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    Alpha- and chi-diketone reactants for charge transfer reactions in mass spectrometers
    1.
    发明授权
    Alpha- and chi-diketone reactants for charge transfer reactions in mass spectrometers 有权
    用于质谱仪中电荷转移反应的α-和二 - 二酮反应物

    公开(公告)号：US09557297B2

    公开(公告)日：2017-01-31

    申请号：US13667018

    申请日：2012-11-02

    申请人： Bruker Daltonik GmbH

    发明人： Ralf Hartmer

    IPC分类号： G01N24/00 ,  G01N27/62 ,  H01J49/00 ,  C07C49/12 ,  C07C49/203 ,  C07C49/403 ,  C07C49/437

    CPC分类号： G01N27/62 ,  C07C49/12 ,  C07C49/203 ,  C07C49/403 ,  C07C49/437 ,  C07C2601/14 ,  C07C2602/42 ,  H01J49/0072 ,  Y10T436/24

    摘要： The invention relates to the use of substances for the production of anions suitable for charge transfer reactions in mass spectrometers, particularly for the fragmentation of multiply positively charged biopolymer ions by electron transfer or for charge reduction by proton transfer. Diketones, particularly α-diketones, are proposed as a newly found class of substances which can be used both for the production of radical anions for electron transfer dissociations (ETD) with a high yield of fragment ions and also for the production of non-radical anions for the charge reduction of multiply charged analyte ions by proton transfer reactions (PTR). These substances have favorable properties in terms of their handling and the associated analytical methods: they are largely nontoxic, cover a favorable range of molecular masses, and their volatility means that they can be stored in unheated containers outside of the vacuum system, which facilitates the refilling of the containers.

    摘要翻译： 本发明涉及用于生产适用于质谱仪中的电荷转移反应的阴离子的物质的用途，特别是通过电子转移或通过质子转移进行电荷还原的多重带正电荷的生物聚合物离子的断裂。 Diketones，特别是α-二酮被提出作为新发现的一类物质，可以用于生产具有高产率碎片离子的电子转移离解（ETD）的自由基阴离子，并且用于生成非自由基 通过质子转移反应（PTR）对多重电荷的分析物离子进行电荷还原的阴离子。 这些物质在其处理和相关分析方法方面具有良好的性质：它们在很大程度上是无毒的，涵盖了有利的分子量范围，并且它们的挥发性意味着它们可以储存在真空系统外的未加热的容器中，这便于 重新填充容器。

    MAGNETIC RESONANCE IMAGING AND/OR SPECTROSCOPY CONTRAST AGENTS AND METHODS OF USE THEREOF
    2.
    发明申请
    MAGNETIC RESONANCE IMAGING AND/OR SPECTROSCOPY CONTRAST AGENTS AND METHODS OF USE THEREOF 审中-公开
    磁共振成像和/或光谱对比剂及其使用方法

    公开(公告)号：US20150258220A1

    公开(公告)日：2015-09-17

    申请号：US14620847

    申请日：2015-02-12

    申请人： Duke University

    发明人： Warren S. Warren

    IPC分类号： A61K49/08 ,  A61K49/18 ,  C07C49/12

    CPC分类号： A61K49/08 ,  A61K49/18 ,  A61K49/1812 ,  C07C49/12 ,  G01R33/282 ,  G01R33/5601 ,  G01R33/5605

    摘要： The presently disclosed subject matter demonstrates that a spin state which has zero magnetic resonance signal, but an extremely long lifetime, can be used to store magnetization, which can then be recovered into an observable transition. Coupled with hyperpolarization techniques, this permits the preparation of a wide range of contrast agent molecules for use in magnetic resonance imaging (MRI) techniques that have long effective relaxation time.

