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    Synthesis of racemic 3-fluoro-alanine and its salts
    2.
    发明授权
    Synthesis of racemic 3-fluoro-alanine and its salts 失效
    外消旋3-氟 - 丙氨酸及其盐的合成

    公开(公告)号：US4149012A

    公开(公告)日：1979-04-10

    申请号：US840335

    申请日：1977-10-07

    Applicant: Ulf-H. Dolling ,  Edward J. J. Grabowski ,  Erwin F. Schoenewaldt ,  Meyer Sletzinger

    Inventor： Ulf-H. Dolling ,  Edward J. J. Grabowski ,  Erwin F. Schoenewaldt ,  Meyer Sletzinger

    IPC: C07C59/21 ,  C07C227/08 ,  C07C99/00

    CPC classification number: C07C227/08 ,  C07C59/21

    Abstract: The racemate of 3-fluoro-alanine, and salts thereof, are prepared by reductive amination of 3-fluoro-pyruvic acid, its hydrate, or salts thereof, via the intermediate 2-imino-3-fluoro propionic acid salt, using alkali metal borohydrides as reducing agents. The racemates thus obtained are valuable in the production of 3-fluoro-D-alanine and its pharmacologically acceptable salts, and derivatives thereof, which are potent antibacterial agents.

    Abstract translation: 3-氟 - 丙氨酸的外消旋物及其盐通过使用碱金属通过中间体2-亚氨基-3-氟丙酸盐还原胺化3-氟 - 丙酮酸，其水合物或其盐来制备 硼氢化物作为还原剂。 由此获得的外消旋物在制备作为强效抗菌剂的3-氟-D-丙氨酸及其药理学上可接受的盐及其衍生物中是有价值的。

    Perfluorinated linear polyethers having reactive terminal groups at both ends of the chain and process for the preparation thereof
    4.
    发明授权
    Perfluorinated linear polyethers having reactive terminal groups at both ends of the chain and process for the preparation thereof 失效
    具有链的两端的反应性终端组的全氟化线性聚合物及其制备方法

    公开(公告)号：US3847978A

    公开(公告)日：1974-11-12

    申请号：US83448669

    申请日：1969-06-18

    Applicant: MONTEDISON SPA

    Inventor： SIANESI D ,  CAPORICCIO G ,  MENSI D

    IPC: C07C51/60 ,  C07C59/21 ,  C07C59/315 ,  C08G65/00 ,  C08G65/329 ,  C08G69/42 ,  C07C59/22

    CPC classification number: C08G69/42 ,  C07C51/60 ,  C07C59/21 ,  C07C59/315 ,  C08G65/007 ,  C08G65/329

    Abstract: AT LEAST ONE OF THE LATTER TWO TERMINAL GROUPS BEING PRESENT WHEN-C6F6O- REPEATING UNITS ARE PRESENT, WITH THE FURTHER PROVISO THAT WHEN SAID -CF2CO-CF3 TERMINAL GROUP IS PRESENT, ONE SAID OTHER TWO TERMINAL GROUPS IS ALSO PRESENT, AND THE CORRESPONDING ACYL HALIDES, LOWER ALKYL ESTERS AND METAL SATLS.

    -CF2-COOH, -C(-CF3)-COOH, -CF2-CO-CF3

    TERMINAL GROUP BONDED TO SAID CHAIN THROUGH AN ETHER OXYGEN, SAID POLYETHER HAVING TERMINAL GROUPS BONDED TO SAID CHAIN THROUGH AN ETHER OXYGEN, SAID TERMINAL GROUPS BEING SELECTED FROM THE GROUP CONSISTING OF

