公开(公告)号：US09732056B2

公开(公告)日：2017-08-15

申请号：US14854705

申请日：2015-09-15

Applicant: Givaudan, S.A.

Inventor： Fridtjof Schröder ,  Urs Mueller ,  Jurg Daniel Oetiker

IPC: C07C403/20 ,  C07C69/608 ,  C07C51/38 ,  C07C57/26 ,  C07C67/475 ,  C07C67/32 ,  C07D307/92

CPC classification number: C07D307/92 ,  C07C51/38 ,  C07C57/26 ,  C07C67/32 ,  C07C67/475 ,  C07C69/608 ,  C07C403/20 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/48

Abstract: Compounds of the formula 1 wherein, R is hydrogen, alkyl or substituted alkyl, aryl or substituted aryl, are useful intermediates in the synthesis of fragrance ingredients such as Ambrox 2

公开(公告)号：US20170112792A1

公开(公告)日：2017-04-27

申请号：US15126714

申请日：2015-03-19

Applicant: Beth Israel Deaconess Medical Center, Inc.

Inventor： Kun Ping LU ,  Xiao Zhen ZHOU ,  Shuo WEI

IPC: A61K31/203 ,  A61K45/06 ,  C12Q1/533 ,  C07C57/26

CPC classification number: A61K31/203 ,  A61K38/21 ,  A61K45/06 ,  C07C57/26 ,  C12Q1/533 ,  G01N2333/99 ,  G01N2500/04 ,  G01N2800/24 ,  G01N2800/307 ,  G01N2800/7028 ,  G16B35/00 ,  G16C20/60 ,  Y02A50/414 ,  A61K2300/00

Abstract: The invention features all-trans retinoic acid (ATRA)-related compounds capable of associating with Pin1 and methods of identifying the same. The invention also provides methods of treating a condition selected from the group consisting of a proliferative disorder, an autoimmune disease, and an addiction condition characterized by elevated Pin1 marker levels, Pin1 degradation, and/or reduced Pin1 Ser71 phosphorylation in a subject by administering a retinoic acid compound. Additionally, the invention features methods of treating proliferative disorders, autoimmune diseases, and addiction conditions (e.g., diseases, disorders, and conditions characterized by elevated Pin1 marker levels) by administering a retinoic acid compound in combination with another therapeutic compound. The invention also features a co-crystal including Pin1 and a retinoic acid compound. Finally, the invention also provides methods of developing and identifying enhanced Pin1-targeted ATRA-related compounds based on the newly defined unique binding pockets in the Pin1 active site revealed from the co-crystal structure, structure-activity relationship, and structural modeling.

公开(公告)号：US20160096817A1

公开(公告)日：2016-04-07

申请号：US14846016

申请日：2015-09-04

Applicant: Allergan, Inc.

Inventor： Yariv Donde ,  Jeremiah H. Nguyen ,  Karen M. Kedzie ,  Daniel W. Gil ,  John E. Donello ,  Wha-Bin Im

IPC: C07D333/56 ,  C07C57/26 ,  C07C57/48 ,  C07C69/738

CPC classification number: C07D333/56 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/559 ,  C07C57/26 ,  C07C57/48 ,  C07C59/90 ,  C07C69/732 ,  C07C69/738 ,  C07D333/62 ,  C07D409/08

Abstract: Disclosed herein is a method comprising administering a compound to a mammal suffering from an inflammatory bowel disease for the treatment of said disease, said compound having a structure according to Formula I wherein X, Y, B, R2, R3, R4, R5, R6 and n have the meanings found herein.

公开(公告)号：US09163000B2

公开(公告)日：2015-10-20

申请号：US14563312

申请日：2014-12-08

Applicant: Givaudan, S.A.

Inventor： Fridtjof Schröder ,  Urs Mueller ,  Jürg Daniel Oetiker

IPC: C07D307/92 ,  C07C403/20 ,  C07C57/26 ,  C07C67/475

CPC classification number: C07D307/92 ,  C07C51/38 ,  C07C57/26 ,  C07C67/32 ,  C07C67/475 ,  C07C69/608 ,  C07C403/20 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/48

Abstract: Compounds of the formula 1 wherein, R is hydrogen, alkyl or substituted alkyl, aryl or substituted aryl, are useful intermediates in the synthesis of fragrance ingredients such as Ambrox 2

Abstract translation: 式1的化合物，其中R是氢，烷基或取代的烷基，芳基或取代的芳基，是芳香成分合成中的有用中间体，例如Ambrox 2

公开(公告)号：US09086624B2

公开(公告)日：2015-07-21

申请号：US13957175

申请日：2013-08-01

Applicant: SHIN-ETSU CHEMICAL CO., LTD.