    摘要翻译： 目前公开的主题表明，具有零磁共振信号但具有极长寿命的自旋状态可以用于存储磁化，然后可以将其恢复到可观察的转变中。 结合超极化技术，这允许制备用于具有长效有效弛豫时间的磁共振成像（MRI）技术的大范围造影剂分子。

    REACTANTS FOR CHARGE TRANSFER REACTIONS IN MASS SPECTROMETERS
    4.
    发明申请
    REACTANTS FOR CHARGE TRANSFER REACTIONS IN MASS SPECTROMETERS 有权
    大量光谱仪中电荷转移反应的反应物

    公开(公告)号：US20130115711A1

    公开(公告)日：2013-05-09

    申请号：US13667018

    申请日：2012-11-02

    申请人： Bruker Daltonik GmbH

    发明人： Ralf Hartmer

    IPC分类号： G01N27/62

    CPC分类号： G01N27/62 ,  C07C49/12 ,  C07C49/203 ,  C07C49/403 ,  C07C49/437 ,  C07C2601/14 ,  C07C2602/42 ,  H01J49/0072 ,  Y10T436/24

    摘要： The invention relates to the use of substances for the production of anions suitable for charge transfer reactions in mass spectrometers, particularly for the fragmentation of multiply positively charged biopolymer ions by electron transfer or for charge reduction by proton transfer. Diketones, particularly α-diketones, are proposed as a newly found class of substances which can be used both for the production of radical anions for electron transfer dissociations (ETD) with a high yield of fragment ions and also for the production of non-radical anions for the charge reduction of multiply charged analyte ions by proton transfer reactions (PTR). These substances have favorable properties in terms of their handling and the associated analytical methods: they are largely nontoxic, cover a favorable range of molecular masses, and their volatility means that they can be stored in unheated containers outside of the vacuum system, which facilitates the refilling of the containers.

    摘要翻译： 本发明涉及用于生产适用于质谱仪中的电荷转移反应的阴离子的物质的用途，特别是通过电子转移或通过质子转移进行电荷还原的多重带正电荷的生物聚合物离子的断裂。 提出了二酮，特别是α-二酮作为新发现的一类物质，它们可用于生产具有高产率碎片离子的电子转移离解（ETD）的自由基阴离子，也用于生成非自由基 通过质子转移反应（PTR）对多重电荷的分析物离子进行电荷还原的阴离子。 这些物质在其处理和相关分析方法方面具有良好的性质：它们在很大程度上是无毒的，涵盖了有利的分子量范围，并且它们的挥发性意味着它们可以储存在真空系统外的未加热的容器中，这便于 重新填充容器。

    Method of enhancing fragrance by adding optically active muscone composition
    7.
    发明授权
    Method of enhancing fragrance by adding optically active muscone composition 有权
    通过添加光学活性肌肉酮组合物来增强香味的方法

    公开(公告)号：US08093203B2

    公开(公告)日：2012-01-10

    申请号：US11719109

    申请日：2004-11-12

    申请人： Kenichi Yamamoto ,  Misao Yagi ,  Hiroyuki Matsuda ,  Kenji Maruyama

    发明人： Kenichi Yamamoto ,  Misao Yagi ,  Hiroyuki Matsuda ,  Kenji Maruyama

    IPC分类号： A61Q13/00 ,  A61K31/12 ,  A61K47/00 ,  A61K8/02

    CPC分类号： C11B9/0038 ,  C07C45/62 ,  C07C45/66 ,  C07C45/676 ,  C07C49/385 ,  C07C49/587 ,  C07C49/12

    摘要： The object of the invention relates to a development of a new musk-feeling fragrance material which is a highly scenting musk-feeling fragrance, and is to provide a fragrance composition which, when added to fragrances or cosmetics, can improve the fixative property and express a high performance and excellent musky aromatic quality.A fragrance composition is prepared using, as the active ingredient, a mixture of (R)-form of optically active muscone with (S)-form of optically active muscone with the mixing ratio thereof within the range of from 90:10 to 95:5 (weight ratio) in terms of weight ratio, or a mixture of (R)-form of optically active muscone with (S)-form of optically active muscone with the mixing ratio thereof within the range of from 75:25 to 80:20 (weight ratio) in terms of weight ratio.