    -CF2-CO-CF3

    1. BIFUNCTIONAL PERFLUORINATED POLYETHERS AND MIXTURES THEREOF, HAVING CHEMICALLY REACTIVE TERMINAL GROUPS AT BOTH ENDS OF THE CHAIN, SAID POLYETHER HAVING 1 FROM 1 TO 100 REPEAING UNITS SELECTED FROM THE GROUP CONSISTING OF -C3F6O-, -C2F4O-, AND -CF2O-, WHREIN C2F6 AND C2F4 ARE PERFLUOROALKYLENE UNITS DERIVED FROM THE OPENING OF THE DOUBLE BOND OF A HEXAFLUOROPROPYLENE AND OF A TETRAFLUOROETHYLENE MOLECULE, RESPECTIVELY, THE DIFFERENT OXYPERFLUOROALKYLENE UNITS HAVING A RANDOM DISTRIBUTION ALONG THE CHAIN, THERE BEING NO MORE THAN 50 OFF ANY ONE OF SAID SPECIES OF REPATING UNITS, SAID -CF2OREPEATING UNITS BEING PRESENT ONLY WHEN EITHER OR BOTH OF SAID -C2FF4O- AND C3F6O- REPEATING UNITS ARE PRESENT, SAID -C2F4O -UNITS BEING PRESENT ONLY WHEN SAID -CF2O- UNITS ARE ALSO PRESENT, SAID C3F6O- UNITS BEING PRESENT ONLY WHEN EITHER SAID -CF2O- UNITS ARE ALSO PRESENT OR WHEN SAID POLYETHER CONTAINS A

    Fluorosulfonate containing polyfluorocarbonyl compounds
    7.
    发明授权
    Fluorosulfonate containing polyfluorocarbonyl compounds 失效
    含氟磺酸盐的多氟羰基化合物

    公开(公告)号：US4603017A

    公开(公告)日：1986-07-29

    申请号：US720163

    申请日：1985-04-05

    Applicant: Hans Millauer ,  Gunter Siegemund ,  Werner Schwertfeger

    Inventor： Hans Millauer ,  Gunter Siegemund ,  Werner Schwertfeger

    IPC: C07C69/708 ,  C07C45/54 ,  C07C49/167 ,  C07C51/00 ,  C07C51/373 ,  C07C53/50 ,  C07C59/21 ,  C07C59/347 ,  C07C59/58 ,  C07C59/88 ,  C07C67/00 ,  C07C67/313 ,  C07C69/716 ,  C07C301/00 ,  C07C303/00 ,  C07C305/00 ,  C07C305/26 ,  C25B3/00 ,  C25B3/02 ,  C07C141/00

    CPC classification number: C07C45/54 ,  C07C305/26 ,  C07C49/167 ,  C07C51/00 ,  C07C59/21

    Abstract: Perfluorocarbonyl compounds of the formulae IV and V ##STR1## in which R.sub.f denotes perfluoroalkyl, R'.sub.f denotes perfluoroalkylene, R denotes F, Cl, perfluoroalkyl or --OR"' (R"'=alkyl, aryl or aralkyl) and n denotes a number from 0 to 10, are prepared, starting from compounds of the formula I ##STR2## in which R.sub.f, R'.sub.f and n have the same meaning as in the formulae IV and V and R" is F, Cl or perfluoroalkyl, by electrolysis in an electrolyte consisting of fluorosulfonic acid/alkali metal fluorosulfonate and, if necessary, esterification with R"'OH, and decomposition ##STR3## in the presence of catalytic amounts of alkali metal fluorides and/or aprotic N-bases. Most of the compounds IV and V are new; the latter are, above all, valuable heat transfer fluids, lubricating oils or intermediates for the preparation of other F-organic compounds.

    Abstract translation: （IV）的全氟羰基化合物其中Rf表示全氟烷基，R'f表示全氟亚烷基，R表示F，Cl，全氟烷基或-OR“（R”'） =烷基，芳基或芳烷基），n表示0至10的数，从其中R f，R'f和n与式（I）中相同含义的式I的化合物 IV和V和R“是F，Cl或全氟烷基，通过在由氟磺酸/碱金属氟代磺酸盐组成的电解质中电解并在需要时与R”OH进行酯化，并在催化剂存在下分解“IMAGE” 碱金属氟化物和/或非质子N-碱的量。 大多数化合物IV和V是新的; 后者首先是有价值的传热流体，润滑油或用于制备其它F-有机化合物的中间体。

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