公开(公告)号：US20180163158A1

公开(公告)日：2018-06-14

申请号：US15578629

申请日：2016-06-03

Applicant: P2 SCIENCE, INC.

Inventor： Patrick FOLEY ,  Yonghua YANG

IPC: C11B9/00 ,  C07C29/143 ,  C07C45/72 ,  C07C45/69 ,  C07C49/543 ,  C07C33/14 ,  C07C43/162 ,  A23L27/20

CPC classification number: C11B9/0034 ,  A23L27/203 ,  A23V2002/00 ,  A61K8/34 ,  A61Q13/00 ,  C07C29/143 ,  C07C33/14 ,  C07C43/162 ,  C07C45/69 ,  C07C45/72 ,  C07C49/543 ,  C07C69/007 ,  C07C69/24 ,  C07C2601/16

Abstract: The present application relates to the preparation of cyclohexyl-alkyl carbinols, including 1-(cyclohex-3-en-1-yl)-2-methylpropan-1-ol, which possesses a minty aroma that can be described as fresh, invigorating, and menthol-like, and also possesses cooling properties. The use of cyclohexyl-alkyl carbinols as readily accessible and cost effective fragrance, flavor, and cooling ingredients, and potential applications thereof is also described.

公开(公告)号：US20180148403A1

公开(公告)日：2018-05-31

申请号：US15884742

申请日：2018-01-31

Applicant: ZOGENIX INTERNATIONAL LIMITED

Inventor： Derek J. LONDESBROUGH ,  Marc W. ANDERSEN

IPC: C07C209/28 ,  C07C211/29 ,  C07C209/84 ,  C07C51/43 ,  C07C51/08 ,  C07C45/80 ,  C07C45/72

CPC classification number: C07C209/28 ,  C07B2200/13 ,  C07C45/72 ,  C07C45/80 ,  C07C51/08 ,  C07C51/43 ,  C07C209/84 ,  C07C211/29 ,  C07C57/58 ,  C07C49/233

Abstract: Methods of preparing a fenfluramine active pharmaceutical ingredient are provided. Aspects of the method include (a) hydrolyzing a 2-(3-(trifluoromethyl)phenyl)acetonitrile composition to produce a 2-(3-(trifluoromethyl)phenyl)acetic acid composition; (b) reacting the 2-(3-(trifluoromethyl)phenyl)acetic acid composition with acetic anhydride and a catalyst to produce a 1-(3-(trifluoromethyl)phenyl)propan-2-one composition; and (c) reductively aminating the 1-(3-(trifluoromethyl)phenyl)propan-2-one composition with ethylamine using a borohydride reducing agent to produce a fenfluramine composition. Also provided are compositions and pharmaceutical ingredients prepared according to the subject methods including a pharmaceutically acceptable salt of fenfluramine and having less than 0.2% by weight in total of trifluoromethyl regioisomers.

公开(公告)号：US20180141882A1

公开(公告)日：2018-05-24

申请号：US15316296

申请日：2015-06-08

Applicant: IGM RESINS ITALIA S.R.L.

Inventor： Gabriele NORCINI ,  Angelo CASIRAGHI ,  Enzo MENEGUZZO ,  Giovanni FLORIDI ,  Giuseppe LI BASSI

IPC: C07C13/465 ,  C07C17/14 ,  C07C22/04 ,  C07C45/42 ,  C07C45/46 ,  C07C45/63 ,  C07C45/64 ,  C07C45/65 ,  C07C45/72 ,  C07C45/81 ,  C07C49/788 ,  C07C49/792 ,  C07C49/794 ,  C07C49/82

CPC classification number: C07C13/465 ,  C07C17/14 ,  C07C22/04 ,  C07C45/42 ,  C07C45/46 ,  C07C45/63 ,  C07C45/64 ,  C07C45/65 ,  C07C45/72 ,  C07C45/81 ,  C07C49/788 ,  C07C49/792 ,  C07C49/794 ,  C07C49/82 ,  C07C2523/04 ,  C07C49/76 ,  C07C49/80

Abstract: The present invention refers to a process for producing 5-[4-(2-hydroxy-2-methyl)-1-oxo-prop-1-yl]-3-[4-(2-hydroxy-2-methyl)-1-oxo-prop-1-yl-phenyl]-2,3-dihydro-1,1,3-trimethyl-1H-indene (dimer isomer 5) that comprises the synthesis from cumene and dimerization of 2-methyl-1-(4-(prop-1-en-2-yl)phenyl)propan-1-one in the presence of acid catalysts.

