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    BIOCHEMICAL SELECTIVITY PROFILING AGAINST RNA HELICASES
    3.
    发明公开
    BIOCHEMICAL SELECTIVITY PROFILING AGAINST RNA HELICASES 审中-公开

    公开(公告)号：US20240167074A1

    公开(公告)日：2024-05-23

    申请号：US18549554

    申请日：2022-03-08

    Applicant: Baylor College of Medicine

    Inventor： Thomas F. Westbrook ,  Kristen Karlin ,  Calla Olson

    IPC: C12Q1/34 ,  G01N33/50

    CPC classification number: C12Q1/34 ,  G01N33/5008 ,  G01N2500/04 ,  G01N2500/10

    Abstract: Embodiments of the disclosure concern identification of suitable inhibitors of components of RNA metabolism, including those involved with splicing, such as RNA helicases. The disclosure includes in vitro screens for small molecule inhibitors that are selective for a group of RNA helicases but that are counter-selective for another group of RNA helicases. In specific embodiments, the disclosure includes a system for inhibitor analysis that includes assay development and optimization that leads to feasible screening of the intended target(s) and continued counter-selection against undesirable targets throughout the process.

    METHODS OF SCREENING COMPOUNDS
    8.
    发明公开
    METHODS OF SCREENING COMPOUNDS 审中-公开

    公开(公告)号：US20230375542A1

    公开(公告)日：2023-11-23

    申请号：US18339347

    申请日：2023-06-22

    Applicant: Depixus SAS

    Inventor： Gordon HAMILTON ,  Jimmy OUELLET ,  Zhen WANG ,  Henning LABUHN

    IPC: G01N33/543 ,  G01N33/53

    CPC classification number: G01N33/54373 ,  G01N33/5308 ,  G01N33/54326 ,  G01N2500/04

    Abstract: Disclosed herein are methods of screening candidate binding compounds to a plurality of target nucleic acids either of the same sequence or of different sequences utilizing a device configured to detect changes in the folding and unfolding force of the target nucleic acid upon binding to various candidate binding compounds. In the presence of a plurality of nucleic acid sequences, the methods described herein also can rapidly determine the specificity of the small molecule or polypeptide to a nucleic acid structure. Also, disclosed herein are methods of measuring binding kinetics of binding compounds to a target nucleic acid using a device configured to detect changes in the folding and unfolding force of the target nucleic acid upon binding to varying concentrations of the candidate binding compound.

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