9/005

摘要： The present inventions refers a novel trifluoromethyl thianthrenium compound referred to as TT-CF3+X−, a process for preparing the same and the use thereof for trifluoromethylating organic compounds.

公开(公告)号：US20230130823A1

公开(公告)日：2023-04-27

申请号：US17771124

申请日：2020-10-23

申请人： ANHANGUERA EDUCACIONAL PARTICIPAÇÕES S/A ,  FUNDAÇÃO UNIVERSIDADE FEDERAL DO ABC ,  INSTITUTO BUTANTAN

发明人： Anderson ORZARI RIBEIRO ,  Carolina PASSARELLI GONÇALVES ,  Durvanei AUGUSTO MARIA ,  José Agustín QUINCOCES SUÁREZ ,  Manuel SALUSTIANO ALMEIDA SAAVEDRA

IPC分类号： C07C319/14 ,  C07C323/27 ,  C07C319/28 ,  C07C253/30 ,  C07C255/38 ,  C07C253/34 ,  C07C201/12 ,  C07C201/16 ,  C07C205/41 ,  C07C67/40 ,  C07C67/58 ,  C07C69/94 ,  C07C45/45 ,  C07C45/79 ,  C07C49/235 ,  C07C255/35 ,  C07C205/09 ,  C07C255/40 ,  C07C49/255

摘要： The present invention reports the obtaining of carbonyl compounds and derivatives, through syntheses with high yield and purity, providing anti-humoral active principles with selective antiproliferative properties and anti-metastatic activity.
The present invention refers to the development of new polyfunctional push-pull butadienes and their O and C-prenylated, benzoylated and iodide derivatives, with high electronic conjugation in the lateral chain. These compounds exhibit high anti-tumor selectivity, causing cell death by apoptosis, also show anti-metastatic and non-mutagenic properties in the experimental studies performed.

公开(公告)号：US20230099421A1

公开(公告)日：2023-03-30

申请号：US17757653

申请日：2020-12-15

申请人： National University of Singapore

发明人： Rowan Drury Young ,  Dipendu Mandal ,  Richa Gupta ,  Amit Kumar Jaiswal

IPC分类号： C07D213/04 ,  C07D405/10 ,  C07F7/08 ,  C07F7/10 ,  C07F9/54 ,  C07F9/655 ,  C07F9/58 ,  C07C22/08 ,  C07C247/10 ,  C07C331/24 ,  C07C203/04 ,  C07C43/225 ,  C07C69/635 ,  C07C323/09 ,  C07C17/093 ,  C07C201/02 ,  C07C41/16 ,  C07C67/11 ,  C07C319/14 ,  C07B59/00 ,  B01J31/02

摘要： Disclosed herein is a salt of formula I: where R1, X, n, R, R1, Y, m, p, q, Z and o are as defined herein. Also disclosed herein are methods of using said salts in chemical synthesis, such as to prepare compounds isotopically enriched in 18F for use in PET & imaging, as well as methods to make the compounds of formula I.

公开(公告)号：US11427536B2

公开(公告)日：2022-08-30

申请号：US16019914

申请日：2018-06-27

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

发明人： Garret Miyake ,  Bin Liu ,  Chern-Hooi Lim

IPC分类号： C07C319/14 ,  C07D213/70 ,  C07D239/38 ,  C07D285/16 ,  C07D235/28 ,  C07D311/54 ,  C07D215/36 ,  C07D277/74 ,  C07D285/22 ,  B01J19/12

摘要： In one aspect, the invention provides a method of promoting a carbon-sulfur bond forming reaction. In certain embodiments, the reaction comprises cross-coupling of a(n) (hetero)aryl halide with a thiol to form the carbon-sulfur bond, wherein the method is promoted by light irradiation in the absence of a photocatalyst. In other embodiments, the cross-coupling reaction can be promoted through visible light irradiation, including sunlight.

公开(公告)号：US11040965B2

公开(公告)日：2021-06-22

申请号：US16493614

申请日：2018-03-13

申请人： Assembly Biosciences, Inc.

发明人： Leping Li ,  Lee D. Arnold ,  Sreenivasa Reddy Mundla

IPC分类号： C07D417/12 ,  C07C231/10 ,  C07C231/12 ,  C07C315/02 ,  C07C315/04 ,  C07C319/14 ,  C07C319/20

摘要： The present disclosure provides, in part, a process for preparing compounds (I) having allosteric effector properties against Hepatitis B virus Cp.