公开(公告)号：US09878305B2

公开(公告)日：2018-01-30

申请号：US15182248

申请日：2016-06-14

Applicant: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

Inventor： Mohammad M. Hossain ,  Afees A. Ayandiran ,  Shaikh A. Razzak ,  Housam Binous

IPC: B01J21/04 ,  B01J23/22 ,  B01J23/02 ,  B01J35/00 ,  B01J35/02 ,  B01J35/10 ,  B01J37/04 ,  B01J37/18 ,  B01J37/14 ,  C07C5/48

CPC classification number: B01J23/22 ,  B01J35/002 ,  B01J35/0026 ,  B01J35/023 ,  B01J35/026 ,  B01J35/1009 ,  B01J35/1014 ,  B01J37/0203 ,  B01J37/08 ,  B01J37/18 ,  B01J2523/00 ,  C07C5/48 ,  C07C45/66 ,  C07C45/72 ,  C07C67/31 ,  C07C2521/04 ,  C07C2523/02 ,  C07C2523/22 ,  B01J2523/23 ,  B01J2523/31 ,  B01J2523/55 ,  C07C11/06

Abstract: Fluidizable catalysts for the gas phase oxygen-free oxidative dehydrogenation of alkanes, such as propane, to corresponding olefins, such as propylene. The catalysts comprise 5-20% by weight per total catalyst weight of one or more vanadium oxides (VOx), such as V2O5. The dehydrogenation catalysts are disposed on an alumina support that is modified with calcium oxide to influence characteristics of lattice oxygen at the catalyst surface. Various methods of preparing and characterizing the catalyst as well as methods for the gas phase oxygen free oxidative dehydrogenation of alkanes, such as propane, to corresponding olefins, such as propylene, with improved alkane conversion and olefin product selectivity are also disclosed.

公开(公告)号：US20170327449A1

公开(公告)日：2017-11-16

申请号：US15536612

申请日：2015-12-16

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE MONTPELLIER

Inventor： Claude GRISON ,  Vincent ESCANDE ,  Andrii STANOVYCH

IPC: C07C45/75 ,  C07C45/72

CPC classification number: C07C45/75 ,  C07C45/72 ,  C07C49/12 ,  C07C49/213 ,  C07C2601/10 ,  C07C49/597 ,  C07C49/203

Abstract: Disclosed is a process for preparing a product of formula I: wherein the reaction is catalyzed both by thiamine or a thiamine salt and by ascorbic acid in a form which is free or salified or an organic acid salt of an alkaline metal, preferably sodium acetate, potassium tartrate, sodium succinate, or a reductone, preferably 2-hydroxypropanedial or 2,3-dihydroxycyclopent-2-ene-1-one in an organic solvent.

公开(公告)号：US09604891B2

公开(公告)日：2017-03-28

申请号：US14660401

申请日：2015-03-17

Applicant: Central Glass Company, Limited

Inventor： Hitoshi Oomuro ,  Ryo Nadano ,  Masafumi Hirotsu

IPC: C07C29/141 ,  C07C45/72 ,  C07C67/08 ,  C08F220/22 ,  C08F220/28 ,  C08L33/14 ,  G03F7/00

CPC classification number: C07C29/141 ,  C07C45/72 ,  C07C67/08 ,  C08F220/22 ,  C08F220/28 ,  C08L33/14 ,  G03F7/00 ,  G03F7/0046 ,  G03F7/0397 ,  C07C47/195 ,  C07C31/42 ,  C07C69/653 ,  C08F2220/185 ,  C08F2220/282 ,  C08F2220/1883 ,  C08K5/42

Abstract: As shown by the following reaction formula, disclosed is a fluorine-containing hydroxyaldehyde production method, including the step of obtaining a fluorine-containing hydroxyaldehyde represented by the general formula (1) by reacting a fluorine-containing ketone represented by the general formula (4) and an aldehyde represented by the general formula (5) in the presence of an organic base selected from a heterocyclic compound which contains a nitrogen atom in its ring or a tertiary amine. By this production method, it is possible to obtain the fluorine-containing hydroxyaldehyde in a high yield. Furthermore, it is possible to easily obtain in high yields a fluorine-containing propanediol, which is a derivative of this fluorine-containing hydroxyaldehyde, and a fluorine-containing alcohol monomer by using the same.

