Invention Grant
US5439943A Non-steroid and non-prostanoid inhibitors of steroid and prostaglandin
transforming enzymes
失效
类固醇和前列腺素转化酶的非类固醇和非前列腺素类抑制剂
- Patent Title: Non-steroid and non-prostanoid inhibitors of steroid and prostaglandin transforming enzymes
- Patent Title (中): 类固醇和前列腺素转化酶的非类固醇和非前列腺素类抑制剂
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Application No.: US336833Application Date: 1994-11-09
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Publication No.: US5439943APublication Date: 1995-08-08
- Inventor: Trevor M. Penning , Joseph W. Ricigliano
- Applicant: Trevor M. Penning , Joseph W. Ricigliano
- Applicant Address: PA Philadelphia
- Assignee: Trustees of the University of Pennsylvania
- Current Assignee: Trustees of the University of Pennsylvania
- Current Assignee Address: PA Philadelphia
- Main IPC: C07C205/19
- IPC: C07C205/19 ; C07C205/45 ; C07C229/58 ; C12N9/04 ; C12N9/99 ; C12P7/26 ; A01N35/00 ; A61K31/11
Abstract:
Compounds such as 1-(4'-nitrophenyl)-2-propen-1-ol are disclosed which are non-steroidal mechanism-based inactivators of rat liver 3.alpha.-hydroxysteroid dehydrogenase. The corresponding ketones are time dependent inactivators of cyclooxygenase (PGH.sub.2 -synthase).
Public/Granted literature
- US4915828A Aquarium filter Public/Granted day:1990-04-10
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