公开(公告)号：US11021441B2

公开(公告)日：2021-06-01

申请号：US16822189

申请日：2020-03-18

申请人： Wisconsin Alumni Research Foundation

发明人： Shannon S. Stahl ,  James B. Gerken

IPC分类号： C07D285/14 ,  C07D487/04 ,  C07D231/18 ,  C07D209/48 ,  C07C309/42 ,  C07C309/14 ,  C07C323/66 ,  C07C319/14 ,  H01M8/18

摘要： Substituted hydroquinones and quinones and methods of synthesizing such compounds are disclosed herein. The substituted hydroquinones have the formula: while the substituted quinones have the corresponding oxidized structure (1,4-benzoquinones). One, two, three, or all four of R1, R2, R3 and R4 comprise a thioether moiety and a sulfonate moiety, and wherein each R1, R2, R3 and R4 that does not comprise a thioether and a sulfonate moiety sulfonate moiety is independently a hydrogen, an alkyl or an electron withdrawing group. The substituted hydroquinones and quinones are soluble in water, stable in aqueous acid solutions, and have a high reduction potential in the oxidized form. Accordingly, they can be used as redox mediators in emerging technologies, such as in mediated fuel cells or organic-mediator flow batteries.

公开(公告)号：US10975026B2

公开(公告)日：2021-04-13

申请号：US16171476

申请日：2018-10-26

申请人： HOYA LENS THAILAND LTD.

发明人： Yukio Kageyama ,  Masahisa Kousaka ,  Akinori Yamamoto

IPC分类号： C07C319/14 ,  C07C319/20 ,  C07C335/32 ,  G02B1/04 ,  C08G18/24 ,  C08G18/76 ,  C08G18/38

摘要： The method for producing a polythiol compound includes reacting 2-mercaptoethanol having a water content of 3000 ppm or less on a mass basis, with epihalohydrin to obtain a halide represented by the formula (1), wherein X represents a halogen atom; and obtaining at least one polythiol compound selected from the group consisting of a polythiol compound represented by the formula (4), a polythiol compound represented by the formula (5), a polythiol compound represented by the formula (6), and a polythiol compound represented by the formula (7).

公开(公告)号：US10800736B2

公开(公告)日：2020-10-13

申请号：US16605090

申请日：2018-05-09

申请人： Evonik Operations GmbH

发明人： Daniel Fischer ,  Patrik Stenner ,  Sebastian Bernhardt ,  Harald Jakob

IPC分类号： C07C319/20 ,  C07C319/14 ,  C07C319/28 ,  C07C323/58

摘要： A process is used for preparing methionine. Specifically, the process includes the hydrolysis of 5-(2-methylmercaptoethyl)hydantoin (methionine hydantoin) in an alkaline process solution. Further, the by-products that include formate and other anions of organic acids containing 1 to 5 carbon atoms are removed by electrodialysis of the process solution.

公开(公告)号：US10774040B1

公开(公告)日：2020-09-15

申请号：US16396820

申请日：2019-04-29

申请人： Chevron Phillips Chemical Company LP

发明人： Kenneth M. Lassen ,  Michael S. Matson ,  Daniel M. Hasenberg ,  Dave Schwierman

IPC分类号： C07C319/28 ,  C07C319/14 ,  C07C319/06 ,  B01J8/02 ,  C07D277/04 ,  B01D3/02 ,  C07D263/22 ,  C07D263/16 ,  B01D3/00

摘要： Processes for removing carbon disulfide from product streams containing a sulfide compound are performed by contacting the product stream with an alkanolamine and converting the carbon disulfide to a higher boiling point product, thereby reducing or eliminating carbon disulfide from the product stream. Subsequent removal of the higher boiling point product via distillation can lead to a purified sulfide stream with high purity.

公开(公告)号：US20200223794A1

公开(公告)日：2020-07-16

申请号：US16822189

申请日：2020-03-18

申请人： Wisconsin Alumni Research Foundation

发明人： Shannon S. Stahl ,  James B. Gerken

IPC分类号： C07C309/42 ,  C07C323/66 ,  C07C319/14 ,  C07D285/14 ,  C07D209/48 ,  C07D231/18 ,  C07D487/04 ,  H01M8/18

摘要： Substituted hydroquinones and quinones and methods of synthesizing such compounds are disclosed herein. The substituted hydroquinones have the formula: while the substituted quinones have the corresponding oxidized structure (1,4-benzoquinones). One, two, three, or all four of R1, R2, R3 and R4 comprise a thioether moiety and a sulfonate moiety, and wherein each R1, R2, R3 and R4 that does not comprise a thioether and a sulfonate moiety sulfonate moiety is independently a hydrogen, an alkyl or an electron withdrawing group.The substituted hydroquinones and quinones are soluble in water, stable in aqueous acid solutions, and have a high reduction potential in the oxidized form. Accordingly, they can be used as redox mediators in emerging technologies, such as in mediated fuel cells or organic-mediator flow batteries.