公开(公告)号：US20160115143A1

公开(公告)日：2016-04-28

申请号：US14895851

申请日：2014-06-03

Applicant: BP CORPORATION NORTH AMERICA INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Eric SACIA ,  Anbarasan PAZHAMALAI ,  Balakrishnan MADHESAN ,  Sanil SREEKUMAR ,  F. Dean TOSTE ,  Amit A. GOKHALE ,  Martin E. CARRERA ,  Alexis T. BELL ,  Gorkem GUNBAS

IPC: C07D307/46 ,  C10L1/08 ,  C07C1/207 ,  C10L1/06 ,  C07C45/72 ,  C07C45/68

CPC classification number: C07D307/46 ,  C07C1/2076 ,  C07C1/22 ,  C07C29/175 ,  C07C45/66 ,  C07C45/68 ,  C07C45/71 ,  C07C45/72 ,  C07C45/74 ,  C07C2523/42 ,  C07C2523/44 ,  C07C2523/46 ,  C07C2601/08 ,  C07C2601/10 ,  C10G3/50 ,  C10L1/06 ,  C10L1/08 ,  C10L1/1608 ,  C10L1/182 ,  C10L2200/0423 ,  C10L2200/0446 ,  C10L2270/023 ,  C10L2270/026 ,  C10M127/02 ,  C10M129/06 ,  C10M2203/022 ,  C10M2203/04 ,  C10M2207/021 ,  C10N2270/00 ,  Y02P30/20 ,  C07C49/203 ,  C07C35/06 ,  C07C13/10 ,  C07C49/17 ,  C07C47/19 ,  C07C49/597

Abstract: The present disclosure generally relates to the production of fuels, gasoline additives, and/or lubricants, and precursors thereof. The compounds used to produce the fuels, gasoline additives, and/or lubricants, and precursors thereof may be derived from biomass. The fuels, gasoline additives, and/or lubricants, and precursors thereof may be produced by a combination of intermolecular and/or intramolecular aldol condensation reactions, Guerbet reactions, hydrogenation reactions, and/or oligomerization reactions.

Abstract translation: 本公开一般涉及燃料，汽油添加剂和/或润滑剂及其前体的生产。 用于生产燃料，汽油添加剂和/或润滑剂及其前体的化合物可以衍生自生物质。 燃料，汽油添加剂和/或润滑剂及其前体可以通过分子间和/或分子内醛醇缩合反应，Guerbet反应，氢化反应和/或低聚反应的组合产生。

公开(公告)号：US20150376511A1

公开(公告)日：2015-12-31

申请号：US14744945

申请日：2015-06-19

Applicant: PHILLIPS 66 COMPANY

Inventor： Edgar LOTERO ,  Sourabh S. PANSARE ,  Kristi A. Fjare

IPC: C10G3/00 ,  C07C45/72 ,  C07D307/12 ,  C07C45/45 ,  C10L1/04 ,  C07C29/09

CPC classification number: C10G3/50 ,  C07C1/22 ,  C07C29/09 ,  C07C29/103 ,  C07C45/45 ,  C07C45/72 ,  C07C45/74 ,  C07D307/12 ,  C10G3/42 ,  C10G3/44 ,  C10G29/22 ,  C10G2300/1014 ,  C10G2400/08 ,  C10L1/04 ,  C10L2200/0469 ,  C10L2270/04 ,  Y02P30/20 ,  C07C31/20 ,  C07C49/203 ,  C07C9/14

Abstract: The present invention is related to the production of jet fuel-range hydrocarbons from cellulose/hemicellulose derived alcohols, such as pentanediol and/or hydroxymethyl-tetrahydrofuran which is also known as tetrahydrofurfuryl alcohol. The alcohols are spliced or dimerized through Guerbet chemistry where longer chain organic molecules are formed using an alcohol condensation catalyst. The organic molecules are hydrotreated to remove oxygen to yield jet fuel-range hydrocarbons.

Abstract translation: 本发明涉及由纤维素/半纤维素衍生的醇如戊二醇和/或也称为四氢糠醇的羟甲基四氢呋喃生产喷气燃料型烃。 醇通过Guerbet化学结合或二聚化，其中使用醇缩合催化剂形成更长链的有机分子。 将有机分子加氢处理以除去氧气以产生喷射燃料范围的烃。

公开(公告)号：US08609572B2

公开(公告)日：2013-12-17

申请号：US11794772

申请日：2006-01-04

Applicant: Martyn J. Earl ,  Kenneth R. Seddon ,  Stewart Forsyth ,  Ute Frohlich ,  Nimal Gunaratne ,  Suhas Katdare

