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    Photolabile protective groups for improved processes to prepare oligonucleotide arrays
    2.
    发明授权
    Photolabile protective groups for improved processes to prepare oligonucleotide arrays 有权
    用于制备寡核苷酸阵列的改进方法的光不稳定保护基

    公开(公告)号：US08445734B2

    公开(公告)日：2013-05-21

    申请号：US12792122

    申请日：2010-06-02

    Applicant: Sigrid Buehler ,  Markus Ott ,  Wolfgang Pfleiderer

    Inventor： Sigrid Buehler ,  Markus Ott ,  Wolfgang Pfleiderer

    IPC: C07C205/19 ,  C07H21/02 ,  C07H21/04

    CPC classification number: C07H13/12 ,  C07H19/06 ,  C07H19/16 ,  C07H21/00 ,  Y02P20/55

    Abstract: The present invention discloses novel and improved nucleosidic and nucleotidic compounds that are useful in the light-directed synthesis of oligonucleotides, as well as, methods and reagents for their preparation. These compounds are characterized by novel photolabile protective groups that are attached to either the 5′- or the 3′-hydroxyl group of a nucleoside moiety. The photolabile protective group is comprised of a 2-(2-nitrophenyl)-ethyoxycarbonyl skeleton with at least one substituent on the aromatic ring that is either an aryl, an aroyl, a heteroaryl or an alkoxycarbonyl group. The present invention includes the use of the aforementioned compounds in light-directed oligonucleotide synthesis, the respective assembly of nucleic acid microarrays and their application.

    Abstract translation: 本发明公开了可用于寡核苷酸的光定向合成的新型和改进的核苷和核苷酸化合物，以及其制备方法和试剂。 这些化合物的特征在于与核苷部分的5'-或3'-羟基连接的新的光不稳定保护基。 光不稳定保护基由在芳环上具有芳基，芳酰基，杂芳基或烷氧基羰基的至少一个取代基的2-（2-硝基苯基） - 乙氧基羰基骨架组成。 本发明包括上述化合物在光导寡核苷酸合成中的用途，核酸微阵列的各自组装及其应用。

    Process for the preparation of o-nitrophenetole
    8.
    发明授权
    Process for the preparation of o-nitrophenetole 失效
    制备邻硝基苯甲醚的方法

    公开(公告)号：US4954657A

    公开(公告)日：1990-09-04

    申请号：US267170

    申请日：1988-11-04

    Applicant: Hartmut Heise ,  Manfred Hintzmann

    Inventor： Hartmut Heise ,  Manfred Hintzmann

    IPC: C07B61/00 ,  B01J31/02 ,  C07C67/00 ,  C07C201/00 ,  C07C205/19 ,  C07C205/37

    CPC classification number: C07C201/12

    Abstract: A process for the preparation of o-nitrophenetole by allowing about 1.05 to about 1.4 mole of ethanol to act on 1 mole of o-nitrochlorobenzene in the presence of a phase-transfer catalyst in approximately 40 to approximately 70 percent by weight alkali metal hydroxide solution at temperatures from about 50.degree. to about 80.degree. C. in such a way that the ethanol concentration in the reaction mixture does not exceed 1.5 percent by weight throughout the course of the reaction.

    Abstract translation: 在约40至约70重量％的碱金属氢氧化物溶液中，在相转移催化剂存在下，通过使约1.05至约1.4摩尔的乙醇作用于1摩尔邻硝基氯苯上，制备邻硝基苯甲醚的方法 在约50℃至约80℃的温度下，使反应混合物中的乙醇浓度在整个反应过程中不超过1.5重量％。

    Process for the preparation of nitrophenylalkanols
    9.
    发明授权
    Process for the preparation of nitrophenylalkanols 失效
    硝基苯基链烷醇的制备方法

    公开(公告)号：US4497966A

    公开(公告)日：1985-02-05

    申请号：US529910

    申请日：1983-09-07

    Applicant: Robert van Helden ,  Petrus A. Kramer

    Inventor： Robert van Helden ,  Petrus A. Kramer

    IPC: C07C205/19 ,  C07C79/24

    CPC classification number: C07C201/12

    Abstract: Nitrophenylalkanols are prepared by hydroxyalkylation of nitrotoluene(s) by the reaction with an aldehyde in the presence of a solid catalyst prepared by depositing an alkali metal compound on an alumina support.

    Abstract translation: 在通过在氧化铝载体上沉积碱金属化合物制备的固体催化剂存在下，通过与醛的反应，硝基甲苯的羟基烷基化制备硝基苯基链烷醇。

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