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    BASE GENERATOR, BASE-REACTIVE COMPOSITION CONTAINING SAID BASE GENERATOR, AND BASE GENERATION METHOD
    6.
    发明申请
    BASE GENERATOR, BASE-REACTIVE COMPOSITION CONTAINING SAID BASE GENERATOR, AND BASE GENERATION METHOD 审中-公开
    基站发生器，含有基站发生器的基板反应组合物和基站生成方法

    公开(公告)号：US20160122292A1

    公开(公告)日：2016-05-05

    申请号：US14901525

    申请日：2014-06-25

    Applicant: WAKO PURE CHEMICAL INDUSTRIES, LTD. ,  TOKYO UNIVERSITY OF SCIENCE FOUNDATION

    Inventor： Nobuhiko SAKAI ,  Kosuke YANABA ,  Koji ARIMITSU

    IPC: C07C279/26 ,  G03F7/004 ,  C07C65/28 ,  C07D209/48 ,  C07C59/84 ,  C07D311/86

    CPC classification number: C07C279/26 ,  B01J19/123 ,  B01J19/127 ,  B01J19/128 ,  C07C59/84 ,  C07C65/28 ,  C07C2601/14 ,  C07C2603/24 ,  C07D209/48 ,  C07D311/86 ,  G03F7/0045

    Abstract: It is a subject of the present invention to provide a base generator which has high solubility to general-purpose organic solvents, can dissolve directly into a base-reactive compound, such as an epoxy-based compound, further is provided with both performance of high heat resistance and low nucleophilicity, and generates a strong base, a base-reactive composition comprising the base generator and a base-reactive compound, as well as a method for generating a base, etc.The present invention relates to a compound represented by the general formula (A), a base generator comprising the compound, a base-reactive composition which comprises the base generator and a base-reactive compound, as well as a method for generating a base, etc. (wherein R1 to R5 each independently represent a hydrogen atom; an alkyl group; an aryl group which may have a substituent; or an arylalkyl group which may have a substituent, R6 represents a hydrogen atom; an alkyl group which may have a substituent; an alkenyl group; an alkynyl group; an aryl group which may have a substituent; or an arylalkyl group which may have a substituent, R7 represents a hydrogen atom; an alkyl group which may have an amino group; an aryl group which may have a substituent; or an arylalkyl group which may have a substituent, and Z− represents an anion derived from a carboxylic acid having a specific structure.)

    Abstract translation: 本发明的主题是提供一种对通用有机溶剂具有高溶解度的碱发生剂，可以直接溶解在诸如环氧基化合物的碱反应性化合物中，还具有高的性能 耐碱性和低亲核性，并且产生强碱，包含碱产生剂和碱反应性化合物的碱反应性组合物，以及产生碱的方法等。本发明涉及由 通式（A），包含该化合物的碱发生剂，包含碱发生剂和碱反应性化合物的碱反应性组合物，以及产生碱的方法等（其中R 1至R 5各自独立地表示 氢原子;烷基;可具有取代基的芳基;或可具有取代基的芳烷基，R6表示氢原子;可具有取代基的烷基;可具有取代基的烷基 甲基 炔基; 可以具有取代基的芳基; 或可具有取代基的芳基烷基，R7表示氢原子; 可以具有氨基的烷基; 可以具有取代基的芳基; 或可以具有取代基的芳烷基，Z-表示衍生自具有特定结构的羧酸的阴离子。）

    Compositions and methods for the treatment of moderate to severe pain
    7.
    发明授权
    Compositions and methods for the treatment of moderate to severe pain 有权
    用于治疗中度至重度疼痛的组合物和方法

    公开(公告)号：US09321775B2

    公开(公告)日：2016-04-26

    申请号：US14399183

    申请日：2013-02-04

    Applicant: Mahesh Kandula

    Inventor： Mahesh Kandula

    IPC: C07D487/04 ,  C07D333/24 ,  C07C59/84 ,  C07C69/738 ,  C07C59/76 ,  C07C51/56 ,  A61K31/215 ,  A61K31/385 ,  A61K31/407 ,  A61K31/192 ,  A61K31/194 ,  A61K31/198 ,  A61K31/202 ,  A61K31/235

    CPC classification number: C07D487/04 ,  A61K31/192 ,  A61K31/194 ,  A61K31/198 ,  A61K31/202 ,  A61K31/215 ,  A61K31/235 ,  A61K31/385 ,  A61K31/407 ,  C07C51/56 ,  C07C59/76 ,  C07C59/84 ,  C07C69/738 ,  C07D333/24

    Abstract: The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II, and methods for treating or preventing or modulating moderate to severe pain in a disease may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of pain, severe pain, chronic pain, chemotherapy induced pain, epilepsy, glaucoma, arthritis, tooth aches, inflammation, musculoskeletal pain, sciatica, radiculopathy pain, migraine, neuropathic pain, post herpetic neuralgia, neuralgia pain, multiple sclerosis, multiple sclerosis, restless legs syndrome (RLS), cluster headache, depression, fibromyalgia, amyotrophic lateral sclerosis (ALS), convulsions, partial seizures, mood-stabilizing agent and bipolar disorder.

    Abstract translation: 本发明涉及式I和式II化合物或其药学上可接受的盐，以及多晶型物，溶剂合物，对映体，立体异构体和水合物。 包含有效量的式I或式II化合物的药物组合物，以及用于治疗或预防或调节疾病中至重度疼痛的方法可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外 给药，糖浆或注射。 此类组合物可用于治疗疼痛，剧烈疼痛，慢性疼痛，化学疗法诱导的疼痛，癫痫，青光眼，关节炎，牙齿酸痛，炎症，肌肉骨骼疼痛，坐骨神经痛，神经根痛，偏头痛，神经性疼痛，疱疹后神经痛，神经痛 ，多发性硬化症，多发性硬化症，不宁腿综合征（RLS），丛集性头痛，抑郁症，纤维肌痛，肌萎缩性侧索硬化（ALS），抽搐，部分发作，情绪稳定剂和双相障碍。

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