Inventor： Martyn J. Earl ,  Kenneth R. Seddon ,  Stewart Forsyth ,  Ute Frohlich ,  Nimal Gunaratne ,  Suhas Katdare

IPC: B01J31/00

CPC classification number: C07C217/08 ,  B01J31/0201 ,  B01J31/0204 ,  B01J31/0225 ,  B01J31/0234 ,  B01J31/0237 ,  B01J31/0277 ,  B01J31/0278 ,  B01J31/0282 ,  B01J31/0284 ,  B01J31/0287 ,  B01J31/0288 ,  B01J31/0289 ,  B01J31/0291 ,  B01J31/2208 ,  B01J2231/341 ,  B01J2231/342 ,  B01J2231/346 ,  B01J2231/348 ,  B01J2231/349 ,  B01J2231/4261 ,  B01J2231/645 ,  B01J2231/72 ,  B01J2531/824 ,  B01J2531/90 ,  C07B61/00 ,  C07C45/512 ,  C07C45/62 ,  C07C45/66 ,  C07C45/67 ,  C07C45/72 ,  C07C45/73 ,  C07C45/74 ,  C07C211/63 ,  C07D213/73 ,  C07D233/54 ,  C07D303/32 ,  Y02P20/542 ,  C07C47/228 ,  C07C49/603 ,  C07C49/647 ,  C07C49/637 ,  C07C49/203 ,  C07C49/597 ,  C07C49/497 ,  C07C49/707 ,  C07C49/17 ,  C07C49/403

Abstract: Use of ionic liquids as solvents in base-catalysed chemical reactions wherein the ionic liquid is composed of at least one species of cation and at least one species of anion, characterized in that a cation of the ionic liquid comprises a positively charge moiety and a basic moiety, and further wherein such ionic liquids may be used as promoters or catalysts for the chemical reactions.

Abstract translation: 在碱催化的化学反应中使用离子液体作为溶剂，其中离子液体由至少一种阳离子和至少一种阴离子组成，其特征在于离子液体的阳离子包含正电荷部分和碱性 部分，其中这种离子液体可以用作化学反应的促进剂或催化剂。

公开(公告)号：US20130079396A1

公开(公告)日：2013-03-28

申请号：US13623161

申请日：2012-09-20

Applicant: Council of Scientific and Industrial Research

Inventor： Arvind Singh Negi ,  Ayyampudur Palanisamy Prakasham ,  Ajit Kumar Saxena ,  Suaib Luqman ,  Debabrata Chanda ,  Tandeep Kaur ,  Atul Gupta

IPC: C07C49/755 ,  C07C201/12 ,  C07C45/72 ,  C07D317/54 ,  C07C205/45

CPC classification number: C07C49/755 ,  C07C45/72 ,  C07C45/74 ,  C07C201/12 ,  C07C205/45 ,  C07C2102/08 ,  C07C2602/08 ,  C07D317/54

Abstract: The present invention relates to benzylidene indanones of general formula 1. The compounds exhibited tubulin polymerisation inhibition. A series of compounds 2-benzylidene 3-(3,4,5-trimethoxyphenyl) indanones having general formulae 1 were synthesized from gallic acid through a chemical process. 2-(3,4-Methylenedioxybenzylidine), 3-(3,4,5-trimethoxyphenyl), 4,5,6-trimethoxyindanone (8), a representative compound of this series possessing the molecular formulae C29H28O9, was synthesized from gallic acid and exhibits potent anticancer activity. Compound 8 was evaluated for acute oral activity in Swiss albino mice and found to be safe up to 300 mg/kg body weight. The anticancer activity of the compounds has been determined, in order to obtain new potent and cost effective molecules using an in vitro cytotoxicity assay.

Abstract translation: 本发明涉及通式1的亚苄基茚满酮。该化合物表现出微管蛋白聚合抑制作用。 通过化学方法由没食子酸合成一系列化合物，具有通式1的2-亚苄基3-（3,4,5-三甲氧基苯基）茚满酮。 2-（3,4-亚甲基二氧基亚苄基），3-（3,4,5-三甲氧基苯基），4,5,6-三甲氧基茚满酮（8），具有分子式C29H28O9的该系列的代表性化合物，由没食子酸 并具有很强的抗癌活性。 评估化合物8在瑞士白化病小鼠中的急性口服活性，发现其安全性高达300mg / kg体重。 已经确定了化合物的抗癌活性，以便使用体外细胞毒性测定来获得新的有效和成本有效的分子。