Inventor： Masayoshi Sagehashi ,  Jun Hatakeyama ,  Koji Hasegawa

IPC: G03F7/004 ,  G03F7/38 ,  C07C69/54 ,  C07C69/74 ,  C07C69/75 ,  C07C69/78 ,  C08F220/10 ,  C08F220/14 ,  C08F220/16 ,  C08F220/24 ,  C08F222/10 ,  C08F222/14 ,  C08F228/02 ,  G03F7/038 ,  C07C57/26 ,  G03F7/20 ,  G03F7/039

CPC classification number: G03F7/0382 ,  C07C57/26 ,  C07C69/54 ,  C07C69/74 ,  C07C69/75 ,  C07C69/78 ,  C08F220/10 ,  C08F220/14 ,  C08F220/16 ,  C08F220/24 ,  C08F222/10 ,  C08F222/14 ,  C08F228/02 ,  G03F7/0045 ,  G03F7/0046 ,  G03F7/038 ,  G03F7/0397 ,  G03F7/20 ,  G03F7/2041 ,  G03F7/325 ,  G03F7/38

Abstract: A polymer comprising recurring units derived from a (meth)acrylate monomer of tertiary ester type having branched alkyl on alicycle is used to form a resist composition. When subjected to exposure, PEB and organic solvent development, the resist composition is improved in dissolution contrast.

Abstract translation: 使用包含衍生自在脂环上具有支链烷基的叔酯型（甲基）丙烯酸酯单体的重复单元的聚合物以形成抗蚀剂组合物。 当曝光，PEB和有机溶剂显影时，抗蚀剂组合物的溶解对比度提高。

公开(公告)号：US20150175519A1

公开(公告)日：2015-06-25

申请号：US14403763

申请日：2013-05-28

Applicant: NUtech Ventures

Inventor： Wantanee Sittiwong ,  Patrick H. Dussault ,  Raul Barletta ,  Robert Powers

IPC: C07C59/21 ,  C07C53/134 ,  C07C59/205 ,  C07C59/11 ,  C08F216/16 ,  C07C51/09 ,  C08F132/04 ,  C08F232/04 ,  C08F212/08 ,  C07C57/26 ,  C07C67/313

CPC classification number: C07C59/21 ,  C07C51/09 ,  C07C53/134 ,  C07C57/26 ,  C07C59/11 ,  C07C59/205 ,  C07C67/313 ,  C07C2601/04 ,  C08F132/04 ,  C08F212/08 ,  C08F216/165 ,  C08F232/04

Abstract: This disclosure relates to amphiphilic compounds containing a cyclobutene or cyclobutane moiety. In some embodiments, the compounds are useful for treating infection by Mycobacterium such as Mycobacterium tuberculosis. Cyclobutene containing compounds are also useful as monomers in the preparation of amphiphilic polymers.

Abstract translation: 本公开涉及含有环丁烯或环丁烷部分的两亲化合物。 在一些实施方案中，所述化合物可用于治疗结核分枝杆菌（Mycobacterium tuberculosis）等分枝杆菌感染。 含有环烯的化合物也可用作制备两亲性聚合物的单体。

公开(公告)号：US20150045574A1

公开(公告)日：2015-02-12

申请号：US14335229

申请日：2014-07-18

Applicant: Johann Mulzer ,  Jurgen Ramharter ,  Steffen Hering ,  Sophia Khom

Inventor： Johann Mulzer ,  Jurgen Ramharter ,  Steffen Hering ,  Sophia Khom

IPC: C07C69/608 ,  C07C57/26 ,  C07D307/93 ,  C07C69/732 ,  C07C29/42

CPC classification number: C07C69/608 ,  A61K31/16 ,  C07C29/42 ,  C07C57/26 ,  C07C69/732 ,  C07C231/02 ,  C07C233/02 ,  C07C233/10 ,  C07C233/16 ,  C07C243/32 ,  C07C2602/24 ,  C07D307/93

Abstract: The present invention is directed to compounds, intermediates and methods for making valerenic acid and its derivatives as well as the use of such compounds as GABAA receptor ligands.

Abstract translation: 本发明涉及制备戊酰酸及其衍生物的化合物，中间体和方法以及这些化合物如GABA A受体配体的用途。

公开(公告)号：US20140045123A1

公开(公告)日：2014-02-13

申请号：US13957175

申请日：2013-08-01

Applicant: SHIN-ETSU CHEMICAL CO., LTD.