    摘要翻译： 本发明的目的是开发一种高度香味的麝香感香料的新的麝香感香料，并且提供一种香料组合物，当添加到香料或化妆品中时，可以提高固色性能和表达 高性能和优良的麝香芳香品质。 作为活性成分，使用光学活性肌肉酮的（R）型与光学活性肌肉的（S）型混合，其混合比例为90:10〜95:9的范围制备香料组合物。 5（重量比）或光学活性肌肉的（R）形式与（S）型光学活性肌肉酮的混合物的混合比在75:25至80:1的范围内， 20（重量比）的重量比。

    Processes for preparing beta-diketone compound, metal complex thereof and metallic compound
    8.
    发明申请
    Processes for preparing beta-diketone compound, metal complex thereof and metallic compound 失效
    制备β-二酮化合物，其金属络合物和金属化合物的方法

    公开(公告)号：US20070098897A1

    公开(公告)日：2007-05-03

    申请号：US10559809

    申请日：2004-05-20

    申请人： Makoto Saito ,  Takashi Ueda ,  Takashi Tani ,  Keiichi Nakumura

    发明人： Makoto Saito ,  Takashi Ueda ,  Takashi Tani ,  Keiichi Nakumura

    IPC分类号： C23C16/00 ,  B05D3/02 ,  C07F7/28 ,  C07C45/45

    CPC分类号： C07C49/92 ,  C07C45/455 ,  C07C45/77 ,  C07C45/80 ,  C07C49/12

    摘要： Disclosed is a process for preparing a β-diketone compound such as 2,6-dimethyl-3,5-heptanedione, which comprises reacting an ester compound such as an alkyl isobutyrate with a ketone compound such as 3-methylbutanone in the presence of an alkali metal alkoxide as a catalyst. The process comprises a step 1 in which an ester compound CR1R2R3COOQ is reacted with a ketone compound CR4R5R6COCH2R7 using an alkali metal alkoxide catalyst to give a β-diketone compound CR1R2R3COCHR4R5R6. (In the formulae, R7 is hydrogen or an alkyl group of 1 to 4 carbon atoms while others are each independently hydrogen or an alkyl group of 1 to 3 carbon atoms, and at least one of R1 to R6 is hydrogen.)

    摘要翻译： 公开了一种制备2,6-二甲基-3,5-庚二酮的β-二酮化合物的方法，该方法包括使异氰酸烷基酯等酯化合物与3-甲基丁酮等酮化合物在 碱金属醇盐作为催化剂。 该方法包括步骤1，其中酯化合物CR 1 R 2 SO 3 COOQ与酮化合物CR 4 使用碱金属醇盐催化剂，得到β5，R 6，R 5，R 7，R 7， 二酮化合物CR 1 R 2 R 2 SO 3 R 4 R 5 R 5 SUP> 6 。 （式中，R 7为氢或1〜4个碳原子的烷基，其余各自独立地为氢或1〜3个碳原子的烷基，R 1〜 SUP> 1至R 6是氢。）

    Method for producing dicarbonyl compounds
    10.
    发明授权
    Method for producing dicarbonyl compounds 失效
    二羰基化合物的制备方法

    公开(公告)号：US06689918B2

    公开(公告)日：2004-02-10

    申请号：US10275982

    申请日：2002-11-19

    申请人： Uta Glufke ,  Paul Hanselmann

    发明人： Uta Glufke ,  Paul Hanselmann

    IPC分类号： C07C4540

    CPC分类号： C07C45/65 ,  C07C45/40 ,  C07C45/75 ,  C07C49/12 ,  C07C49/203

    摘要： A method for producing &agr;-dicarbonyl compounds of formula (I): wherein R1 and R2, independently of each other, mean C1-6-alkyl. In the method, an &agr;,&bgr;-unsaturated ketone of formula (II): wherein R1 and R2 have the meaning above and R3 and R4, independently of each other, mean hydrogen, C1-6-alkyl or di-C1-6-alkylamino, is reacted with ozone in the absence of a catalyst and the resultant ozonide is treated reductively.

    摘要翻译： 制备式（I）的α-二羰基化合物的方法：其中R 1和R 2彼此独立地是C 1-6 - 烷基。 在该方法中，式（II）的α，β-不饱和酮：其中R 1和R 2具有上述含义，R 3和R 4彼此独立地表示氢， C 1-6 - 烷基或二-C 1-6 - 烷基氨基与臭氧在不存在催化剂的情况下反应，并且所得臭氧化物被还原处理。