Inventor： Masayoshi Sagehashi ,  Jun Hatakeyama ,  Koji Hasegawa

IPC: G03F7/038 ,  G03F7/20 ,  C07C57/26

CPC classification number: G03F7/0382 ,  C07C57/26 ,  C07C69/54 ,  C07C69/74 ,  C07C69/75 ,  C07C69/78 ,  C08F220/10 ,  C08F220/14 ,  C08F220/16 ,  C08F220/24 ,  C08F222/10 ,  C08F222/14 ,  C08F228/02 ,  G03F7/0045 ,  G03F7/0046 ,  G03F7/038 ,  G03F7/0397 ,  G03F7/20 ,  G03F7/2041 ,  G03F7/325 ,  G03F7/38

Abstract: A polymer comprising recurring units derived from a (meth)acrylate monomer of tertiary ester type having branched alkyl on alicycle is used to form a resist composition. When subjected to exposure, PEB and organic solvent development, the resist composition is improved in dissolution contrast.

Abstract translation: 使用包含衍生自在脂环上具有支链烷基的叔酯型（甲基）丙烯酸酯单体的重复单元的聚合物以形成抗蚀剂组合物。 当曝光，PEB和有机溶剂显影时，抗蚀剂组合物的溶解对比度提高。

公开(公告)号：US5955084A

公开(公告)日：1999-09-21

申请号：US944865

申请日：1997-10-06

Applicant: Dharam Chand Jain ,  Sudeep Tandon ,  Rajendra Singh Bhakuni ,  Mohammed Shafique Siddique ,  Atul Prakash Kahol ,  Ram Prakash Sharma ,  Sushil Kumar ,  Asish Kumar Bhattacharya

Inventor： Dharam Chand Jain ,  Sudeep Tandon ,  Rajendra Singh Bhakuni ,  Mohammed Shafique Siddique ,  Atul Prakash Kahol ,  Ram Prakash Sharma ,  Sushil Kumar ,  Asish Kumar Bhattacharya

IPC: A61K36/00 ,  A61K36/282 ,  C07C51/48 ,  C07C57/26 ,  C07D493/18 ,  C07D493/20 ,  C11B5/00 ,  C11B9/02 ,  C11B13/00 ,  A61K35/78

CPC classification number: A61K36/282

Abstract: This invention relates to a novel process for the dual production of essential oil and artemisinin from the plant Artemisia annua, said process comprising extracting the plant with hexane, partitioning the hexane extract between hexane and acetonitrile, hydrodistillation of hexane residue and Marc to yield essential oil, further fractionation of acetonitrile solvent between hexane-benzene mixture to remove artemisinic acid, chromatographing of the acetonitrile phase to produce substantially pure artemisinin, the artemisinic acid is reduced to obtain dihydro artemisinic acid which is then oxidised in a single step to form artemisinin.

Abstract translation: 本发明涉及一种用于从植物青蒿双重生产精油和青蒿素的新方法，所述方法包括用己烷萃取植物，在己烷和乙腈之间分配己烷提取物，将己烷残渣和马克加热蒸馏得到精油 乙腈溶剂进一步分离己烷 - 苯混合物以去除青蒿酸，色谱分离乙腈相以产生基本上纯的青蒿素，将青蒿酸还原得到二氢青蒿酸，然后在一步中氧化形成青蒿素。

公开(公告)号：US5698514A

公开(公告)日：1997-12-16

申请号：US450823

申请日：1995-05-25

Applicant: Wilhelmus Johannes Wiegers ,  Marie R. Hanna

Inventor： Wilhelmus Johannes Wiegers ,  Marie R. Hanna

IPC: C07C51/353 ,  C07C51/38 ,  C07C57/26 ,  C07C69/608 ,  C11B9/00 ,  A61K7/46

CPC classification number: C11B9/0053 ,  C07C51/353 ,  C07C51/38 ,  C07C57/26 ,  C07C69/608 ,  C11B9/0049

Abstract: Described are allyl esters of 2-norbornane acrylic acids and 2-norbornylidene propionic acids defined according to the generic structure: ##STR1## wherein the wavy line represents a carbon-carbon single bond or a carbon-carbon double bond; wherein one of the dashed lines is carbon-carbon single bond and the other of the dashed lines is a carbon-carbon double bond; and wherein R represents methyl or hydrogen; as well as methods for augmenting or enhancing the aroma of consumable materials including perfumes, colognes and perfumed articles.

Abstract translation: 描述了根据通用结构定义的2-降冰片烷基丙烯酸和2-降冰片烯基丙酸的烯丙酯：其中波浪线代表碳 - 碳单键或碳 - 碳双键; 其中虚线中的一条是碳 - 碳单键，另一条虚线是碳 - 碳双键; 并且其中R表示甲基或氢; 以及用于增强或增强包括香水，古龙水和香料制品在内的消耗材料的香气的方法。